Side-Effects of Anti-Inflammatory Drugs 3

Front Matter....Pages i-xx
The gastrointestinal toxicity of the non-steroidal anti-inflammatory drugs....Pages 1-8
The value of the case—control approach for the evaluation of the risk of upper gastrointestinal bleeding associated with the previous use of non-steroidal anti-inflammatory drugs....Pages 9-17
Liver toxicity of antipyretic drugs in conjunction with measles infections....Pages 18-21
Non-steroidal anti-inflammatory drugs and hypersensitivity reactions....Pages 22-26
What can a spontaneous reporting system teach about side-effects of anti-inflammatory drugs?....Pages 27-32
Adverse reactions to NSAIDs: Consecutive evaluation of 30,000 patients in rheumatology....Pages 33-42
The evaluation of acute gastrointestinal toxicity of NSAIDs in phase I clinical trials: a critical appraisal....Pages 43-53
The ulcerogenic and anti-haemostatic effects of NSAIDs in the gut....Pages 54-58
What role does Helicobacter pylori infection play in NSAID-associated gastric inflammation?....Pages 59-63
Endoscopic evaluation of NSAID ulceration....Pages 64-68
Food antigen absorption in rheumatoid arthritis: effect of acetylsalicylic acid....Pages 69-79
Intestinal mucosal permeability in inflammatory rheumatic diseases....Pages 80-88
Comparison of effects on gastrointestinal blood loss and gastric mucosal appearance of piroxicam-β-cyclodextrin, piroxicam and placebo....Pages 89-96
Mechanisms of gastrointestinal ulceration from non-steroidal anti-inflammatory drugs: a basis for use and development of protective agents....Pages 97-114
Novel strategies of gastric and duodenal mucosal protection against NSAID injury: role of protease inhibitors, muscle relaxants and growth factors....Pages 115-125
The role of misoprostol in preventing NSAID-induced damage to the gastrointestinal tract....Pages 126-134
Possible factors involved in the protective effects of interleukin-1 in aspirin- and indomethacin-induced gastric damage....Pages 135-144
Prevention and treatment of NSAID-gastroduodenal damage: the role of H 2 -receptor antagonists....Pages 145-153
Omeprazole in the prevention and therapy of gastroduodenal lesions on NSAID therapy....Pages 154-158
Sucralfate in the prevention of NSAID-induced gastric ulceration....Pages 159-169
Ketotifen — a novel approach to the prevention of damage in the gastrointestinal tract....Pages 170-175
The hepatotoxicity of non-steroidal anti-inflammatory drugs....Pages 176-187
Paracetamol (acetaminophen) bioactivation by liver microsomes — its role in hepatotoxicity....Pages 188-197
Increased liver toxicity of diclofenac by paracetamol: results and possible mechanisms....Pages 198-203
Effects of NSAIDs on liver microsomal mono-oxygenase system and products of oxidative metabolism of arachidonic acid....Pages 204-210
Hepatitis due to non-steroidal anti-inflammatory drugs (NSAIDs)....Pages 211-222
Current status of nephrotoxicity caused by non-steroidal anti-inflammatory drugs....Pages 223-235
Are oral prostaglandins effective in preventing nephrotoxicity from NSAIDs and cyclosporin?....Pages 236-240
Aspirin and Reye’s syndrome....Pages 241-247
Antirheumatic drug therapy in the elderly....Pages 248-260
NSAIDs and human cartilage metabolism....Pages 261-268
Non-steroidal anti-inflammatory drugs and the augmented lipoxygenase pathway: conceivable impact on joint conditions....Pages 269-274
Therapeutic potential of 5-lipoxygenase inhibitors: the discovery and development of MK-886, a novel-mechanism leukotriene inhibitor....Pages 275-286
Mechanisms of rash formation and related skin conditions induced by non-steroidal anti-inflammatory drugs....Pages 287-301
Cyclosporin: clinical efficacy and toxicity in patients with rheumatoid arthritis....Pages 302-310
Risk factors and risk—benefit problems in the use of DMARDs....Pages 311-320
Gold toxicity: chemical, structural, biological and clinical experimental issues....Pages 321-343
A review of interaction studies between non-steroidal anti-inflammatory drugs and H 2 -receptor antagonists or prostaglandin analogues....Pages 344-349
Influence of different anti-inflammatory substances on ethanol- and indomethacin induced gastrointestinal mucosal damage....Pages 350-358
The role of copper in preventing gastric damage by acetylsalicylic acid....Pages 359-362
Effect of NSAID therapy on plasma, whole blood cell (BC), and 24h urine zinc in patients with rheumatoid arthritis (RA)....Pages 363-366
Back Matter....Pages 367-376