Cell Impairment in Aging and Development

Front Matter....Pages i-xv
Cell Ageing: Chairman’s Introduction....Pages 1-5
The Effect of Hydrocortisone on DNA Synthesis and Cell Division during Aging in Vitro ....Pages 7-22
Proliferative and Functional Impairment of Pancreatic Epithelial Cells Maintained in Vitro ....Pages 23-39
The Use of Arrested Populations of Human Diploid Fibroblasts for the Study of Senescence in Vitro ....Pages 41-49
Relationship between Cell Kinetic Changes and Metabolic Events during Cell Senescence in Vitro ....Pages 51-65
Do Hyperplastoid Cell Lines “Differentiate Themselves to Death”?....Pages 67-90
Time-Lapse Cinemicrophotographic Studies of Cell Division Patterns of Human Diploid Fibroblasts (WI-38) during their in Vitro Lifespan....Pages 91-105
Characteristics of Proliferative Cells from Young, Old, and Transformed WI 38 Cultures....Pages 107-122
Alterations in Chromatin Functions during Aging in Vitro ....Pages 123-136
Growth-Promoting Alpha-Globulin and Ageing....Pages 137-146
Cell Surface Alterations and “in Vitro” Aging of Animal Cells....Pages 147-153
Changes in Lysosomes during Ageing of Parenchymal and Non-Parenchymal Liver Cells....Pages 155-169
The Effect of Age on Mitochondrial Ultrastructure and Enzymes....Pages 171-183
Creatinephosphokinase in Human Diploid Cell Lines....Pages 185-192
Cytochemical and Cytogenetic Findings in Five Human Leukocyte Long-Term Cultures (LAHL) of Different Origin....Pages 193-205
Enzymatic Differences between Short-Lived and Long-Lived Drosophila Strains....Pages 207-213
Cell Ageing in the Intestinal Tract....Pages 215-217
Studies on the Proliferative Capacity of Mouse Spleen Cells in Serial Transplantation....Pages 219-233
On the Ageing of Intermitotic Cells — Investigations on Enterocytes and Hepatocytes....Pages 235-245
Fat Cells in Ontogenesis....Pages 247-256
Ageing and the Loss of Auditory Neuroepithelium in the Guinea Pig....Pages 257-264
The Phagolysosomal System of the Retinal Pigment Epithelium in Ageing Rats....Pages 265-279
The Role of Retinol in, and the Action of Anti-Inflammatory Drugs on, Hereditary Retinal Degeneration....Pages 281-295
Effect of Age on Kidney Hyperplasia in the Rat after Unilateral Nephrectomy....Pages 297-305
Effect of Age on Kidney Hyperplasia in the Rat during Cold Acclimation....Pages 307-314
Age-Related Changes of Cells Involved in Immune Responses....Pages 315-322
Observations of Age and Environmental Influences on the Thymus Kept in Tissue Culture....Pages 323-327
Fidelity in the Collagen Synthesized and Modified by Aging Fibroblasts in Culture....Pages 329-338
Biosynthesis of Collagen during the Life Cycle of Human Diploid Cell Lines....Pages 339-350
Ageing Processes in Collagens from Different Tissues of Rats....Pages 351-357
The Effect of Nutritional Regimes Upon Collagen Concentration and Survival of Rats....Pages 359-369
Bone Aging....Pages 371-374
Relations between Development of the Capillary Wall and Myoarchitecture of the Rat Heart....Pages 375-388
Functional Capacity of Neonatal Mammalian Myocardial Cells during Aging in Tissue Culture....Pages 389-420
Ultrastructural Changes in Senile Muscle....Pages 421-429
Denervation, Reinnervation and Regeneration of Senile Muscle....Pages 431-440
Morphometrical and Mathematical Analysis of the Ageing Changes of the Muscle-Connective-Tissue-Relation in Smooth Muscles....Pages 441-449
Some Histochemical Age Changes of the Smooth Muscle Cells in the Veinous Wall....Pages 451-458
Effect of Lysolecithin on the Transport of Plasma Cholesterol to Tissues: Developmental Aspects....Pages 459-467
Viral Infection and Interferon in Cell Cultures Aged in Vitro ....Pages 469-479
Ultrastructure of in Vitro Aged Chick Embryo Cell Cultures in Relation to Viral Infection....Pages 481-495
Heritable Cell Cycle Disturbances and Late Recovery in X-Irradiated Murine Lymphoma L5178Y-S Cell Populations in Vitro ....Pages 497-509
Studies on the Sensitivity of Anticancer Agents of Normal Human Cells in Culture....Pages 511-519
Ribonucleases in mouse Ascitic Tumor Cells during Ageing in Vivo and in Vitro....Pages 521-527
Proliferation and Morphology of Ascitic Cells as a Function of Age In Cell Culture....Pages 529-542
Back Matter....Pages 543-557