Life Science Management: Perspectives, Concepts and Strategies

Foreword
Preface
Contents
Editors and Contributors
	About the Editors
	Contributors
Part I: Markets and Strategies
	Development of the Life Sciences Industry over the past 30 Years
		1 ``Development of the Life Sciences Industry over the Past 30 Years´´: Development of the Life Sciences Industry over the Pas...
			Persistence
		2 ``Funding Life Science Innovations: A Venture Capital Perspective´´: In What Way Will This Development Influence Leadership ...
		3 ``Implications of Precision Medicine on Marketing and Sales Strategies´´: How recruiting has changed?
		4 ``Intellectual Property in the Life Science Field: With a Focus on Patents´´: What makes life sciences industry stand out? A...
		5 ``How AI Can Help Avoid Catastrophic Overload of Healthcare System in Times of a World-Wide Pandemic´´: An Outlook into the ...
	Funding Life Science Innovations: A Venture Capital Perspective
		1 ``Great Idea, But, ...´´: What Do Investors Pay Attention to and What Should Founders Focus on?
		2 The Team: The Challenge of Putting the Right People Together
		3 Start-Up Financing: An Ambitious Undertaking and a Considered Decision
		4 The Venture Capital Investor: How to Find the Shy Deer?
		5 The Nondisclosure Agreement: Confidence and Confidentiality
		6 Pitching a Venture Capital Investor: You Never Get a Second Chance to Make the First Impression!
		7 Due Diligence: The Phase of Getting to Know Each Other Intensively
		8 The Term Sheet: Fundamentals for a Successful Contract Negotiation
		9 The Participation Agreement: The Starting Point of a Close Relationship for a Period of Time
		References
	Implications of Precision Medicine on Marketing and Sales Strategies
		1 The One Fits-Not-All Business Model of Pharma
		2 What Is Precision Medicine?
		3 The Impact of Precision Medicine on Healthcare Provision
		4 Marketing and Sales Approach in Pharma Today
		5 Successful Marketing in Precision Medicine
			The Role of the Patient and Direct-to-Consumer Advertising (DTCA)
			Limitations to International Launch Campaigns
			Medical Marketing and the Role of Networks
			New Pricing Models
		6 Conclusion
		References
	Intellectual Property in the Life Science Field: With a Focus on Patents
		1 Introduction
		2 Own Patents
			Why Patents?
			What Can Be Patented?
			First File Then Publish!
			Structure of a Patent Application
			Typical Proceedings
			Typical Timelines
			Numbers, Patent Families, and Data Sources
			My Patent Was Granted: What Can I Do Now?
			Funding Opportunities
			Territorial Scope of a Patent
			Entitlement to the Invention
		3 Third-Party Intellectual Property
Part II: Technology and Data
	How AI Can Help Avoid Catastrophic Overload of Healthcare System in Times of a Worldwide Pandemic
		1 Health Systems Are Generally Overstretched, and the Pandemic Has Proven This
		2 AI Technology Shifts the Paradigm on How Humanity Functions
		3 AI in Healthcare Management
			AI Helps to Mitigate Workforce Shortage and Saves Resources
				AI augments Healthcare Personnel Work from Nurses to Managers
				AI Reduces Waste Due to Logistical and Procedural Overhead
			Risks of AI in Healthcare and Mitigation
				Ethics
				Data Privacy
				Challenges Related to Machine Learning Algorithms
				The Long-Tail and Corner Cases
		4 Summary and Outlook
		References
	Event-Driven Architecture for a Medical Records System
		1 Patient´s Record
		2 Centralized System of Medical Records
			Data Need to Be Secure
				Data at Rest
			Zero Trust Environment
		3 Event-Driven Decentralized System
			Event Bus
			Asking for Clearance
			Presenting the Clearance
		4 Nonfunctional Requirements and the Event-Driven System
			Different User Groups
			Data at Rest Encrypted
			Requirements of GDPR
			Separation of Concerns
			Zero-Trust Architecture
			Different Types of Data
		5 Summary
		References
	Hospitals of the Future: How Can We Get There?
		1 What Will Hospital Services Look Like in the Coming Years?
		2 Stimuli for the Hospital of the Future
		3 Fields of Action
			The Admission and Discharge Processes
			Electronic Medical Records (EMR)
			Hospital Operations in the Future
			What About Patients´ Experiences of the Hospital of the Future?
			Personal Care
			Logistics in the Hospital of the Future
			Potential of Blockchain Technology in the Hospital of the Future
			Human Resources Planning
			Virtual Teaching and Training
			The Hospital as a Place for Well-Being
		4 The Modern Digital Hospital
			Digital Care
			Digital Customer Experience
			Digitalised Operations
		5 Conclusion
		References
Part III: Change and Innovation
	Life Science Management as a Multidisciplinary Challenge in Global Innovation Competition
		1 Bureaucracy Blocking the Way to Innovation
			Example: The Medical Technology Industry
			Example: Biotechnology
			Example: Mechanical and Plant Engineering
				Conclusion and Possible Courses of Action to Promote Innovation
		2 Strategic Embedding of Life Sciences with Other Key Technologies
			Cybersecurity and Cryptography
				Cases of Cybercrime in Recent Years
			Artificial Intelligence
			Biotechnology and Synthetic Biology
			Smart Factory
			3D Printing
				History of 3D Printing
				3D Printing in Medicine
				Conclusion and Possible Courses of Action to Promote Innovation and the Strategic Embedding of Life Sciences
		References
	Trust and Incentives in Driving a Collaborative Innovation: South Korean Life Science Industry
		1 Definition of the Terms
		2 Introduction
			Box 1 Understanding Ecosystem
			The Motivation of the OI System in the Life Science Innovation Process
				Box 2 ``Research Translation Process´´ in the Life Science Innovation
		3 Trust and Incentives Among Actors During the Research Translation Process in Korean Life Science Innovation
			Box 3 ``Trust´´ in the Life Science Innovation
			Box 4 ``Incentives´´ in the Life Science Innovation
			Meaning of Trust and Incentive to Actors in the Korean Life Science Innovation System
		4 Current Challenges in Korean Life Science Innovation
			The General Overview of the Korean Innovation Scenario
				Box 5 Input of Each Actor´s Capability in the Research Translation Process
			Collaboration, Trust, and Incentives in Korean Life Science Innovation
			KRT Management in Korean Life Science Innovation
		5 Designing the Effective Collaboration Space in the Research Translation Process
			Trust and Incentive Scheme Learned from the Case Studies
				Box 6 Lesson from the Case study 1
				Box 7 Lessons from the case studies 2 and 3
			The Conceptual Space Model and the Proposed Collaboration Scheme for Korean Life Science Innovation
				Box 8 The defined characteristics of critical attributes and the undesirable outcomes
			Summary of the Recommendation
		References
	Drivers for Changes in the Evidence Generating Network for Biopharmaceuticals: The Impact of the COVID Pandemic
		1 Introduction
		2 Current Developments Affecting the Evidence Generating Network for Biopharmaceuticals and Its Value Chains
			Better Understanding of Disease Biology and Genetics
			Availability of Real World Data from Various Sources
			Availability of Digital and Mobile Health Technologies
			Demographic Change
			Low R&D Productivity of Biopharmaceutical Companies
			Horizontal and Vertical Expansion and Market Consolidation Within R&D Service Providers
			Further Globalization of Pharmaceutical R&D and Production
			Implementation of New Research Collaboration and Funding Models
		3 Conclusion
		Appendixes
			Appendix 1: M & A Activities of Top 10 CROs (2015-June 2021)
			Appendix 2: Top 10 CRO Partnerships and Collaborations (2012-2021)
		References
	Open Innovation in the Life Science Industry
		1 Open Innovation: Concept, Principles, and Relevance
			Open Innovation Concept
			Open Innovation Principles
			Outside-In Process
			Inside-Out Process
			Coupled Process
			Open Innovation Relevance
		2 The Power of Networking and Collaborations
		3 Early Adoption of OI in R & D Management
		4 A Very Special Asset in LS: OI and IPR Management
		5 Intrapreneur, Entrepreneur, and Leadership
		References
Part IV: Leaders and Entrepreneurs
	Ludic Leadership: The Counter-Intuitive Case for Playing Games in the Life Science Industry
		1 Ludic Leadership: The Counter-Intuitive Case for Playing Games in the Life Science Workplace
			A Ludic Leader Uses Games for Situational Workplace Interventions
			A Ludic Leader Uses Games to Structure the Workplace Environment
			A Ludic Leader Is Personally Transformed by a Playful Leadership Journey
		2 The Ludic Workplace Experience
			Perceived Usefulness
			Job Relevance
			Image and Social Status
			Affiliation
			Rewards
			Punishment
			Arousal and Challenges
			Enjoyment and Entertainment
			Flow and Immersion
			Playfulness
		3 Conclusion
		References
	Learning to Lead: A Non-profit Organization Perspective
		References
	Setting Up a Company in the Life Science Sector
		1 Biotechnology Combines Sustainability and Future Orientation
		2 Definition of Bioeconomy by the German Bioeconomy Council
		3 Biotechnology as a Cross-sectional Technology
		4 Biotechnology as an Opportunity for StartUps
		5 The Business Plan for the Preparation of the Foundation
		6 Startup Idea and Business Model
		7 Property Rights: Essential for Biotechnology Companies
		8 Founding Team and Networking
		9 Financing
		10 Location Requirements
		11 Biotechnology: A Well-Organized Industry
		Special terms
		References