Transgenic Mice and Mutants in MHC Research

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Spontaneous Frequency of H-2 Mutations....Pages 3-13
Microgene Conversion in the Evolution of the MHC Class I Multigene Family....Pages 14-25
Random Mutagenesis by Oligonucleotides: A Probe for MHC Structure and Function....Pages 26-32
Altered Recognition of LCMV Antigen Presented on Mutant Class I Molecules....Pages 33-35
Relationship Between Class II Structure and B Cell Signaling....Pages 36-38
Multivalent Requirement for the Stimulation of Alloreactive T Cells: Studies with Engineered Soluble MHC Class I Proteins In Vitro and In Vivo....Pages 39-46
Novel MHC Variants Spliced by Overlap Extension....Pages 47-55
The Functional Significance of Amino Acid Polymorphisms in Class I MHC Molecules....Pages 56-58
Products of Separate Genes Encoded Within Minor Histocompatibility Loci Stimulate Class I and Class II MHC-Restricted T Cells....Pages 59-61
Determination of Distinction Odortypes by Mutation of Class I and Class II MHC Genes....Pages 62-64
Front Matter....Pages 65-65
Analysis of HLA-B27-Specific T-Cell Epitopes with Site-Directed Mutants Mimicking HLA-B27 Polymorphism....Pages 67-76
The Role of Amino Acid Position and Side Chain Structure in Serological and CTL-Defined Epitopes on the HLA-A2.1 Molecule....Pages 77-88
Two Amino Acids on the α Helical Region of the α 1 Domain Form Multiple Epitopes Recognized by HLA-Bw52 Specific Human Cytotoxic T Cell....Pages 89-90
Front Matter....Pages 91-91
Mouse Mammary Tumor Virus-Directed Gene Expression in Transgenic Mice....Pages 93-101
Regulation of Class I MHC Expression: In Vivo Function of Regulatory DNA Sequence Elements in Transgenic Mice....Pages 102-108
Expression of a Non-Classical Class I Gene in Transgenic Mice....Pages 109-113
Regulation of Expression of Human MHC Class I Heavy (HLA-B7) and Light (h β 2 -m) Chain Genes in Transgenic Mice....Pages 114-124
Cloned Trans-Acting Factors that Bind to the Regulatory Elements of the Major Histocompatibility Complex Class I Gene....Pages 125-132
Transcriptional Regulation of MHC Class II Gene Expression: Are MHC Class II Genes Coordinately Regulated?....Pages 133-142
The Effect of Copy Number on mRNA and Cell Surface Expression of an A β k Transgene....Pages 143-154
Front Matter....Pages 91-91
Construction of Retroviral Vectors for the Study of Tissue-Specific Regulation of Human MHC Class II Genes....Pages 155-157
Front Matter....Pages 159-159
Male Sterility in HLA-B27-Transgenic Mice....Pages 161-164
The Lyt-2 Accessory Molecule is Responsible for the Weak Mouse Anti-HLA Xeno-Response....Pages 165-172
Human HLA-B27 Antigen in Transgenic Mice can Function as a Major Histocompatibility Antigen....Pages 173-178
Cytotoxic T Cell Responses Against Human Class I Molecules in Normal and HLA-A2.1 Transgenic Mice....Pages 179-190
Analysis of the HLA-Cw3 Specific CTL Response of HLA-B7 x Human β 2 Microglobulin Transgenic Mice....Pages 191-197
H-2-Restricted Recognition of Xeno-MHC Antigens by Primary Mouse Cytotoxic T Cells is the Exception Rather than the Rule....Pages 198-204
Copy Number and the Presence of Human β 2 -Microglobulin Control Cell Surface Expression of HLA-B27 Antigen in Transgenic Mice with a 25 kb B27 Gene Fragment....Pages 205-213
Expression and Function in a Transgenic Mouse of an H-2K b Variant Gene Obtained by Site-Directed Mutagenesis in a K bm1 Mutant Mouse....Pages 214-216
Front Matter....Pages 217-217
Clonal Anergy in Transgenic Mice with Pancreatic Expression of MHC Class II I-E....Pages 219-228
Role of Ia Antigens in Clonal Deletion of T Cells: Studies with Recombinant and Transgenic Mice....Pages 229-236
Transgenic Mice with MHC Class II Genes: The Use in the Study of Allelic α / β Chain Pairing and the Production of Engineered Mice with Mutant I-A Genes....Pages 237-246
T Cell Recognition of Major Histocompatibility Complex Antigens in HLA Class II Transgenic Mice....Pages 247-256
Front Matter....Pages 257-257
HLA-B27 and Arthritis....Pages 259-267
HLA-B27 Transgenic Mice as Potential Models of Human Disease....Pages 268-275
Mouse Mutants Affecting Growth and Metastasis of a Syngeneic Tumor....Pages 276-281
Transgene Induced MHC Mismatch Results in Rapid Natural Killer Cell Dependent Elimination of Lymphoma Cells....Pages 282-284
Highly Immunogenic Transformed Tumor Clones Expressing Allogeneic Class I Histocompatibility Gene Demonstrate a Specific Immunotherapeutic Affect Against the Parental Tumor....Pages 285-295
Graft Specific MHC Class II Gene Expression During Allograft Response....Pages 296-298
Influence of MHC and Non-MHC Genes on Tumorigenesis and the Use of the Recombinant Congenic Strains as a Novel Tool for the Genetic Analysis of Tumor Susceptibility....Pages 299-308
Back Matter....Pages 309-317