S-Heterocycles: Synthesis and Biological Evaluation

Cover
Half Title
S-Heterocycles: Synthesis and Biological Evaluation
Copyright
Foreword
Preface
Contents
Editor and Contributors
1. Synthesis and Biological Evaluation of Thiophene and Its Derivatives
	1.1 Introduction
	1.2 General Approaches to Thiophene Ring Synthesis
	1.3 Biological Activities of Thiopene Molecules
		1.3.1 Anti-inflammatory Activity
		1.3.2 Anticancer Activity
		1.3.3 Antioxidant Activity
		1.3.4 Antimicrobial Activity
	1.4 Conclusion
	References
2. Synthesis and Biological Evaluation of 4-Thiazolidinone Scaffold: A Versatile Chemistry and Diverse Biological Applications in the Drug Discovery and Development
	2.1 Introduction
	2.2 Synthesis of Thiazolidinone
	2.3 Pharmaceutical Profile of Thiazolidinones
		2.3.1 Antimicrobial Activity
		2.3.2 Anticancer Activity
		2.3.3 Antimalarial Activity
		2.3.4 Anti-inflammatory Activity
		2.3.5 Anti-HIV Activity
		2.3.6 Antitubercular Activity
		2.3.7 Antidiabetic Activity
		2.3.8 Antioxidants Activity
		2.3.9 Antiparasitic Activity
		2.3.10 Miscellaneous Activity
	2.4 Conclusion
	References
3. Synthesis and Biological Evaluation of Thiazoline, Thiophene and Thiazole Scaffolds
	3.1 Introduction
	3.2 Thiazoline Derivatives
	3.3 Thiophene
	3.4 Thiazole Derivatives
	3.5 Biological Claim of Thiazole Scoffed
	3.6 Anticancer Activity
	3.7 Anticonvulsant Activity
	3.8 Antitubercular Activity
	3.9 Anti-inflammatory Activity
	3.10 Conclusion
	References
4. Synthesis and Biological Evaluation of Thiirane and Its Derivatives
	4.1 Introduction
	4.2 Synthesis of Thiirane
		4.2.1 Derivatives of Thiirane
	4.3 Conclusion
	References
5. Synthesis and Biological Evaluation of 1,3,5-Dithiazinanes: Synthesis, Stereochemistry and Applications
	5.1 Introduction
	5.2 Multicomponent Cyclothiomethylation of Amines as a Methodology for the Synthesis of 1,3,5-Dithiazinanes
	5.3 Recyclization of 1,3,5-Hexahydrotriazines in the Synthesis of 1,3,5-Dithiazinanes
	5.4 1,3,5-Dithiazinanes as S,N-Containing Polydentate Ligands
		5.4.1 Complexation with Lewis Acids
		5.4.2 Complexation with [H2Os3(CO)10]
		5.4.3 Complexes with Alkyl Halides
	5.5 Synthesis of Organoelement Derivatives of 1,3,5-Dithiazinanes
	5.6 C2 Functionalization of 1,3,5-Dithiazinanes
	5.7 Original Approaches to the Synthesis of 1,3,5-Dithiazinanes
	5.8 Practical Application of 1,3,5-Dithiazinanes
	5.9 Conclusion
	References
6. Synthesis and Biological Evaluation of Benzothiazepine, Benzothiazole, and Benzothiophene Derivatives
	6.1 Introduction
	6.2 Benzothiazepines
		6.2.1 Different Synthetic Approach for Benzothiazepines
	6.3 Benzothiazole
		6.3.1 Different Synthetic Approach for Benzothiazole Derivatives
	6.4 Benzothiophene
		6.4.1 Different Synthetic Approach for Benzothiophene Derivatives
	6.5 Conclusion
	References
7. Synthesis and Biological Evaluation of Some Fused Pyrrolothiazoles, Pyrazolothiazoles, and Imidazothiazoles
	7.1 Introduction
	7.2 Synthesis of Pyrrolothiazole
	7.3 Synthesis of Pyrazolothiazoles
		7.3.1 Synthesis of Pyrazolo[3,4-d]thiazoles
		7.3.2 Synthesis of Pyrazolo[4,3-d]thiazoles
		7.3.3 Synthesis of Pyrazolo[5,1-d]thiazoles
		7.3.4 Synthesis of Imidazothiazole
		7.3.5 Conclusion
	References
8. Synthesis and Biological Evaluation of Some Dithiazines
	8.1 Introduction
	8.2 Synthesis and Biological Activity
	8.3 Conclusion
	References
9. Synthesis and Biological Evaluation of Some Sulfur-Containing Spiro Compounds
	9.1 Introduction
	9.2 Construction of Five-Member Sulfur-Containing Rings
		9.2.1 Construction of Thiophene Ring Annulated Spiro Compounds
		9.2.2 Construction of Dithiolane Ring Annulated Spiro Compounds
	9.3 Construction of Six-Member Sulfur-Containing Rings
		9.3.1 Construction of Thiopyran Ring Annulated Spiro Compounds
		9.3.2 Construction of Dithiine Ring Annulated Spiro Compounds
	9.4 Conclusion
	References
10. Synthesis and Biological Evaluation of Some Polycyclic Aromatic Hydrocarbons
	10.1 Benzothiophene
		10.1.1 Introduction
	10.2 Synthesis
		10.2.1 Biological Activity
		10.2.2 Conclusion
	10.3 Dibenzothiophene
		10.3.1 Introduction
		10.3.2 Synthesis
		10.3.3 C-X Cleavage for Dibenzothiophene Synthesis
		10.3.4 Conclusion
	10.4 Thienothiophene
		10.4.1 Introduction
		10.4.2 Synthesis
		10.4.3 Biological Activity
		10.4.4 Conclusion
	References
11. Synthesis and Biological Evaluation of Some Thietane Derivatives
	11.1 General Introduction of Thietanes and Its Derivatives
	11.2 Synthetic Routes for Thietanes and Its Derivatives
	11.3 Biological Potency of Thietanes and Its Derivatives
		11.3.1 Anti-depressant and Anti-hypotensive Activity
		11.3.2 Anti-cancer Activity
		11.3.3 Anti-viral Activity
		11.3.4 Anti-bacterial and Anti-infection Activity
		11.3.5 Anti-tuberculosis Activity
		11.3.6 Anti-inflammation Activity
		11.3.7 Anti-diabetic Activity
		11.3.8 Anti-platelet and Anti-coagulant Activity
	11.4 Conclusion
	References
12. Synthesis and Biological Evaluation of Fused Thiazolotriazole and Imidazothiadiazole Scaffolds
	12.1 Introduction
	12.2 Thiazolotriazoles
		12.2.1 Introduction
		12.2.2 Synthesis of Thiazolotriazoles
		12.2.3 Biological Activity
	12.3 Imidazothiadiazole
		12.3.1 Introduction
		12.3.2 Synthesis of Imidazothiadiazole
		12.3.3 Biological Activity of Imidazo[2,1-b][1,3,4]Thiadiazole
	12.4 Miscellaneous Reaction
		12.4.1 Pyrrolo[2,1-b]thiazole
		12.4.2 Imidazotriazoles
	12.5 Conclusion
	References