The Hypertrophied Heart: Biophysical, biochemical, and morphological aspects of hypertrophy. International Erwin Riesch Symposium,Tübingen, September 26–29, 1976

Front Matter....Pages N3-IV
Preface....Pages 1-1
The instantaneous force-velocity relationship as an index of the contractile state in cardiac muscle....Pages 2-9
The effect of preload and Ca ++ -ions on the time-course of the isometric force and on the force-velocity relation: Is V max dependent on the number of activated cross-bridges?....Pages 10-16
Molecular aspects of muscle contraction and regulation....Pages 17-25
Regulation of actin-myosin interaction....Pages 26-31
Evidence for head-head interactions in myosin from cardiac and skeletal muscles....Pages 32-40
Ca ++ activation of ATPase activity, ATP-P 1 exchange, and tension in briefly glycerinated heart muscle....Pages 41-47
Elementary events in excitation-contraction coupling of the mammalian myocardium....Pages 48-54
The reversal of the calcium pump of cardiac sarcoplasmic reticulum....Pages 55-60
The partitioning of altered mechanics in hypertrophied heart muscle between the sarcoplasmic reticulum and the contractile apparatus by means of myothermal measurements....Pages 61-67
Myocardial function in different models of cardiac hypertrophy. An attempt at correlating mechanical, biochemical, and morphological parameters....Pages 68-75
Analytical approach to mathematical modelling of the isometric contraction of the hypertrophied myocardium....Pages 76-79
Cardiac function in the chronically volume-overloaded canine heart....Pages 80-85
Dynamics of the hypertrophied left ventricle in the rat. Effects of physical training and chronic pressure load....Pages 86-91
Effects of hypertrophy on contractile function in man....Pages 92-97
Dynamic geometry of the left ventricle in hypertrophy studied by quantitative angiocardiography....Pages 98-105
Cellular changes in mechanically overloaded heart....Pages 106-110
Myocardial hypertrophy Light microscopic findings on the myocardium Blood supply Ventricular dilatation and heart failure....Pages 111-116
Time course of electron microscopic alterations in the hypertrophied myocardium of Goldblatt rats....Pages 117-121
Experimental studies on cardiac muscle cell adaptation to insult....Pages 122-129
Hypertrophy due to chronic volume overloading in the dog heart. A morphometric study....Pages 130-135
The common mechanism of the heart’s adaptation and deadaptation: hypertrophy and atrophy of the heart muscle....Pages 136-142
Metabolism of myofibrillar proteins in the normal and hypertrophic heart....Pages 143-148
Changes of myocardial adenine nucleotide and protein synthesis during development of cardiac hypertrophy....Pages 149-154
Transformation of morphological, functional and metabolic properties of fast-twitch muscle as induced by long-term electrical stimulation....Pages 155-161
Cardiac myosin Phylogenic and pathological changes....Pages 162-168
Characteristics of the hypertrophied left ventricular myocardium in Goldblatt rats....Pages 169-175
The role of Ca ++ ions in the hypertrophied myocardium....Pages 176-181
The intracellular pH and the buffer capacity of the heart....Pages 182-186
Restriction of β -adrenergic responsiveness in hypertrophied ventricular myocardium of rats....Pages 187-193
Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy....Pages 194-200
Myocardial oxygen consumption and substrate uptake in man during physiological and pathological volume load....Pages 201-206
Influences on the efficiency of cardiac work....Pages 207-213
Left ventricular systolic wall stress as a primary determinant of myocardial oxygen consumption: Comparative studies in patients with normal left ventricular function, with pressure and volume overload and with coronary heart disease....Pages 214-221
Back Matter....Pages 222-222