Science of Ashwagandha

Front Matter ....Pages i-xx
Front Matter ....Pages 1-1
 Phytochemical Genomics of Ashwagandha  (Neelam S. Sangwan, Sandhya Tripathi, Yashdeep Srivastava, Bhawana Mishra, Neha Pandey)....Pages 3-36
 Phytopharmacology of Ashwagandha as an Anti-Diabetic Herb  (Vikas Kumar, Amitabha Dey, Shyam Sunder Chatterjee)....Pages 37-68
 Allium cepa Root Chromosomal Aberration Assay: An Application in Assessing Anti-genotoxic Potential of Ashwagandha  (Rajneet Kour Soodan, Ashita Sharma, Mandeep Kaur, Jatinder Kaur Katnoria, Avinash Kaur Nagpal)....Pages 69-79
 Withania somnifera: From Traditional Use to Evidence Based Medicinal Prominence  (Sheikh Rayees, Fayaz Malik)....Pages 81-103
 Withanolides: A Prospective Drug for Infectious and Tropical Diseases  (Radheshyam Maurya)....Pages 105-120
 Withania somnifera Extract/Withaferin A as a Prospective Anti-pigmenting Agent  (Genji Imokawa)....Pages 121-146
Front Matter ....Pages 147-147
 Ashwagandha Bioactives for Cancer Treatment: Experimental Evidence and Their Mechanism(s) of Action  (Renu Wadhwa, Sukant Garg, Ashish Kaul, Sunil C. Kaul)....Pages 149-174
 Scientific Evidence for Anticancer Effects of Withania somnifera and Its Primary Bioactive Component Withaferin A  (Anuradha Sehrawat, Suman K. Samanta, Su-Hyeong Kim, Eun-Ryeong Hahm, Shivendra V. Singh)....Pages 175-196
 Withaferin-A as a Potential Candidate for Cancer Therapy: Experimental Evidence of Its Effects on Telomerase Plus and Minus Cancer Cells  (Zeenia Kaul, Yue Yu, Sunil C. Kaul, Renu Wadhwa)....Pages 197-212
 Withania somnifera Has Potential to Treat Cancer  (Babli Halder, Suman S. Thakur)....Pages 213-226
 The Effects of Withaferin A on Normal and Malignant Immune Cells  (Sara S. Alhakeem, Mary K. McKenna, Karine Z. Oben, Beth W. Gachuki, Sunil K. Noothi, Natarajan Muthusamy et al.)....Pages 227-242
 Ashwagandha for Cancer Metastasis: Bioactives and Basics of Their Function  (Sunil C. Kaul, Priyanshu Bhargava, Renu Wadhwa)....Pages 243-262
 Computational Methods to Understand the Anticancer Mechanism of Withanolides  (Shashank P. Katiyar, Vidhi Malik, Anjani Kumari, Durai Sundar)....Pages 263-280
Front Matter ....Pages 281-281
 Ashwagandha for Brain Health: Experimental Evidence for Its Neuroregenerative Activities  (Renu Wadhwa, Rajkumar S. Kalra, Anupama Chaudhary, Sunil C. Kaul)....Pages 283-304
 Cellular and Molecular Targets Underpinning Memory Enhancement by Ashwagandha  (Arpita Konar, Mahendra K. Thakur)....Pages 305-318
 Using Human Neural Stem Cells as a Model to Understand the “Science of Ashwagandha”  (Manju Tewari, Hriday S. Pandey, Pankaj Seth)....Pages 319-344
 The Potential Utility of Ashwagandha for Improving Cognitive Dysfunction in Persons with Bipolar or Other Neurocognitive Disorders  (K. N. Roy Chengappa, Jessica M. Gannon, Luna Acharya, Abhishek Rai)....Pages 345-371
 Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions  (Rajat Sandhir, Abhilasha Sood)....Pages 373-387
 Potential Therapeutic Use of Withania somnifera for Treatment of Amyotrophic Lateral Sclerosis  (Kallol Dutta, Vivek Swarup, Jean-Pierre Julien)....Pages 389-415
 Neuromodulatory Role of Withania somnifera  (Gurcharan Kaur, Taranjeet Kaur, Muskan Gupta, Shaffi Manchanda)....Pages 417-436
 Therapeutic Effects of Ashwagandha in Brain Aging and Clock Dysfunction  (Anita Jagota, K. Kowshik)....Pages 437-456
Front Matter ....Pages 457-457
 Biotechnological Approaches in Propagation and Improvement of Withania somnifera (L.) Dunal  (Kulwinder Kaur, Pritika Singh, Rupam Guleri, Baldev Singh, Kuldeep Kaur, Varinder Singh et al.)....Pages 459-478
 Plant Tissue Culture Based Strategies for Production of Withanolides  (Deepika Soni, Preeti Rana, Sukriti Goyal, Aditi Singh, Salma Jamal, Abhinav Grover)....Pages 479-493
 Establishment of Hydroponic Cultivation of Ashwagandha for Active Ingredient Enriched Leaves  (Sunil C. Kaul, Sukant Garg, Kazuya Tamura, Teruo Wada, Zeenia Kaul, Renu Wadhwa)....Pages 495-508