Toxicological profiles - Tin

TOXICOLOGICAL PROFILE FOR TIN......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.2 HOW MIGHT I BE EXPOSED TO TIN?......Page 10
1.4 HOW CAN TIN AFFECT MY HEALTH?......Page 11
1.7 WHERE CAN I GET MORE INFORMATION?......Page 12
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 13
2.2.1.1 Death......Page 14
2.2.1.2 Systemic Effects......Page 18
2.2.1.6 Reproductive Effects......Page 21
2.2.2.1 Death......Page 22
2.2.2.2 Systemic Effects......Page 75
2.2.2.3 Immunological Effects......Page 82
2.2.2.4 Neurological Effects......Page 84
2.2.2.5 Developmental Effects......Page 85
2.2.2.6 Reproductive Effects......Page 86
2.2.2.8 Cancer......Page 87
2.2.3.2 Systemic Effects......Page 89
2.3.1 Absorption......Page 93
2.3.2 Distribution......Page 94
2.3.2.2 Oral Exposure......Page 95
2.3.3 Metabolism......Page 98
2.4 RELEVANCE TO PUBLIC HEALTH......Page 99
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 104
2.5.1 Biomarkers Used to Identify and/or Quantify Exposure to Inorganic Tin and Organotin Compounds......Page 110
2.7 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 111
2.9 ADEQUACY OF THE DATABASE......Page 112
2.9.1 Existing Information on Health Effects of Inorganic Tin and Organotin Compounds......Page 113
2.9.2 Data Needs......Page 116
2.9.3 On-going Studies......Page 121
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 125
4.3 USE......Page 132
5.1 OVERVIEW......Page 133
5.2.1 Air......Page 134
5.2.2 Water......Page 135
5.3.1 Transport and Partitioning......Page 136
5.3.2.2 Water......Page 137
5.4.2 Water......Page 138
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 139
5.7.1 Data Needs......Page 140
6.2 ENVIRONMENTAL SAMPLES......Page 142
6.3.2 On-going Studies......Page 150
7. REGULATIONS AND ADVISORIES......Page 151
8. REFERENCES......Page 156
Adsorption Ratio (Kd)......Page 174
Lethal Dose(LO) (LDLO)......Page 175
Reportable Quantity (RQ)......Page 176
User’s Guide......Page 177
Acronyms, Abbreviations, and Symbols......Page 182
PEER REVIEW......Page 186