Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation

Front Matter....Pages I-VIII
Why a Workshop on Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation ?....Pages 1-8
Using Embryonal Stem Cells to Introduce Mutations into the Mouse Germ Line....Pages 9-15
New Strategies in Developmental Biology: In vivo Mutagenesis as a Tool to Dissect Mammalian Development....Pages 17-32
Visualization by nlsLacZ of Gene Activity During Mouse Embryogenesis....Pages 33-45
The Albino Perinatal Lethal Mutation: Identification of Affected mRNAs and Mapping of the Locus by Pulsed-Field Gel Electrophoresis....Pages 47-62
Mutations in Transgenic Mice....Pages 63-67
Effects of Provirus Insertion on Expression of α1(I) Collagen Gene in Mov13 Mice....Pages 69-76
Cellular Target Sequences for Retrovirus Integration....Pages 77-93
Identification of Retroviral Sequences Involved in the Inactivation of the Viral Genome in Embryonal Carcinoma Cells....Pages 95-111
Strand Switching During Retroviral Reverse Transcription....Pages 113-121
Do Retroviruses Contribute to the Genesis of Intron-Less Pseudogenes?....Pages 123-131
Biological Activities of Mouse Retrotransposons MURRS/LTR-IS....Pages 133-139
Retroviral Receptors and Interference on Human Cells....Pages 141-152
Cell Targeting by Recombinant Retroviruses Using Bi-Specific Antibody Complexes....Pages 153-164
Improvement of Gene Expression and Virus Production in the Use of Retroviral Vectors for Gene Transfer....Pages 165-173
New Retroviral Models for Gene Therapy: Swords into Plowshares....Pages 175-183
Hemopoietic Regulation Assessed in Clonal Culture: A Brief Overview....Pages 185-191
Haemopoietic Cells as Targets for Gene Transfer....Pages 193-199
Human β-Globin Expression in Murine Bone Marrow Transplant Recipients Reconstituted with Retrovirally Transduced Stem Cells....Pages 201-208
Genetic Manipulation of Human Hematopoietic Stem Cells....Pages 209-219
The Role of Cytokines in the Normal and Abnormal Growth of Hemopoietic Cells....Pages 221-227
Tumour Necrosis Factor and Interleukin-6: Structure and Mechanism of Action of the Molecular, Cellular and in Vivo Level....Pages 229-240
Unexpected Biological Effects of the Deregulated IL-2/IL-2 Receptor System on the Lymphocyte Development....Pages 241-254
T Cell Activation Signals and Regulation of Lymphokine Gene by Viral and Cellular Transactivators....Pages 255-273
Lymphoid VDJ Recombinase Activity: Development of a Novel Fluorescence-Based Assay System....Pages 275-286
Meiotic Copy Number Changes at CUP1 r are Mediated by Gene Conversion....Pages 287-295
Epstein-Barr Virus Gene Expression in Normal and Malignant B Cells: Implications for the Immune T Cell Control of EBV Infection....Pages 297-308
Suppression of Cellular Gene Activity in Adenovirus-Transformed Cells....Pages 309-318
Dysregulated Activation of a Haemopoietic Growth Factor Gene Alone is Insufficient to Cause Malignant Haemopoietic Disease in Normal Haemopoietic Cells....Pages 319-329
Mechanisms of IL-3 Regulated Growth and Transformation of Hematopoietic Cells....Pages 331-341
Synergism Between Oncogenes in T-cell Lymphomagenesis....Pages 343-353
The Mouse Jun Family....Pages 355-372
The c-jun Gene and its Role in Signal Transduction....Pages 373-383
Two Nuclear Oncogene Products Cooperate in the Formation of the Transcription Factor Ap-1....Pages 385-397
p53: Onco - or Anti-Onco - Gene? A Critical Review....Pages 399-407
Inactivation of the Cellular P53 Gene in Friend Virus-Transformed Erythroleukemia Cell Lines....Pages 409-417
Analysis of Transcriptional Regulatory Regions of The Human p53 Gene in Human Cells Using An EBV-Derived Shuttle Vector....Pages 419-436
SV40 DNA Replication In Vitro....Pages 437-448
Back Matter....Pages 449-480