Reversible Protein Acetylation

REVERSIBLE PROTEIN ACETYLATION......Page 3
Contents......Page 7
Participants......Page 10
Chair’s introduction......Page 13
Beyond the double helix: writing and reading the histone code......Page 15
Discussion......Page 29
The indexing potential of histone lysine methylation......Page 34
Discussion......Page 49
A model for step-wise assembly of heterochromatin in yeast......Page 60
Discussion......Page 68
H2B ubiquitylation and de-ubiquitylation in gene activation......Page 75
Discussion......Page 85
Structural and chemical basis of histone acetylation......Page 90
Discussion......Page 110
Phosphorylation and acetylation of histone H3 at inducible genes: two controversies revisited......Page 114
Discussion......Page 123
HDAC7 regulates apoptosis in developing thymocytes......Page 127
Discussion......Page 141
Dual roles of histone deacetylases in the control of cardiac growth......Page 144
Discussion......Page 153
Chromatin modifications as clues to the regulation of antigen receptor assembly......Page 158
Discussion......Page 170
General discussion I Histone modification in X inactivation......Page 175
The HDAC complex and cytoskeleton......Page 182
Discussion......Page 190
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation......Page 194
Discussion......Page 205
Dynamics of the p53 acetylation pathway......Page 209
Discussion......Page 217
Regulation of NF-kB action by reversible acetylation......Page 220
Discussion......Page 230
General discussion II p300 and DNA repair......Page 235
Reversal of gene silencing as a therapeutic target for cancer—roles for DNA methylation and its interdigitation with chromatin......Page 238
Discussion......Page 246
Transcription regulation by histone deacetylases......Page 250
Discussion......Page 257
Molecular and cellular basis for the anti-proliferative effects of the HDAC inhibitor LAQ824......Page 261
Discussion......Page 278
Histone deacetylase inhibitors: development as cancer therapy......Page 281
Discussion......Page 293
General discussion III PML-RARa hypermethylation in leukaemia......Page 297
Index of contributors......Page 301
Subject index......Page 303