Prostaglandins, Leukotrienes, and Lipoxins: Biochemistry, Mechanism of Action, and Clinical Applications

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Lipoxins....Pages 3-16
Occurrence of Leukotrienes in Rat Brain....Pages 17-26
Properties of Prostaglandin-Biosynthesizing Enzymes....Pages 27-33
A Two-Receptor Model for the Mechanism of Action of Prostaglandins in the Renal Collecting Tubule....Pages 35-45
Prostaglandin Endoperoxide Synthase from Human Cell Line Lu-65....Pages 47-55
Coronary Arterial Prostacyclin Synthetase and Prostaglandin E 2 Isomerase Activities....Pages 57-67
Glutathione Transferases Catalyzing Leukotriene C Synthesis and Metabolism of Leukotrienes C 4 and E 4 in Vivo and in Vitro ....Pages 69-77
Formation and Role of Lipoxygenase Products in Human Platelets....Pages 79-85
Lipoxygenation of Mitochondrial Membranes by Reticulocyte Lipoxygenase....Pages 87-95
The Major Pathway for Leukotriene B 4 Catabolism in Human Polymorphonuclear Leukocytes Involves ω-Oxidation by a Cytochrome P-450 Enzyme....Pages 97-109
Hematin-Assisted Intramolecular Oxygen Transfer Mechanism Is Involved in the Formation of 8-Hydroxy-11,12-epoxyeicosa-5,9,14-trienoic Acid (8H-11, 12-EPETE) from 12-HPETE....Pages 111-116
Front Matter....Pages 117-117
Molecular Mechanisms of the Modulation of Phospholipid Metabolism by Glucocorticoids....Pages 119-123
Transmembrane Signal in the Secretory Process of A23187-Stimulated Human Leukocytes....Pages 125-132
Postphospholipase Activation of Lipoxygenase/Leukotriene Systems....Pages 133-146
Regulation of Cyclooxygenase Synthesis in Vascular Smooth Muscle Cells by Epidermal Growth Factor....Pages 147-156
Fuel Metabolism as a Determinant of Arachidonic Acid Release and Oxygenation....Pages 157-167
Regulation of Differentiation of Canine Kidney (MDCK) Cells by Prostaglandins....Pages 169-183
Human Trabecular Meshwork Cells....Pages 185-192
Prostacyclin Can Inhibit DNA Synthesis in Vascular Smooth Muscle Cells....Pages 193-204
Quantitation of Arachidonate Released during the Platelet Phosphatidylinositol Response to Thrombin....Pages 205-211
Front Matter....Pages 117-117
Phospholipases in the Macrophage....Pages 213-220
Lipid Bodies....Pages 221-239
Differences between the Effects of f-Met-Leu-Phe and Leukotriene B 4 on Phosphoinositide Turnover and Their Relationship to Calcium Mobilization and Protein Kinase C Activation....Pages 241-250
Prostaglandylinositol Cyclic Phosphate....Pages 251-257
Front Matter....Pages 259-259
Regulatory Mechanisms in Prostacyclin-Blood Vessel Interactions....Pages 261-266
A Comparison of the Contractile Responses of Rodent and Human Pulmonary Vascular Segments to Eicosanoids....Pages 267-273
Leukotriene C 4 Is Released from the Anaphylactic Heart: A Case for Its Direct Negative Inotropic Effect....Pages 275-288
Comparative Responses to Leukotriene D 4 in the Sheep and Cat....Pages 289-299
Platelet-Activating Factor as a Modulator of Cardiac and Coronary Functions....Pages 301-310
Distinct Sulfidopeptide Leukotriene Receptors....Pages 311-320
Some Novel Aspects of the Function of Prostaglandin E 2 in the Coronary Circulation....Pages 321-332
Prostaglandin H 2 Causes Calcium Mobilization in Intact Human Platelets....Pages 333-344
Control of Ca 2+ Mobilization and Polyphosphoinositide Metabolism in Platelets by Prostacyclin....Pages 345-356
Heme—Polyenoic Acid Interaction and Prostaglandin Synthesis....Pages 357-369
Cardiac Effects of Peptidoleukotrienes....Pages 371-378
Effects of Selenium Deficiency on Arachidonic Acid Metabolism and Aggregation in Rat Platelets....Pages 379-385
Different Functions of Phosphoinositide Turnover and Arachidonate Metabolism for Platelet Activation....Pages 387-392
Comparative Absorption and Lymphatic Transport of (ω-3) Eicosapentaenoic Acid, (ω-6) Arachidonic Acid, and (ω-9) Oleic Acid....Pages 393-403
Front Matter....Pages 405-405
Status of Clinical Trials Evaluating Eicosanoids in Atherosclerotic Vascular Disease and Thrombosis....Pages 407-416
Eicosanoids and Allograft Rejection....Pages 417-422
Front Matter....Pages 405-405
Prostaglandins in Human Seminal Fluid and Its Relation to Fertility....Pages 423-431
Arachidonate Lipoxygenase Products and Psoriasis....Pages 433-441
Coronary Leukotriene Levels and Myocardial Ischemia....Pages 443-455
Decreased Concentrations of Prostaglandin F 2α in Delayed Labor....Pages 457-464
The Differentiated Contractile Effects of Prostaglandins on the Various Segments of the Pregnant Human Uterus....Pages 465-472
Front Matter....Pages 473-473
Membrane Events and Guanylate Cyclase Activation in Mitogen-Stimulated Lymphocytes....Pages 475-486
Biochemical Cascade Involved in Mast Cell Activation for Mediator Release....Pages 487-499
Stimulation of Lymphocyte Guanylate Cyclase by Arachidonic Acid and HETEs....Pages 501-509
Release of Leukotrienes B 4 and D 4 by the Anaphylactic Guinea Pig Lung in Vitro ....Pages 511-517
Mechanisms Involved in the Mediation of Contractions of Airway Smooth Muscle to Arachidonate Metabolites and Other Spasmogens....Pages 519-530
Macrophage Fcγ2b Receptor Expression and Receptor-Mediated Phospholipase Activity....Pages 531-546
Differential Effects of Leukotriene B 4 and Its Analogues on Suppressor and Helper Cell Function....Pages 547-553
Eicosanoid Precursor Fatty Acids in Plasma Phospholipids and Arachidonate Metabolism in Polymorphonuclear Leukocytes in Asthma....Pages 555-563
Induction of Suppressor T Cells in Vitro by Arachidonic Acid Metabolites Issued from the Lipoxygenase Pathway....Pages 565-575
Front Matter....Pages 577-577
Novel Aspects of Aspirin Action....Pages 579-582
Cyclooxygenase Inhibitors....Pages 583-591
Comparative Biochemistry of Lipoxygenase Inhibitors....Pages 593-607
Inhibitors of Arachidonic Acid Metabolism Inhibit Tumor-Promoter-Stimulated Chemiluminescence in Murine Keratinocytes....Pages 609-618
Cyclooxygenase Inhibitors....Pages 619-625
Arylmethyl Phenyl Ethers....Pages 627-637
Front Matter....Pages 577-577
Relationship between Drug Absorption, Inhibition of Cyclooxygenase and Lipoxygenase Pathways, and Development of Gastric Mucosal Damage by Nonsteroidal Antiinflammatory Drugs in Rats and Pigs....Pages 639-653
Biosynthesis of Leukotriene B 4 in Human Leukocytes....Pages 655-668
Novel Synthesis of Potent Site-Specific Phospholipase A 2 Inhibitors....Pages 669-676
Back Matter....Pages 677-705