Toxicological profiles - Acrolein

TOXICOLOGICAL PROFILE FOR  ACROLEIN......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.2 HOW MIGHT I BE EXPOSED TO ACROLEIN?......Page 10
1.5 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 11
1.6 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO ACROLEIN?......Page 12
2.1 INTRODUCTION......Page 20
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 21
2.2.1.1 Death......Page 22
2.2.1.2 Systemic Effects......Page 36
2.2.1.6 Reproductive Effects......Page 40
2.2.2.2 Systemic Effects......Page 41
2.2.2.4 Neurological Effects......Page 53
2.2.2.8 Cancer......Page 54
2.2.3.3 Immunological Effects......Page 55
2.3.1.1 Inhalation Exposure......Page 56
2.3.3 Metabolism......Page 59
2.3.3.1 Inhalation Exposure......Page 60
2.4 RELEVANCE TO PUBLIC HEALTH......Page 62
2.5.1 Biomarkers Used to Identify or Quantify Exposure to Acrolein......Page 71
2.7 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 72
2.8.1 Existing Information on Health Effects of Acrolein......Page 73
2.8.2 Identification of Data Needs......Page 75
2.8.3 Ongoing Studies......Page 78
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 79
4.3 USE......Page 83
5.1 OVERVIEW......Page 84
5.2.1 Air......Page 87
5.3.1 Transport and Partitioning......Page 90
5.3.2.2 Water......Page 91
5.4.1 Air......Page 92
5.4.4 Other Media......Page 93
5.6 POPULATIONS WITH POTENTIALLY HIGH EXPOSURE......Page 94
5.7.1 Identification of Data Needs......Page 95
6.1 BIOLOGICAL MATERIALS......Page 97
6.2 ENVIRONMENTAL SAMPLES......Page 98
7. REGULATIONS AND ADVISORIES......Page 103
8. REFERENCES......Page 108
Developmental Toxicity......Page 145
Mutagen......Page 146
Teratogen......Page 147
User's Guide......Page 148
Acronyms, Abbreviations, and Symbols......Page 154