Toxicological profiles - Rdx

TOXICOLOGICAL PROFILE FOR RDX......Page 1
CONTENTS......Page 7
DISCLAIMER......Page 2
UPDATE STATEMENT......Page 3
FOREWORD......Page 4
PEER REVIEW......Page 5
LIST OF FIGURES......Page 10
LIST OF TABLES......Page 11
1.1 WHAT IS RDX?......Page 12
1.5 HOW CAN RDX AFFECT MY HEALTH?......Page 13
1.8 WHERE CAN I GET MORE INFORMATION?......Page 14
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 15
2.2.1.2 Systemic Effects......Page 16
2.2.1.4 Neurological Effects......Page 17
2.2.2.2 Systemic Effects......Page 18
2.2.2.3 Immunological and Lymphoreticular Effects......Page 36
2.2.2.5 Reproductive Effects......Page 37
2.2.2.8 Cancer......Page 38
2.2.3.2 Systemic Effects......Page 39
2.2.3.8 Cancer......Page 43
2.3.3 Metabolism......Page 44
2.4 RELEVANCE TO PUBLIC HEALTH......Page 45
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 52
2.6 INTERACTIONS WITH OTHER CHEMICALS......Page 53
2.8 METHODS FOR REDUCING TOXIC EFFECTS......Page 54
2.9.1 Existing Information on Health Effects of RDX......Page 55
2.9.2 Identification of Data Needs......Page 56
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 60
4.3 USE......Page 64
5.1 OVERVIEW......Page 65
5.3.1 Transport and Partitioning......Page 67
5.3.2.1 Air......Page 68
5.3.2.2 water......Page 69
5.3.2.3 Sediment and Soil......Page 70
5.4.4 Other Environmental Media......Page 71
5.7 ADEQUACY OF THE DATABASE......Page 72
5.7.1 Identification of Data Needs......Page 73
6. ANALYTICAL METHODS......Page 74
6.1 BIOLOGICAL SAMPLES......Page 75
6.2 ENVIRONMENTAL SAMPLES......Page 79
6.3 ADEQUACY OF THE DATABASE......Page 87
7. REGULATIONS AND ADVISORIES......Page 88
8. REFERENCES......Page 96
Bioconcentration Factor (BCF)......Page 108
Lethal Dose(50) (LD50)......Page 109
Reproductive Toxicity......Page 110
User’s Guide......Page 111
Acronyms, Abbreviations, and Symbols......Page 116