Cell Calcium Metabolism: Physiology, Biochemistry, Pharmacology, and Clinical Implications

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Hormonal Inhibition of the Liver Plasma Membrane (Ca 2+ —Mg 2+ ) ATPase is Mediated by a G s -like Protein....Pages 3-11
The High-Affinity (Ca 2+ —Mg 2+ )ATPase of Rat Liver Plasma Membrane Hydrolyzes Extracellular ATP....Pages 13-19
The Plasma Membrane Calcium Pump....Pages 21-26
The Cardiac Sodium—Calcium Exchange System....Pages 27-31
Molecular Properties of Dihydropyridine Sensitive Calcium Channels....Pages 33-45
Monoclonal Antibodies That Coimmunoprecipitate the 1,4-Dihydropyridine and Phenylalkylamine Receptors and Reveal the Ca 2+ Channel Structure....Pages 47-56
Criteria for Identification of α 1 and α 2 Subunits in a Purified Skeletal Muscle Calcium Channel Preparation....Pages 57-64
Phosphorylation of Dihydropyridine-Sensitive Calcium Channels from Cardiac and Skeletal Muscle....Pages 65-73
Phorbol Esters Stimulate Calcium Influx via Voltage-Dependent Channels in A 7 r 5 Vascular Smooth-Muscle Cells....Pages 75-82
Effects of cAMP-Dependent, Calmodulin-Dependent, and C-Type Protein Kinases on Platelet Calcium Transport....Pages 83-91
Molecular Structure of Canine Cardiac Phospholamban, the Regulatory Protein of Ca Pump ATPase of Sarcoplasmic Reticulum....Pages 93-101
Ca 2+ Transport by Liver and Plant Mitochondria....Pages 103-111
Front Matter....Pages 113-113
Inositol Lipids and Intracellular Communication....Pages 115-124
Receptor-Mediated Ca 2+ Signaling....Pages 125-141
Metabolism of Ins(1,3,4)P 3 by Rat Liver Homogenates....Pages 143-148
Evidence for the Existence of the Inositol Tris/Tetrakisphosphate Pathway in Rat Heart....Pages 149-156
Mechanisms of Intracellular Calcium Movement Activated by Guanine Nucleotides and Inositol-1,4,5-Trisphosphate....Pages 157-167
Activation of the Inositol-1,4,5-Trisphosphate Signaling System by Acute Ethanol Treatment of Rat Hepatocytes....Pages 169-177
Regulation of Hepatic Glycogenolysis by Calcium-Mobilizing Hormones....Pages 179-185
Receptor Desensitization Is a Major Regulator of Hormone-Induced Ca 2+ Mobilization in the Human Platelet....Pages 187-192
Front Matter....Pages 113-113
Specific Receptors for Inositol 1,4,5-Trisphosphate in Endocrine Target Tissues....Pages 193-203
Intracellular Calcium Transients Associated with Endothelium-Derived Relaxing Factor Release May Be Mediated by Inositol-1,4,5-Trisphosphate....Pages 205-210
Protein Kinase C in Rat Skeletal Muscle....Pages 211-219
Activation of Phosphoinositide-Specific Phospholipase C by Ligands in the Presence of Guanine Nucleotides....Pages 221-230
Guanine Nucleotide-Dependent Release of Arachidonic Acid in Permeabilized Inflammatory Cells....Pages 231-236
Front Matter....Pages 237-237
Measurement of Free Intracellular Calcium (Ca i ) in Fibroblasts....Pages 239-248
Growth Factors, Oncogenes, and Protein Kinase C....Pages 249-254
Insulin-like Growth Factor II Stimulates Calcium Influx in Competent Balb/c 3T3 Cells Primed with Epidermal Growth Factor....Pages 255-264
Small Cell Lung Cancer Bombesin Receptors Utilize Calcium as a Second Messenger....Pages 265-272
Extracellular Ca 2+ and Cell Cycle Transitions....Pages 273-282
Role and Properties of Ligand-Induced Calcium Fluxes in Lymphocytes....Pages 283-291
Modulation of c- fos and c- myc Expression by Effectors of Ion Movements....Pages 293-303
Regulation of c- fos Expression by Voltage-Dependent Calcium Channels....Pages 305-312
Calcium Pulses, Waves, and Gradients in Early Development....Pages 313-321
Front Matter....Pages 323-323
Calcium Ions, Hormones, and Mammalian Oxidative Metabolism....Pages 325-330
Regulation of Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Hepatocytes by Cytosolic Calcium....Pages 331-341
Calcium as a Hormonal Messenger for Control of Mitochondrial Functions....Pages 343-349
Effect of Mitochondrial Ca 2+ on Hepatic Aspartate Formation and Gluconeogenic Flux....Pages 351-360
Regulatory Effects of a Thromboxane A 2 Analogue on Hepatic Glycogenolysis and Vasoconstriction....Pages 361-368
Metabolic Regulation of Ca 2+ Handling in Permeabilized Insulinoma Cells....Pages 369-377
Front Matter....Pages 323-323
Calcium, Calmodulin, and Insulin Action in the Adipocyte....Pages 379-385
Role of Calcium in the Regulation of Mammalian Lipoxygenases....Pages 387-396
Phosphorylation and Modulation of Enzymic Activity of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase by Multiple Kinases....Pages 397-409
Origin and Role of Calcium in Platelet Activation-Contraction-Secretion Coupling....Pages 411-425
Calmodulin-like Ca 2+ -Binding Proteins of Smooth Muscle....Pages 427-437
Front Matter....Pages 439-439
Role of Ion Regulation in Cell Injury, Cell Death, and Carcinogenesis....Pages 441-449
Role of Calcium in Oxidative Cell Injury....Pages 451-461
Cytosolic Free Calcium and Cell Injury in Hepatocytes....Pages 463-470
Mechanisms of Anoxic Injury to Transport and Metabolism of Proximal Renal Tubules....Pages 471-477
X-Ray Microprobe Analysis of Subcellular Elemental Distribution in Normal and Injured Peripheral Nerve Axons....Pages 479-489
Prevention of Ischemic Brain Mitochondrial Injury by Lidoflazine....Pages 491-498
Role of Phosphoinositides in the Response of Mammalian Cells to Heat Shock....Pages 499-505
Cell Calcium in Malignant Hyperthermia....Pages 507-511
Pathogenetic Roles of Intracellular Calcium and Magnesium in Membrane-Mediated Progressive Muscle Degeneration in Duchenne Muscular Dystrophy....Pages 513-525
Front Matter....Pages 527-527
Characteristics and Functional Implications of Spontaneous Sarcoplasmic Reticulum-Generated Cytosolic Calcium Oscillations in Myocardial Tissue....Pages 529-543
Phospholipid-Calcium Relations at the Sarcolemma of the Cardiac Cell....Pages 545-550
Role of Membrane Dysfunction and Altered Calcium Homeostasis in the Pathogenesis of Irreversible Myocardial Injury....Pages 551-559
Ischemic Alterations in Mitochondrial Calcium Transport Kinetics....Pages 561-570
Structural, Biochemical, and Elemental Correlates of Injury in Cultured Cardiac Cells....Pages 571-580
Interaction of Volatile Anesthetics with Calcium-Sensitive Sites in the Myocardium....Pages 581-591
Front Matter....Pages 527-527
Cardiac Protection by Halothane Following Ischemia and Calcium Paradox....Pages 593-601
Defective Ca 2+ Functions in Protein (47-kDa) Phosphorylation and in the Coupling to Physiological Responses in Platelets from Stroke-Prone Spontaneously Hypertensive Rats....Pages 603-615
Effects of Elastin Peptides on Ion Fluxes....Pages 617-622
Back Matter....Pages 623-642