Biochemistry of Arachidonic Acid Metabolism

Front Matter....Pages i-xix
Mechanisms of Cyclooxygenase and Peroxidase Catalysis by Prostaglandin H Synthase....Pages 1-8
Lipoxygenase Mechanisms....Pages 9-39
Enzymes Synthesizing and Metabolizing Prostanoids....Pages 41-50
Enzymatic Formation of Leukotrienes....Pages 51-75
Cellular and Subcellular Compartmentation of Prostaglandin and Thromboxane Synthesis....Pages 77-93
Role of Active Oxygen in the Formation of Lipid Hydroperoxides....Pages 95-126
Peroxidatic Activation of Procarcinogens: A Role for Prostaglandin H Synthase in Initiation of Chemical Carcinogenesis....Pages 127-149
Selenium-Dependent Glutathione Peroxidase and Eicosanoid Production....Pages 151-160
Radiation Effects on Eicosanoid Formation....Pages 161-173
Phospholipases....Pages 175-193
Glucocorticoid-Induced Anti-Phospholipase Proteins....Pages 195-201
Lipid Nutrition, Prostaglandins and Cancer....Pages 203-212
Biological Effects of Hydroxy Fatty Acids....Pages 213-226
Chemotaxis....Pages 227-241
Prostanoid Receptors....Pages 243-267
Leukotrienes: Biological Properties, Evidence for Specific Receptor Sites and Evidence for the Involvement of Leukotrienes in Pathological Situations....Pages 269-285
Cyclic Nucleotides....Pages 287-296
Cell-Cell Signalling....Pages 297-309
Proteolytic Enzymes and Arachidonic Acid Metabolites....Pages 311-321
Extracellular Nucleotide Hydrolysis and Integration of Signalling....Pages 323-341
Eicosanoids and Tumor Promotion....Pages 343-373
High Pressure Liquid Chromatography of Eicosanoids....Pages 375-403
Radioimmunoassay of Eicosanoids Associated with Tumor Growth....Pages 405-416
Mass Spectrometry and Eicosanoid Analysis....Pages 417-435
Back Matter....Pages 437-442