Toxicological profiles - Bromodichloromethane

TOXICOLOGICAL PROFILE FOR BROMODICHLOROMETHANE......Page 1
DISCLAIMER......Page 2
FOREWORD......Page 3
CONTENTS......Page 5
LIST OF FIGURES......Page 9
LIST OF TABLES......Page 11
1.2 HOW MIGHT I BE EXPOSED TO BROMODICHLOROMETHANE?......Page 13
1.5 IS THERE A MEDICAL TEST TO DETERMINE IF I HAVE BEEN EXPOSED TO BROMODICHLOROMETHANE?......Page 14
1.8 WHERE CAN I GET MORE INFORMATION?......Page 15
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 21
2.2.1.8 Cancer......Page 22
2.2.2.2 Systemic Effects......Page 23
2.2.2.3 Immunological Effects......Page 31
2.2.2.5 Developmental Effects......Page 32
2.2.3 Dermal Exposure......Page 33
2.3 RELEVANCE TO PUBLIC HEALTH......Page 34
2.4 LEVELS IN HUMAN TISSUES AND FLUIDS ASSOCIATED WITH HEALTH EFFECTS......Page 35
2.6.1.2 Oral Exposure......Page 37
2.6.3 Metabolism......Page 38
2.7 INTERACTIONS WITH OTHER CHEMICALS......Page 39
2.9 ADEQUACY OF THE DATABASE......Page 40
2.9.2 Data Needs......Page 41
2.9.3 Ongoing Studies......Page 45
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 47
4.4 DISPOSAL......Page 51
4.5.1 Data Needs......Page 52
5.2.2 Water......Page 53
5.3.1 Transport and Partitioning......Page 54
5.3.2.2 Water......Page 55
5.4.2 Water......Page 56
5.4.3 Soil......Page 57
5.6 POPULATIONS WITH POTENTIALLY HIGH EXPOSURES......Page 58
5.7.1 Data Needs......Page 59
5.7.2 Ongoing Studies......Page 61
6.1 BIOLOGICAL MATERIALS......Page 63
6.3.1 Data Needs......Page 65
6.3.2 Ongoing Studies......Page 67
7. REGULATIONS AND ADVISORIES......Page 69
8. REFERENCES......Page 71
Developmental Toxicity......Page 83
Lethal Dose (LDLO)......Page 84
Permissible Exposure Limit (PEL)......Page 85
TD50 (toxic dose)......Page 86
Uncertainty Factor (UF)......Page 87
APPENDIX: PEER REVIEW......Page 89