Toxicological profiles - 1,2-diphenylhydrazine

TOXICOLOGICAL PROFILE FOR 1,2-DIPHENYLHYDRAZINE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.2 HOW MIGHT I BE EXPOSED TO 1,2-DIPHENYLHYDRAZINE?......Page 10
1.5 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 11
1.8 WHERE CAN I GET MORE INFORMATION?......Page 12
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 20
2.2.2.1 Death......Page 21
2.2.2.2 Systemic Effects......Page 26
2.2.2.8 Cancer......Page 29
2.2.3.6 Reproductive Effects......Page 30
2.3.1.3 Dermal Exposure......Page 31
2.3.3 Metabolism......Page 32
2.4 RELEVANCE TO PUBLIC HEALTH......Page 34
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 39
2.8 ADEQUACY OF THE DATABASE......Page 40
2.8.1 Existing Information on Health Effects of 1,2-Diphenylhydrazine......Page 41
2.8.2 Identification of Data Needs......Page 42
2.8.3 Ongoing Studies......Page 44
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 45
4.3 USE......Page 48
5.2.1 Air......Page 49
5.2.3 Soil......Page 50
5.3.2.2 Water......Page 51
5.4.1 Air......Page 52
5.4.4 Other Media......Page 53
5.7 ADEQUACY OF THE DATABASE......Page 54
5.7.1 Identification of Data Needs......Page 55
6. ANALYTICAL METHODS......Page 56
6.2 ENVIRONMENTAL SAMPLES......Page 57
6.3 ADEQUACY OF THE DATABASE......Page 58
7. REGULATIONS AND ADVISORIES......Page 59
8. REFERENCES......Page 62
Embryotoxicity and Fetotoxicity......Page 68
No-Observed-Adverse-Effect Level (NOAEL)......Page 69
Time-Weighted Average (TWA)......Page 70
User s Guide......Page 71
Acronyms, Abbreviations, and Symbols......Page 77
Peer Review......Page 80