Tumor Models in Cancer Research

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Perspective on the History of Tumor Models....Pages 3-19
Front Matter....Pages 21-21
Murine L1210 and P388 Leukemias....Pages 23-40
Transplantable Syngeneic Rodent Tumors....Pages 41-71
B16 Murine Melanoma....Pages 73-89
Front Matter....Pages 91-91
Xenotransplantation of Human Cell Cultures in Nude Mice....Pages 93-97
GFP-Expressing Metastatic-Cancer Mouse Models....Pages 99-112
Human Tumor Xenografts and Explants....Pages 113-137
Front Matter....Pages 139-139
Hamster Oral Cancer Model....Pages 141-171
Mammary Cancer in Rats....Pages 173-181
Carcinogen-Induced Colon-Cancer Models for Chemoprevention and Nutritional Studies....Pages 183-191
Front Matter....Pages 193-193
Cancer Models....Pages 195-222
Cyclin D1 Transgenic Mouse Models....Pages 223-230
Mice Expressing the Human Carcinoembryonic Antigen....Pages 231-246
The p53 -Deficient Mouse as a Cancer Model....Pages 247-261
The Utility of Transgenic Mouse Models for Cancer Prevention Research....Pages 263-274
Front Matter....Pages 275-275
Metastasis Models....Pages 277-291
Models for Evaluation of Targeted Therapies of Metastatic Disease....Pages 293-319
Front Matter....Pages 321-321
Animal Models of Oral Mucositis Induced by Antineoplastic Drugs and Radiation....Pages 323-335
The Intestine as a Model for Studying Stem-Cell Behavior....Pages 337-357
SENCAR Mouse-Skin Tumorigenesis Model....Pages 359-380
Front Matter....Pages 321-321
Murine Models of Bone-Marrow Transplant Conditioning....Pages 381-405
Anesthetic Considerations for the Study of Murine Tumor Models....Pages 407-431
Front Matter....Pages 433-433
Tissue-Isolated Tumors in Mice....Pages 435-451
Human Breast-Cancer Xenografts as Models of the Human Disease....Pages 453-470
Animal Models of Melanoma....Pages 471-492
Experimental Animal Models for Renal Cell Carcinoma....Pages 493-505
Animal Models of Mesothelioma....Pages 507-520
SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development....Pages 521-540
Models for Studying the Action of Topoisomerase-I Targeted Drugs....Pages 541-563
Spontaneous Pet Animal Cancers....Pages 565-589
Front Matter....Pages 591-591
In Vivo Tumor Response End Points....Pages 593-616
Tumor-Cell Survival....Pages 617-631
Apoptosis in Vivo....Pages 633-645
Transparent Window Models and Intravital Microscopy....Pages 647-671
Back Matter....Pages 673-690