Stimuli-responsive drug delivery systems

Content: Cover
 Stimuli-responsive Drug Delivery Systems
 Preface
 Dedication
 Contents
 Chapter 1 --
Fundamentals of Stimuli-responsive Drug and Gene Delivery Systems
 1.1 Introduction
 1.2 pH-Sensitive DDS
 1.3 Redox Potential-sensitive DDS
 1.4 Enzyme-sensitive DDS
 1.5 Thermo-sensitive DDS
 1.6 Magnetically-sensitive DDS
 1.7 Ultrasound-sensitive DDS
 1.8 Light-sensitive DDS
 1.9 Stimuli-sensitive DDS for Combination Therapy: Case of Cancer
 1.10 Concluding Remarks
 References
 Chapter 2 --
Materials and Chemistry of Stimuli-responsive Drug Delivery Systems
 2.1 Introduction
 2.2 Physical Stimuli 2.2.1 Thermoresponsive Materials2.2.2 Photoresponsive Materials
 2.2.2.1 Photoisomerizable Groups
 2.2.2.2 Photo-cleavable Groups
 2.2.3 Magnetically Responsive Materials
 2.3 Chemical Stimuli
 2.3.1 pH Responsive Materials
 2.3.2 Thiol-responsive Materials
 2.4 Biological/Biochemical Stimuli
 2.5 Summary
 References
 Chapter 3 --
pH-responsive Drug Delivery Systems
 3.1 Introduction
 3.1.1 pH Environment in Gastrointestinal Organs
 3.1.2 Acidic pH Environment in Pathological Tissues
 3.1.3 Acidic Subcellular Organelles
 3.2 Classification of pH-responsive Materials 3.2.1 Polymers with Ionizable Functional Groups3.2.1.1 pH-responsive Acidic Polymers
 3.2.1.2 pH-responsive Basic Polymers
 3.2.1.3 pH-responsive Natural Polymers
 3.2.2 Acid-labile pH-sensitive Nanocarriers
 3.2.3 pH-responsive Inorganic Nanoscale Materials
 3.3 Release Mechanism of pH-responsive DDS
 3.3.1 Hydrophobic-Hydrophilic Transition Induced Disassembly
 3.3.2 Cleavage of Acid-labile Linkers for Drug Release
 3.3.3 Gel Swelling
 3.3.4 Cap/Coating Removal
 3.3.5 Gas Generation
 3.4 pH-responsive DDS for Targeted Delivery
 3.4.1 PEG Shedding
 3.4.2 Ligand Shielding/Deshielding 3.4.3 Ligand Pop-up Targeting3.4.4 Charge Reversal
 3.4.5 Size Change
 3.4.6 Membrane Fusion by pH-sensitive Peptides
 3.4.6.1 pH-(Low) Insertion Peptide (pHLIP)
 3.4.6.2 pH-activatable Cell-penetrating Peptides CPPs
 3.5 pH-responsive DDS for Intracellular Delivery
 3.6 Conclusions
 References
 Chapter 4 --
Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract
 4.1 Introduction
 4.2 Gastrointestinal Tract
 4.2.1 Constitution of the Gastrointestinal Tract
 4.2.2 Differences Between Normal and Diseased Tissues
 4.2.3 Inflammatory Bowel Disease 4.2.4 Gastric and Colorectal Cancer4.3 Thermo-responsive Materials and Nanocarrier Systems
 4.3.1 Thermo-responsive Polymeric Nanoparticles
 4.3.2 Thermo-responsive Liposomes
 4.3.3 Thermo-responsive Micelles
 4.4 Conclusions and Future Perspectives
 Acknowledgements
 References
 Chapter 5 --
Redox-responsive Drug Delivery Systems
 5.1 Redox-responsive Drug Delivery Systems
 5.1.1 Redox Profile of the Tumor Microenvironment and the Cancer Cell
 5.1.1.1 Reactive Oxygen Species
 5.1.1.2 Glutathione
 5.1.1.3 Redox Potential in Cancer Cell
 5.1.2 Reduction (Glutathione)-responsive Systems