Regionalized Management of Medicine (Translational Bioinformatics, 17)

Preface
Contents
About the Editors
Chapter 1: The Importance of Regionalized Management of Medicine
	References
Chapter 2: Alcohol Use Disorders: Leveraging Informatics to Improve Patient Care
	2.1 Introduction
	2.2 Use of Informatics in Laboratory Research
	2.3 Use of Informatics in Clinical Medicine
		2.3.1 Emergency Medicine
		2.3.2 Adult Inpatient Medicine
		2.3.3 Adult Ambulatory Medicine
		2.3.4 Pediatrics and Adolescent Medicine
	2.4 Use of Public Health Informatics for Alcohol Use Disorders
		2.4.1 US Public Health efforts
		2.4.2 European Public Health Efforts
	2.5 Use of Personal Devices
	2.6 Conclusion
	References
Chapter 3: Regionalized Management of Clinical Gene Sequencing in Application: An Example and Proposal of Haixi Economic Zone
	3.1 Regional Introduction
		3.1.1 Geographical Location of the Haixi Economic Zone
		3.1.2 Cultural Characteristics of the Haixi Economic Zone
		3.1.3 Public Health Development in the Haixi Economic Zone
		3.1.4 Economic Development in the Haixi Economic Zone
	3.2 Genetic Testing
		3.2.1 The Epidemiological Statistics of Genetic Diseases and Tumors in Haixi Economic Zone
		3.2.2 Current Genetic Testing in the Haixi Economic Zone
		3.2.3 Opportunities and Challenges for Genetic Testing
	3.3 Regional Management
	3.4 Consortium/Society Benefits
	References
Chapter 4: Artificial Intelligence in Medical Management
	4.1 Introduction
	4.2 AI: Definitions
	4.3 Applications of AI in Medicine
		4.3.1 Monitoring
		4.3.2 Prediction and Diagnosis
		4.3.3 Personalized Medicine
	4.4 Present and Future Challenges of Integrating AI in Healthcare Delivery
	4.5 Conclusion
	References
Chapter 5: Synthetic Lethality and Lung Cancer
	5.1 Introduction
	5.2 Expanding Definition of Synthetic Lethality
	5.3 Translating Synthetic Lethality into Therapeutics
	5.4 Synthetic Lethality and EGFRi-Resistant NSCLC
	5.5 Synthetic Lethality and KRAS-Driven NSCLC
	5.6 Conclusion
	References
Chapter 6: Advanced Demand Forecasting and Inventory Management Methods in Hospital Pharmacy
	6.1 Introduction
	6.2 Qualitative Demand Forecasting Methods
		6.2.1 Temporal Series
			6.2.1.1 Constant Approach
			6.2.1.2 Simple Moving Average
			6.2.1.3 Exponential Smoothing
			6.2.1.4 ARIMA
		6.2.2 Causal Models
			6.2.2.1 Simple Linear Regression
			6.2.2.2 Multiple Linear Regression
	6.3 Pharmacy Inventory Problem
	6.4 Predictive Control of a Pharmacy Inventory
		6.4.1 Model Predictive Control
		6.4.2 Model Predictive Control with Deterministic Demand
		6.4.3 Chance Constraints MPC
		6.4.4 Multi-scenario Approach MPC
		6.4.5 Tree-Based MPC
	6.5 Case Study and Results
		6.5.1 Demand Forecast
		6.5.2 Stochastic Model Predictive Control
	6.6 Conclusions
	References
Chapter 7: DNA Methylation in Pulmonary Inflammatory Diseases
	7.1 Introduction
	7.2 DNA Methylation and Asthma
	7.3 DNA Methylation and COPD
	7.4 DNA Methylation and Lung Cancer
	7.5 Conclusion
	References
Chapter 8: Symptom and Life Quality Management in Oncology Patients
	8.1 Symptom and Life Quality Management in Oncology Patients
	8.2 Pain
	8.3 Fatigue
	8.4 Change in Taste and Smell
	8.5 Mucositis
	8.6 Nausea and Vomiting
	8.7 Diarrhea and Constipation
	8.8 Hand-Foot Syndrome and Nail Change
	8.9 Lymphedema
	8.10 Radiotherapy Skin Reactions
	8.11 Peripheral Neuropathy
	References
Chapter 9: The Regionalization of Medical Management: The Practice and Exploration of Established Fudan-Minhang Medical Allian...
	9.1 Introduction
	9.2 Background and Basis
		9.2.1 Basic Conditions of Minhang District´s Medical Services
		9.2.2 The Basis of Fudan-Minhang Medical Alliance Establishment
			9.2.2.1 Theoretical Basis
			9.2.2.2 Practical Basis
	9.3 Exploration and Implementation of Fudan-Minhang Medical Alliance
		9.3.1 Basic Framework of Fudan-Minhang Alliance Establishment
		9.3.2 Basic Principles of Fudan-Minhang Alliance Establishment
			9.3.2.1 The Disciplines and Resources Integration
			9.3.2.2 Unified Management and Enhanced Efficiency
			9.3.2.3 Information Providing and Mode Transformation
			9.3.2.4 Mutual Beneficial Cooperation in Medical, Educational, and Research Fields
		9.3.3 The Three Models of Fudan-Minhang Alliance Establishment (Zhang et al. 2020a)
			9.3.3.1 Medical Groups
			9.3.3.2 Specialized Unions
			9.3.3.3 Remote Medical Collaboration Network
	9.4 Achievements and Considerations of Fudan-Minhang Medical Alliance
		9.4.1 Achievements of Fudan-Minhang Medical Alliance
			9.4.1.1 Implementing Oriental Functioning of Medical Institutions
			9.4.1.2 Enhancing the Sharing and Integration of the Alliance´s Resources
			9.4.1.3 Standardizing the Two-Way Referral Service Process
			9.4.1.4 Optimizing the Ability to Provide Basic Medical Services
			9.4.1.5 Promoting the Role and Signing of Family Doctors
			9.4.1.6 Establishing a Healthcare Service System that Integrates Clinical and Preventive Medicine Approaches
		9.4.2 Considerations of Fudan-Minhang Medical Alliance
			9.4.2.1 Enabling the Governmental Leading Role
			9.4.2.2 Expanding the Social Support and Sense of Identity
	9.5 Challenges and Countermeasures
		9.5.1 Challenges
			9.5.1.1 The Existing Barriers Facing the Unification of Alliance´s Resources Management
			9.5.1.2 The Unfulfilled Intelligence in Combining the Internet with Medical Care
			9.5.1.3 The Lack of Enhanced Assessment System
		9.5.2 Active Countermeasures
			9.5.2.1 The Further Enhancement of Medical Alliance´s Internal Supporting Policies
			9.5.2.2 The Thorough Development of the ``interconnection + healthcare´´ Combination
			9.5.2.3 The Deepening of Performance Assessment
	9.6 Future Development
		9.6.1 Establishing a ``Closer Medical Alliance´´
		9.6.2 Deepening the Establishment of Health Alliance
		9.6.3 Exploring the Establishment of Intelligent Health Alliance
	References
Chapter 10: Bed-Occupancy Management and Hospital Planning: A Handbook
	10.1 Introduction
	10.2 Queuing Theory
	10.3 Optimization of the Number of Beds
		10.3.1 Indifference Curves
		10.3.2 Evolutionary Computation Approach
		10.3.3 Artificial Immune System Approach
	10.4 Conclusions and Future Outlook
	References
Chapter 11: Management of Next-Generation Sequencing in Precision Medicine
	11.1 Introduction
	11.2 Workflow of Next-Generation Sequencing Experiments
		11.2.1 Sample Acquisition and Management
		11.2.2 Medical and Health Informatics
		11.2.3 Next-Generation Sequencing Techniques
		11.2.4 Bioinformatics
		11.2.5 Delivery of Results
		11.2.6 Data Storage
	11.3 Challenges in Next-Generation Sequencing
	11.4 Laboratory Information Management System
	11.5 How to Select a Laboratory Information Management System?
		11.5.1 Ability to Integrate with NGS Instrumentation
		11.5.2 Ease of Configuration and Customization
		11.5.3 Accommodativeness to Different Users
		11.5.4 Comprehensiveness of Sample Tracking
		11.5.5 Compliance Support
		11.5.6 Cost
	11.6 Examples of LIMS for NGS
	11.7 Other Issues to Consider
	11.8 Conclusion and Future Perspectives
	References
Chapter 12: Management of Severe Childhood Pneumonia in Low-Resource Setting Countries
	12.1 Background
	12.2 Epidemiology of Pneumonia
	12.3 Clinical Manifestations
	12.4 Causes
		12.4.1 Infectious Causes
		12.4.2 Non-infectious Causes
	12.5 Complications of Pneumonia
	12.6 Management
		12.6.1 Equipment and Supply Obtainability at Community-Level Health Facilities
		12.6.2 Operational Definition
		12.6.3 For Pneumonia
		12.6.4 For Severe Pneumonia
	12.7 Conclusion
	References
Chapter 13: Clinical Application of Molecular Bioinformatics
	13.1 Introduction
	13.2 Methods Suitable for Clinical Practice
		13.2.1 Weighted Gene Co-expression Network Analysis (WGCNA)
		13.2.2 Identification of Disease Subtypes
		13.2.3 The ceRNA Regulatory Network
		13.2.4 Single-Cell Sequencing
	13.3 Example of Molecular Bioinformatics in Application
		13.3.1 mRNA-MicroRNA Interaction Network
		13.3.2 Identification of Genes Associated with Open Regions of Chromatin and Super-enhancers in Lung Adenocarcinoma
	13.4 Disease Categories Based on Molecular Networks
	13.5 Conclusion
	References
Chapter 14: Being ``on a Mission´´ at Work: How to Make Mission Statements Effective in the Healthcare Sector
	14.1 Introduction: Mission in Organizations
		14.1.1 The Concept of Mission
		14.1.2 Mission Statement
		14.1.3 Mission and Stakeholders
		14.1.4 Mission´s Added Value and the Sense of Mission
	14.2 Missions in the Healthcare Sector
		14.2.1 Importance
		14.2.2 The Specific Content of Mission Statements in Healthcare Sector
	14.3 Making the Mission Effective
	14.4 Mission and Motivation
	14.5 Conclusions
	References