Women's vascular health

 Content: Preface Outstanding Achievement Award - Dr. Alan S. Cohen Symposium Keynote Address - Dr. Stanley Prusiner Report of the Nomenclature Committee   MECHANISMS OF FIBRIL FORMATION AND CELLULAR RESPONSE KEYNOTE ADDRESS:  The Effect of Membranes and Surfaces on the Fibrillation of an Amyloidogenic Light Chain:  Relevance to the Etiology of Al Amyloidosis, X. Meng, M. Zhu, and A.L. Fink  Heparan Sulfate Promotes the Refolding and Oligomerization of SAA1.1:  A Short Sequence is Implicated in this Misfolding Process, J.B. Ancsin, E. Elimova, and R. Kisilevsky  Mouse Senile Amyloidosis:  Possible Horizontal Transmission in the Mouse Room, X. Fu, T. Korenaga, J. Yan, F. Ge, B. Zhang, J. Qian, H. Naiki, J. Sawashita, M. Mori, and K. Higuchi  Charge Differences of Deposits in AL and NALCDD, B. Kaplan, A. Livneh, and G. Gallo  Role of the C-terminal Amino Acids in ss2-Microglobulin Amyloid Formation, J. Kim, Y. Motomiya, M. Nakamura, M. Ueda, S. Saito, Y. Misumi, S. Himeno, K. Obayashi, S. Shinriki, W. Meng, U. Semba, H. Kai, and Y. Ando  Serum Amyloid A Generates High-Density Lipoprotein from Human Aortic Smooth Muscle Cells, Y. Kumon, S. Abe-Dohmae, S. Yokoyama, and T. Sugiura  Amyloid Light Chains Localize to Lysosomes and Cardiac Fibroblasts Show Reduced Mitochondrial Function, G. Monis, J. Eberhard, L.H. Connors, M. Skinner, and V. Trinkaus-Randall  Cerebrospinal Fluid and Plasma of Alzheimer Patients Promote ss-Amyloid Fibril Formation In Vitro, K. Ono, M. Noguchi-Shinohara, M. Samuraki, Y. Matsumoto, D. Yanase, K. Iwasa, H. Naiki, and M. Yamada  A Novel Assay for Detection of Amyloid Induced Apoptosis, J.F. Paulsson, S.W. Schultz, M. Kohler, I. Leibiger, P.-O. Berggren, and G.T. Westermark  Human Amyloidogenic Immunoglobulin Light Chains Alter Cardiomyocyte Signaling and Disrupt Heparan Sulfate Proteoglycan (HSPG) Expression, X. Peng, E. Kim, T. Miller, G. Karamitis, L.H. Connors, M. Skinner, and D.B. Sawyer  GAGs Associated with Fibril Extracts Mediate Fibrillogenesis in AL Amyloidosis, R. Ren, Z. Hong, L.H. Connors, M. Skinner, C.E. Costello, and V. Trinkaus-Randall  Decorin in AA Amyloidosis, T.N. Wien, R. Sorby, T. Landsverk, and G. Husby  Structural Evolution of Immunoglobulin Light Chain during Amyloid Fibril Formation:  A Deep UV Resonance Raman Spectroscopic Study, M. Xu, E.M. Baden, K.M. Jasmin, M. Ramirez-Alvarado, and I.K. Lednev   AA AND LOCALIZED AMYLOIDOSES KEYNOTE ADDRESS:  AA Amyloidogenesis:  Basic and Translational Research, R. Kisilevsky and W.A. Szarek   Histochemical and Immunohistochemical Characteristics of Amyloid Deposits, A. Apathy and M. Bely  Ultrastructural Characteristics of Amyloid Deposits, M. Bely, A. Apathy, and P. Kapp  Odontogenic Feline and Canine Tumor-Associated Amyloid is Formed from Ameloblastin, R. Donnell, C.L. Murphy, M. Eulitz, T.K. Williams, S.D. Macy, D.T. Weiss, and A. Solomon  Amyloidogenic Region of Odontogenic Ameloblast Associated Protein (ODAM), J.S. Foster, D.P. Kestler, C.L. Murphy, S.J. Kennel, J.S. Wall, D.T. Weiss, and A. Solomon  What is the Best Way to Assess Predisposition to AA Amyloid in Inflammatory Joint Disease?, J.A. Hunter, R.D. Baxter, A. Stirling, J. France, F. Varyani, and M.S. Mak  Advances in Non-Invasive Imaging of AA Amyloid in Mice, S.J. Kennel, T. Richey, J.S. Avenell, P.N. Hawkins, A. Solomon, and J.S. Wall  Detection and Identification of Amyloid Deposition Associated with Human Unerrupted Tooth Follicles, D.P. Kestler, J. Hudson, S.D. Macy, C.L. Murphy, J.S. Foster, D.T. Weiss, and  A. Solomon  Vascular AA Amyloid Formation Modeled in Cell Culture, B. Kluve-Beckerman  Amyloidosis in Ankylosing Spondylitis - Unexpected Findings Underscoring the Importance of Typing of Amyloid Deposits, D. Kracker, N.O. Litbarg, and M.M. Picken  Lack of Correlation Between Amyloid A Protein Levels and Clinical Parameters in Aspirated Fat Tissue of Familial Mediterranean Fever Patients with Secondary Amyloidosis, M. Lidar, B.P. Hazenberg, J. Bijzet, W. Hauck, D. Garceau, R. Kedem, and A. Livneh  Chronic, Slowly Progressing Nephropathy Due to Amyloidosis of CSAA (SAA4) Origin, R.P. Linke, S. Adler, U. Hegenbart, S. Schonland, J. Lutz, F.C. deBeer, and H.-J. Grone  Redistribution, Clearance and Re-induction of Amyloid in Reactive Murine AA Amyloidosis, S.N. Nystrom and G.T. Westermark  N-Formyl Peptide Receptor-Like 1 of the Neutrophils in the AA-Amyloidosis Tissues is Less Stained, E. Ohara, Y. Kumon, and T. Sugiura  AL in the Clinical Setting of AA:  The Importance of Amyloid Typing, K. Oshima, D. Kracker, and M.M. Picken  Foie Gras is a Dietary Source of AEF, T. Richey, C.L. Murphy, J.S. Wall, G.T. Westermark, P. Westermark, D.T. Weiss, and A. Solomon  The Effect of a Variety of Anti-Inflammatory Drugs on Murine Amyloidogenesis, S. Shtrasburg, M. Lidar, M. Pras, R. Gal, and A. Livneh  Translocation of Systemic Amyloidosis by Peripheral Blood Monocytes, J. Sponarova, S.N. Nystrom, and G.W. Westermark  FK506 Inhibits Murine AA Amyloidosis Without Modulating Serum SAA Levels, M. Ueda, Y. Ando, M. Nakamura, T. Yamashita, K. Obayashi, Y. Misumi, S. Shinriki, A. Ueda, R. Zeledon, S. Himeno, S. Saito, J. Kim, W. Meng, and M. Uchino  Local Tumorous AA-Amyloid Deposition in a Case of Hepatic Adenomatosis:  Immunohistochemistry and In Situ Hybridization Employing SAA-mRNA Probes, S. Urieli-Shoval, P. Flemming, M. Stolte, and R.P. Linke  SAA4-Related AA Amyloidosis, S. Wang, C.L. Murphy, D. Kestler, S.D. Macy, T.K. Williams, D.T. Weiss, and A. Solomon  Measurement of Amyloidogenic SAA Isotype, SAA1, T. Yamada, and Y. Okuda   FAMILIAL AND TTR AMYLOIDOSES In Vitro and In Vivo Effects of Genistein on TTR Stabilization and Aggregation, M.R. Almeida, I. Cardoso, N. Ferreira, and M.J. Saraiva  Labial Salivary Gland Biopsy for Diagnosis of Amyloid Polyneuropathy Portuguese Type, B. Amaral, T. Coelho, and A. Guimaraes  Hereditary Gelsolin Amyloidosis in an Iranian Family:  The First Report from the Middle East, M.R. Ardalan, M.M. Shoja, T. Paunio, S. Tanskanen, S. Kiuru-Enari, A. Rastegar, and M. Kashgarian  A Case of Compound Heterozygosity in a Nigerian Male with Identification of a New Transthyretin Variant Phe44Leu and Val122Ile, C.T. Barry, T. Prokaeva, P. Soohoo, B. Spencer, D. Pimental, and L.H. Connors  Suppression of HepaticT synthesis by Antisense Oligonucleotides, M.D. Benson and B. Kluve-Beckerman    Top-Down Mass Spectrometry Analysis of Amyloidogenic Proteins, C.E. Costello, R. Theberge, C. Lin, J. Kingsbury, E. Klimtchuk, L.H. Connors, M. Skinner, D.C. Seldin, and P.B. O\'Connor  ATTR (Thr59Lys) Amyloidosis with Involvement of Heart, Peripheral and Autonomic Nervous System, Gut and Salivary Glands in an Egyptian Man, Previously Diagnosed as \"Familial Amyloid Neuropathy of Portuguese Type\", G.E. Feurle, J.J. Liepnieks, M.D. Benson, and R.P. Linke  Systemic Amyloidosis of Fibrinogen Origin in the Wild Living Stone Marten (Martes Foina), O. Geisel, R. Mentele, F. Lottspeich, and R.P. Linke  Familial Amyloid Nephropathy of Fibrinogen Aa (E526V) Origin.  Report of the First Case from Austria, S. Hargassner, G. Biesenbach, G. Syre, K. Altland, and R.P. Linke  Laryngeal Amyloidosis in Patients with Apolipoprotein AI I174S and I178P, A.J.C. Hazenberg, F.G. Dikkers, P.N. Hawkins, J. Bijzet, D. Rowczenio, M.D. Posthumus, M.K. Leijsma, J. van der Wal, and B.P.C. Hazenberg  Hereditary Fibrinogen A a-Chain Amyloidosis:  Clinical Features and the Curative Role of Liver Transplantation, N.D. Heaton, J. O\'Grady, M. Rela, P. Muiesan, J.A. Wendon, L. Sizer, J. Sedgwick, M. Thoma, F. Murgatroy, C.J. Mathias, H.J. Goodman, D. Rowczenio, A. Bybee, G. Tennent, P.N. Hawkins, and A.J. Stangou  Amyloidosis in the Transgenic Mice of Mouse Amyloidogenic Apolipoprotein A-II (apoa2c), K. Higuchi, F. Ge, X. Fu, J. Yao, Z. Guo, J. Yan, B. Zhang, H. Zhang, J. Qian, J. Sawashita, and M. Mori  Urinary Transthyretin:  A Possible Biochemical Marker in the Early Stage of Renal Dysfunction, S. Himeno, M. Ueda, M. Nakamura, T. Yamashita, K. Obayashi, X. Sun, Y. Misumi,  S. Shinriki, A. Ueda, Y. Uji, S. Saito, J. Kim, W. Meng, and Y. Ando  Unique Phenotype of Vitreous Amyloidosis in Different Endemic Areas, N. Kakizoe, Y. Ando, T. Kawaji, E. Ando, O. Sandgren, O.B. Suhr, and H. Tanihara  Composition of Peripheral Nerve Amyloid after Orthotopic Liver Transplant for FAP, J.C. Kincaid, J.J. Liepnieks, and M.D. Benson  Characterization of Fibrillar Transthyretin in Ex Vivo Cardiac Deposits from Cases of Senile Systemic Amyloidosis, J.S. Kingsbury, R. Theberge, C.E. Costello, and L.H. Connors  Comparison of Cardiac Amyloidosis Associated with Wild Type Transthyretin and the Isoleucine 122 Variant, H.J. Lachmann, H.J.B. Goodman, J.D. Gillmore, A. Wechalekar, D.M. Rowczenio, A. Bybee, and P.N. Hawkins  AL Amyloidosis in a Patient with a T60A TTR Mutation, H.J. Landau, R.L. Comenzo, P. Zhou, B. Clark, J. Teruya-Feldstein, S. Wang, C.L. Murphy, and A. Solomon  Biochemical Characterization of Leptomeningeal Amyloid in a Val30Gly Transthyretin Patient, J.J. Liepnieks, S. Vakili, and M.D. Benson  Apolipoprotein A-I (apo A-I) Nature of Knee Joint Meniscus-Associated Amyloid, S.D. Macy, T.K. Williams, C. Wooliver, C.L. Murphy, S. Wang, D. Kestler, P. Westermark, D.T. Weiss, and A. Solomon   An Autopsy Case of Familial Amyloidotic Polyneuropathy ATTR Val30Met 10 Years After Liver Transplantation:  Changes in the Amount of Amyloid Deposits in the Pancreas, Y. Misumi, Y. Ando, M. Nakamura, T. Yamashita, S. Himeno, M. Ueda, X. Obayashi, X. Sun, S. Saito, J. Kim, S. Shinrik, W. Meng, A. Ueda, and M. Uchino  Amyloid Neuropathy in a Japanese Domino Liver-Transplanted Recipient, K. Obayashi, T. Yamashita, M. Ueda, M. Nakamura, K. Asonuma, Y. Inomata, M. Uchino, K. Tanaka, and Y. Ando  The Natural History of Hereditary Apolipoprotein A-I Amyloidosis According to a Large Series of Italian Leu75Pro Patients, L. Obici, G. Gregorini, F. Scolari, l. Calabresi, T. Scalvini, S. Donadei, and G. Merlini  Domino Liver Transplantation Using the Explanted Grafts from Patients with Hereditary Forms of Amyloidosis:  The King\'s College Hospital Experience, J. O\'Grady, M. Rela, P. Muiesan, M. Bowles, R. Williams, P.N. Hawkins, N.D. Heaton, and A.J. Stangou  Cardiomyopathy in FAP Val30Met Patients With and Without Liver Transplantation, S. Okamoto, T. Yamashita, Y. Ando, and M. Uchino  Detection of Cardiac Pre-Amyloid Deposits of Transthyretin by MALDI-TOF, R.N. Picken, M. Morgan, and M.M. Picken  Effect of Nitric Oxide in Transthyretin-Related Amyloidosis, S. Saito, Y. Ando, M. Ueda, J. Kim, M. Nakamura, T. Yamashita, K. Obayashi, Y. Misumi, S. Shinriki, S. Himeno, W. Meng, Y. Ishima, T. Akaike, and M. Otagiri  Inhibition of Intracellular Tetramerization Induces the Proteasomal Degradation of Amyloidogenic Transthyretin Variants, T. Sato, S. Susuki, M. Miyata, Y. Ando, T. Shuto, M.A. Suico, and H. Kai  Structural Analyses of Fibrinogen Aa-Chain Amyloid Fibrils, L.C. Serpell, M.D. Benson, J.J. Liepnieks, and P.E. Fraser  A Transthyretin Mutation (V32A) in an Israeli Patient with Amyloidotic Neuropathy Localizes to a 3-D Mutation Cluster, Y. Shinar, B. Kaplan, C. Avisar, and A. Livneh  Amyloid Deposition in the Tongue of Patients with Familial Amyloidotic Polyneuropathy, S. Shinriki, M. Ueda, T. Yamashit, K. Obayashi, X. Sun, S. Himeno, A. Ueda, Y. Misumi, S. Saito, J. Kim, W. Meng, M. Shinohara, and Y. Ando  Recent Novel and Rare Mutations in a Clinic Population of Patients with Amyloidosis, B. Spencer, L.H. Connors, T. Prokaeva, P. Soohoo, C. O\'Hara, and M. Skinner  Proliferation of Smooth Muscle Cells in the Tunica Intima of Cerebral Vessels in Familial Amyloidtic Polyneuropathy ATTR Y114C, A. Ueda, M. Ueda, T. Yamashita, T. Hirano, M. Nakamura, Y. Misumi,  W. Meng, T. Ito, M. Uchino, and Y. Ando  Reengineering TTR Amyloid Inhibition Properties of Diflunisal, M. Vilaro, G. Arsequell, G. Valencia, A. Ballesteros, J. Barluenga, J. Nieto, A. Planas, R. Almeida, and M.J. Saraiva  Familial Amyloidosis Associated with a Novel Mutation (D68G) in the Lysozyme Gene, C. Wooliver, D. Coriu, C.L. Murphy, D.P. Kestler, S. Wang, D.T. Weiss, and A. Solomon  Effects of Liver Transplantation on Hereditary Cerebral Amyloid Angiopathy Associated with ATTR Y114C, T. Yamashita, Y. Ando, M. Ueda, M. Nakamura, S. Okamoto, T. Hirahara, A. Ueda, Y. Misumi, K. Obayashi, and M. Uchino  Effect of Tacrolimus and Cyclosporine on Transthyretin (TTR) Metabolism in Rats:  A Long Term Analysis, R. Zeledon, Y. Ando, K. Asonuma, M. Nakamura, M. Ueda, X. Sun, J. Fujii, and Y. Inomata   AL AMYLOIDOSIS KEYNOTE ADDRESS:  Can AL Amyloidosis Be Cured?, D.C. Seldin  Identification of Novel Inhibitors of Light Chain Fibrillogenesis, L. Acero, A. Solomon, J.S. Wall, and B. O\'Nuallain  Peptide Phage Display and Epitope Mapping of a Fibril-Related Conformational Epitope Recognized by the 11-1F4 Monoclonal Antibody, A. Allen, S.J. Kennel, A. Solomon, J.S. Wall, and B. O\'Nuallain  The Translocation t(11;14) Is Frequently Detected in Patients with AL Amyloidosis, T. Bochtler, S.O. Schonland, F. Cremer, D. Hose, M. Moos, C. Bartram, A.D. Ho, H. Goldschmidt, A. Jauch, and U. Hegenbart  ALBASE:  A Platform Analysis Tool for the Study of Amyloid Light Chain Sequence Data, K.L. Bodi, M. Kaut, B. Spencer, F. Lavatelli, C. Costello, L.H. Connors, M. Skinner, and D.C. Seldin  Risk-Adapted Melphalan with Stem Cell Transplant (SCT) and Adjuvant Dexamethasone (DEX) +/- Thalidomide (THAL) Achieves Low Treatment-Related Mortality and High Hematologic Response Rates, A.D. Cohen, P. Zhou, L. Reich, H. Hassoun, J. Teruya-Feldstein, D.A. Filippa, B. Clark, M. Stubblefield, M. Fleisher, S.D. Nimer, and R.L. Comenzo  A Supervised Analysis of Gene-Expression Profiles of Purified Clonal Plasma Cells From Patients with Systemic Light-Chain Amyloidosis (AL) Who Have High or Low Levels of Serum Free Lambda Light Chains, R.L. Comenzo, P. Zhou, M. Fleisher, and A.B. Olshen  Comparison of Immunoglobulin Light Chains (?1):  Amyloidogenic vs. Non-Amyloidogenic Proteins, L.H. Connors, J. Eberhard, B. Spencer, T. Prokaeva, Y. Jiang Y, M. Budnik, R. Theberge, D.C. Seldin, C.E. Costello, and M. Skinner  Clinicopathological Analysis of Thirty-Two Patients with AL Amyloidosis:  Four-Years Experience in a Single Institution, D. Coriu, C. Dobrea, M.Dogaru, S. Zamfir, E. Stoica, C. Macarie, M. Voiculescu, C. Ionescu, R. Bobeica, C. Valciu, G. Becheanu, M. Manuc, A.Tanase, S.Varady, and D. Colita  Role of Light Chain Deamidation in the Pathogenesis of AL Amyloidosis, M. Eulitz, C.L. Murphy, D.T. Weiss, and A. Solomon  The Extent and Distribution of Amyloid in 38 Autopsies on Patients with Primary (AL) Amyloidosis, J. Gan, L.H. Connors, M. Skinner, and C.J. O\'Hara  Transplantation without Growth Factor Engraftment Kinetics Following Stem Cell Transplantation for Primary Systemic Amyloidosis, M.A. Gertz, M Q. Lacy, A. Dispenzieri, S.R. Hayman, S.K. Kumar, and D. Gastineau  Extent of Hematologic Response is Important in Determining Outcome in Transplanted Patients with Primary Systemic Amyloidosis.  Importance of Achieving a Complete Response, S.R. Hayman, M.Q. Lacy, A. Dispenzieri, S.K. Kumar, D.A. Gastineau, and M.A. Gertz  A Single-Center Experience Using Chemotherapy with Melphalan-Dexamethasone (M-dex) in Patients with AL Amyloidosis and Advanced Organ Involvement Not Eligible for High-Dose Melphalan Therapy (HDM), U. Hegenbart, T. Bochtler, J.B. Dengler, M. Hundemer, A.D. Ho, H. Goldschmidt, and S.O. Schonland  Detection and Characterization of AL Light Chain Proteins from Fibrils, Z. Hong, R. Theberge, A. Lim, T. Prokaeva, L.H. Connors, M. Skinner, and C.E. Costello  Characterization of Post-Translational Modifications of an Amyloidogenic Immunoglobulin Kappa Light Chain by Mass Spectrometry, Y. Jiang, R. Theberge, J. Eberhard, G. Karamitis, T. Prokaeva, L.H. Connors, M. Skinner, C. Lin, P.B. O\'Connor, and C.E. Costello  Involvement of Lysosomes in Renal AL-Amyloidogenesis, J. Keeling, and G.A. Herrera  Thermal Unfolding of Immunoglobulin Light Chains is Linked to Aggregation:  Circular Dichroism and Light Scattering Studies, E.S. Klimtchuk, O. Gursky, J. Eberhard, L.H. Connors, and M. Skinner  Prognostic Relevance of Serum N-Terminal Pronatriuretic Peptide Type B and Plasma BNP in Patients with AL Amyloidosis in Dialysis, M. Nuvolone, G. Palladini, F. Lavatelli, P. Russo, V. Perfetti, S. Perlini, L. Obici, F. Clari, and G. Merlini  AL Amyloidosis in the Elderly:  A Review of 330 Patients, M. Offer, A.D. Wechalekar, H.J. Lachmann, J.D. Gillmore, and P.N. Hawkins  Therapeutic Potential of Naturally Occurring Fibril-Reactive Human Antibodies for AL Amyloidosis, B. O\'Nuallain, A. Allen, T. Richey, J.S. Wall, D.T. Weiss, and A. Solomon  Prolonged Follow-Up Study of AL Patients Ineligible for Stem Cell Transplantation Treated with Oral Melphalan and Dexamethasone, G. Palladini, F.  Lavatelli, P. Russo, M. Nuvolone, V. Perfetti, L. Obici, and G. Merlini  Left Ventricular Systolic Function in Patients with Cardiac AL Amyloidosis, S. Perlini, M. Vezzoli, F. Clari, G. Palladini, P. Russo, M. Nuvolone, and G. Merlini  In Vitro Silencing of Amyloidogenic ?6 Light Chain Production, J.E. Phipps, J.S. Foster, D.P. Kestler, A. Solomon, and J.S. Wall  Amyloid Typing in Surgical Pathology:  Experience of a Single Institution, M.M. Picken  Somatic Mutations Create Potential N-Glycosylation Sites in the Immunoglobulin Light Chain Variable Regions in Primary Amyloidosis, T. Prokaeva, B. Spencer, G. Doros, K. Bodi, J. Eberhard, Y. Jiang, M. Budnik, R. Theberge, C.E. Costello, L.H. Connors, M. Skinner, and D.C. Seldin  A Trial of Antioxidants to Improve Cardiac Function in Patient with AL Amyloidosis and Cardiac Involvement, M. Rosenzweig, D. Sawyer, F. Ruberg, D. Wright, V. Sanchorawala, D. Seldin, J. Vita, R. Lala, D. Brenner, F. Sam, and M. Skinner  High-Dose Melphalan Chemotherapy with Autologous Stem Cell Transplantation in 65 Patients with AL Amyloidosis:  Organ Progression Can Be Delayed in Patients Reaching Complete Remission, S.O. Schonland, J.B. Dengler, M. Hundemer, T. Bochtler, R. Singer, E. Hund, J. Beimler, M. Zeier, A.V. Kristen, T.J. Dengler, A.D. Ho,  H. Goldschmidt, and U. Hegenbart  Glycosylated Amyloid and Non-Amyloid Associated Lambda Light Chains, K. Sletten, S. Wang, C.L. Murphy, F.J. Stevens, D.T. Weiss, and A. Solomon  Extramedullary Production of AL Amyloid Precursor Protein, A. Solomon, D.T. Weiss, S.D. Macy, C. Wooliver, and P. Westermark  Mesangial Amyloid Formation in an Isolated Rat Kidney Perfusion Model:  A New Model to Study Renal Amyloidogenesis, J. Teng and G.A. Herrera  Overexpression of Calreticulin in Clonal Al Plasma Cells is Associated with Response to Melphalan and Autologous Stem Cell Transplant in Systemic Light-Chain (AL) Amyloidosis, J. Teruya-Feldstein, P. Zhou, A.B. Olshen, and R.L. Comenzo  Semi-Quantitative Assessment of Amyloid in Congo Red-Stained Subcutaneous Abdominal Fat Tissue in Systemic Amyloidosis and Disease Severity, I.I. van Gameren, B.P.C. Hazenberg, J. Bijzet, E. Brouwer, M.D. Posthumus, and M.H. van Rijswijk  Imaging Human AL Amyloid in Mice Using the Fibril-Reactive Monoclonal Antibody 11-1F4, J.S. Wall, S.J. Kennel, T. Richey, J.S. Avenell, and A. Solomon  Tandem Mass Spectrometry and Other Methods Identify Apolipoprotein E3 and Kappa 1 Light Chain in Amyloid Fibrils Extracted from a Patient with AL Amyloidosis, L. Wang, X. Yuan, B. Clark, N. Lampen, H. Deng, Y. Zhang, and R.L. Comenzo  Mouse Models of AL Amyloidosis, J.E. Ward, D. Brenner, P. Soohoo, L. Cui, R. Liao, X. Peng, D. Sawyer, L.H. Connors, T. Christensen, C. O\'Hara, M. Skinner, and D.C. Seldin  NT-ProBNP in AL Amyloidosis:  Association with Survival and Changes After Chemotherapy, A. Wechalekar, H. Lachmann, J. Gillmore, M. Offer, J. Joshi, and P. Hawkins  Histochemical-Based Staging System for AL Amyloidosis, D.T. Weiss, C. Wooliver, and A. Solomon  Localized AL Amyloidosis:  A Distinctive Clinicopathologic Disorder, T.K. Williams, S.D. Macy, C. Wooliver, C.L. Murphy, P. Gorevic, P. Westermark, D.T. Weiss, and A. Solomon  Evaluation of Plasma Cell Volume and Clonality in AL (primary) Amyloidosis by Analysis of Pre and Post Stem Cell Transplantation Bone Marrow Core Biopsies (BMCB), H. Xu, P. Soohoo, G. Doros, M. Skinner, and C. O\'Hara  Biochemical Characterization of Amyloid from a Rectal Amyloidoma, Z. Zaky, O. Cummings, J.J. Liepnieks, D. Rex, and M.D. Benson   NEW DIAGNOSTICS AND EMERGING TRANSLATIONAL APPROACHES KEYNOTE ADDRESS:  Advances in Systemic Amyloidoses:  From Mechanisms to Better Care, G. Merlini  The Diagnosis of Amyloidosis May Be Hindered by the Sampling Error, and How to Prevent It, M. Bandmann and R.P. Linke   Serum Amyloid P Component (SAP) Concentration in Abdominal Fat Aspirates of Patients with Amyloidosis, J. Bijzet, B.P.C. Hazenberg, P.N. Hawkins, M.K. Leijsma, E. Brouwer, M.D. Posthumus, and M.H. van Rijswijk  Biochemical Characterization of Amyloid by Endomyocardial Biopsy, J. Breall, M.D. Benson, J.J. Liepnieks, and O. Cummings  A Peptide-Based Vaccine Elicits CTL Responses towards AL Amyloid-Related Immunoglobulin Light Chain, A. Flies and D.H. Sherr  Diagnostic Accuracy and Prognostic Value of 123I-Labeled Serum Amyloid P Component Body Retention in Patients with Amyloidosis, B.P.C. Hazenberg, M.N. Lub-de Hooge, E. Vellenga, E.B. Haagsma, M.D. Posthumus, and P.L. Jager  A Proteomic Approach to the Study of Systemic Amyloidoses, F. Lavatelli, D.H. Perlman, B. Spencer, T. Prokaeva, M.E. McComb, R. Theberge, L.H. Connors, V. Bellotti, D.C. Seldin, G. Merlini, M. Skinner, and C.E. Costello  Definitive Identification of Amyloid Deposits by Mass Spectrometry, C.L. Murphy, S. Wang, T.K. Williams, D.T. Weiss, and A. Solomon  Tissue Detection of Amyloid by an Amyloid \"Chip\"?, M.M. Picken, B.P.C. Hazenberg, and L. Lomas  Detection and Characterization of Immunoglobulin Light Chain Post-Translational Modifications Using LC/MS-MS/MS, R. Theberge, Y. Jiang, M.E. McComb, T. Prokaeva, L.H. Connors, M. Skinner, D.C. Seldin, and C.E. Costello  The Inhibitory Fc?-Receptor IIB (CD32B) Is Highly Expressed on Clonal Plasma Cells from Patients with Systemic Light-Chain (AL) Amyloidosis and Provides a Target for Monoclonal Antibody Therapy, P. Zhou, A.B. Olshen, E. Bonvini, S. Koenig, M. Fleisher, J. Young, A. Boruchov, and R.L. Comenzo   CLINICAL SESSIONS DIAGNOSTIC INTERACTIVE SESSION:  Report, M.M. Picken, B.P.C. Hazenberg, and L. Obici  CLINICAL INTERACTIVE SESSION:  Report, V. Sanchorawala, G. Palladini, and A. Dispenzieri  CLINICAL TRIAL REPORTS: Clinical Trial for TTR Amyloidosis Using Diflunisal, J.L. Berk, A.B. Bisbee, J.W. Kelly, P.J. Dyck, R.H. Falk, Y. Ando, T. Coelho, S. Ikeda, G. Merlini, O.B. Suhr, M. Skinner, and the Diflunisal Investigators Consortium  Early Harvest Followed by Melphalan-Dexamethasone and Second-Line Autologous Stem Cell Transplantation in AL, P. Russo, G. Palladini, V. Perfetti, F. Lavatelli, M. Nuvolone, L. Obici, and G. Merlini  Treatment of AL Amyloidosis with Tandem Cycles of High Dose Melphalan and Autologous Stem Cell Transplantation:  Final Analysis of a Prospective Trial , V. Sanchorawala, D.G. Wright, K. Quillen, K.T. Finn, L.M. Dember, J.L. Berk, G. Doros, C. Fisher, M. Skinner, and D.C. Seldin