Toxicological profiles - 1,1,2-trichloroethane

TOXICOLOGICAL PROFILE FOR 1,1,2-TRICHLOROETHANE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.2 HOW MIGHT I BE EXPOSED TO 1,1,2-TRICHLOROETHANE?......Page 10
1.6 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 11
1.8 WHERE CAN I GET MORE INFORMATION?......Page 12
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 17
2.2.1.1 Death......Page 18
2.2.1.2 Systemic Effects......Page 21
2.2.1.4 Neurological Effects......Page 22
2.2.2.1 Death......Page 23
2.2.2.2 Systemic Effects......Page 30
2.2.2.3 Immunological Effects......Page 33
2.2.2.4 Neurological Effects......Page 34
2.2.2.6 Reproductive Effects......Page 35
2.2.2.8 Cancer......Page 36
2.2.3.2 Systemic Effects......Page 37
2.2.3.4 Neurological Effects......Page 40
2.3 RELEVANCE TO PUBLIC HEALTH......Page 41
2.5 LEVELS IN THE ENVIRONMENT ASSOCIATED WITH LEVELS IN HUMAN TISSUES AND/ OR HEALTH EFFECTS......Page 47
2.6.1.3 Dermal Exposure......Page 48
2.6.3 Metabolism......Page 49
2.6.4.1 Inhalation Exposure......Page 50
2.6.4.2 Oral Exposure......Page 51
2.8 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 52
2.9.1 Existing Information on Health Effects of Trichloroethane......Page 53
2.9.2 Data Needs......Page 54
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 57
4.3 USE......Page 61
5.1 OVERVIEW......Page 62
5.2.1 Air......Page 65
5.2.3 Soil......Page 66
5.3.2.1 Air......Page 67
5.3.2.3 Soil......Page 68
5.4.1 Air......Page 69
5.4.3 Soil......Page 70
5.6 POPULATIONS WITH POTENTIALLY HIGH EXPOSURE......Page 71
5.7.1 Data Needs......Page 72
6.1 BIOLOGICAL MATERIALS......Page 73
6.2 ENVIRONMENTAL SAMPLES......Page 74
6.3.1 Data Needs......Page 78
7. REGULATIONS AND ADVISORIES......Page 79
8. REFERENCES......Page 82
Chronic Exposure......Page 96
Malformations......Page 97
Target Organ Toxicity......Page 98
User s Guide......Page 99
Acronyms, Abbreviations, and Symbols......Page 104
PEER REVIEW......Page 108