Toxicological profiles - Bromoform and chlorodibromomethane

TOXICOLOGICAL PROFILE FOR BROMOFORM AND CHLORODIBROMOMETHANE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 9
LIST OF TABLES......Page 11
1.1 WHAT ARE CHLORODIBROMOMETHANE AND BROMOFORM?......Page 12
1.2 HOW MIGHT I BE EXPOSED TO CHLORODIBROMOMETHANE OR BROMOFORM?......Page 13
1.5 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 14
1.6 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO CHLORODIBROMOMETHANE OR BROMOFORM?......Page 19
1.8 WHERE CAN I GET MORE INFORMATION?......Page 20
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 22
2.2.1.2 Systemic Effects......Page 23
2.2.1.8 Cancer......Page 24
2.2.2.1 Death......Page 25
2.2.2.2 Systemic Effects......Page 39
2.2.2.3 Immunological Effects......Page 41
2.2.2.4 Neurological Effects......Page 42
2.2.2.6 Reproductive Effects......Page 43
2.2.2.8 Cancer......Page 44
2.3.1.1 Inhalation Exposure......Page 46
2.3.2.2 Oral Exposure......Page 47
2.3.3 Metabolism......Page 48
2.3.4.1 Inhalation Exposure......Page 50
2.4 RELEVANCE TO PUBLIC HEALTH......Page 52
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 58
2.5.1 Biomarkers Used to Identify or Quantify Exposure to Chlorodibromomethane and Bromoform......Page 59
2.6 INTERACTIONS WITH OTHER CHEMICALS......Page 60
2.8 ADEQUACY OF THE DATABASE......Page 61
2.8.2 Identification of Data Needs......Page 62
2.8.3 On-going Studies......Page 69
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 72
4.3 USE......Page 76
4.4 DISPOSAL......Page 77
5.2.2 Water......Page 78
5.3.1 Transport and Partitioning......Page 81
5.3.2.l Air......Page 82
5.4.1 Air......Page 83
5.4.2 Water......Page 84
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 86
5.7.1 Identification of Data Needs......Page 88
5.7.2 On-going Studies......Page 91
6.1 BIOLOGICAL MATERIALS......Page 92
6.3 ADEQUACY OF THE DATA BASE......Page 93
6.3.1 Identification of Data Needs......Page 96
6.3.2 On-going Studies......Page 97
7. REGULATIONS AND ADVISORIES......Page 98
8. REFERENCES......Page 102
Embryotoxicity and Fetotoxicity......Page 127
Lowest-Observed-Adverse-Effect Level......Page 128
Reference Dose......Page 129
Uncertainty Factor......Page 130
PEER REVIEW......Page 131