Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Immunochemistry of Hybridomas....Pages 3-21
Characterization and Selection Criteria of Monoclonal Antibodies for Tumor Imaging Studies....Pages 23-38
Tumor Markers and Their Relevance in the Design of Radioimmunoimaging Experiments....Pages 39-50
Selection of Monoclonal Antibodies with Optimal Biological Functions for Clinical Application....Pages 51-54
Selection and Utilization of Monoclonal Antibody Defined Melanoma Associated Antigens for Immunoscintigraphy in Patients with Melanoma....Pages 55-73
Development and Characterization of Human Monoclonal Antibodies and Their Application in the Radioimmunodetection of Colon Carcinoma....Pages 75-94
Progress in Diagnostic Immunoscintigraphy and First Approach to Radioimmunotherapy of Colon Carcinoma....Pages 95-110
The Design of a Radiolabeled Monoclonal Antibody for Radioimmunodiagnosis and Radioimmunotherapy....Pages 111-122
Immunohistochemistry and Correlation with Plasma Levels of CA 19-9 and CEA in Gastrointestinal Tumors....Pages 123-128
Optimization of Mouse IgG Fragmentation Technique in the Selection of Monoclonal Antibodies for Myocardial Infarct Imaging....Pages 129-137
Sensitivity and Efficacy Indices for Oncologic Data Reporting....Pages 139-145
Front Matter....Pages 147-147
Production and Use of Prospective Radionuclides for Radioimmunotherapy....Pages 149-163
Criteria for the Selection of Nuclides for Radioimmunotherapy....Pages 165-176
Experience with Iodine-123 Labeled Antibodies....Pages 177-191
Front Matter....Pages 193-193
Radiohalogenation of Antibodies: Chemical Aspects....Pages 195-213
Radiohalogenation of Monoclonal Antibodies: Experiences with Radioiodination of Monoclonal Antibodies for Radioimmunotherapy....Pages 215-227
Use of Bifunctional Chelating Agents for Radiolabeling Antibodies....Pages 229-238
Monoclonal Antibody Labeling with Indium-111 and Gadolinium via DTPA Chelation on Selective and Nonselective Sites of the Antibody....Pages 239-251
Important Chemical Variables for Labeling Antibodies with Indium-111 and Technetium-99m....Pages 253-260
Potential Labeling of Monoclonal Antibodies with Positron Emitters....Pages 261-267
Front Matter....Pages 269-292
Quantitative Pharmacokinetics of Radiolabeled Monoclonal Antibodies for Imaging and Therapy in Patients....Pages 293-310
Kinetic Analysis with Probability Mapping in Radioimmunoscintigraphy....Pages 311-322
Biokinetic Studies and Scintigraphic Imaging of Human Carcinoma Xenografts with Radiolabeled Monoclonal Antibodies....Pages 323-341
Use of an Animal Model System for Evaluating Labeled Monoclonal Antibodies....Pages 343-361
Antibody-Hapten Complexes for Imaging....Pages 363-375
Antibody — Carboxypeptidase G2 Conjugates as Potential Tumour Imaging Agents....Pages 377-383
In Vivo Kinetics of 131 I-Monoclonal Antibodies [anti-CEA and 19-9, F(ab′) 2 ] in Humans....Pages 385-390
Front Matter....Pages 391-391
The National Institutes of Health Experience with Radiolabeled Monoclonal Antibodies: Lymphoma, Melanoma, and Colon Cancer....Pages 393-407
Adjuvant Radioimmunotherapy for Micrometastases: A Strategy for Cancer Cure....Pages 409-429
Quantitative Imaging and Internal Radiation Dosimetry in the Therapeutic Use of Labeled Monoclonal Antibodies....Pages 431-443
The Distribution of Halogenated (At-211 or I-125) Tumor Specific Antibody in Tumor Bearing and Control Mice....Pages 445-450
Front Matter....Pages 463-463
State-of-the-Art and Performance Testing of Instrumentation for the Scintigraphic Detection of Tumors with Labeled Monoclonal Antibodies....Pages 465-493
Theoretical Limitations of Tumor Imaging....Pages 495-512
Image Subtraction Techniques in Immunoscintigraphy....Pages 513-540
Digital Superimposition of Single Photon Emission Computerized Tomography (SPECT) and CT Images for Immunoscintigraphy....Pages 541-550
Radioimmunoscintigraphy — SPECT with I-131 — MAbs; Comparison with TCT in the Follow-up of Colorectal Cancer....Pages 551-555
Comparative Prospective Detection of Recurrences of Carcinomas with SPECT Imaging Using Radiolabeled Monoclonal Antibodies, Ultrasonography and Computed Tomography....Pages 557-569
NMR Enhancement with Gd Labeled Antibodies....Pages 571-579
Front Matter....Pages 581-581
Preclinical and Clinical Studies with Indium-111 anti-CEA Antibodies and Fragments....Pages 583-610
Clinical Experience in Cancer Diagnosis with Radiolabeled Monoclonal Antibodies in 200 Patients and Initial Attempts at Radioimmunotherapy....Pages 613-651
Front Matter....Pages 581-581
Tumor Radioimmunodetection by anti-Melanoma and anti-CEA Monoclonal Antibodies: Pilot and Prospective Studies....Pages 653-681
Tumor Immunoscintigraphy: Multicenter Clinical Trials of the Italian National Research Council (CNR)....Pages 683-694
Interstitial and Intravenous Application of Monoclonal Antibody F(ab’) 2 Fragments in the Detection of Lymph Node Metastases: Benefits and Problems with Both Routes of Administration....Pages 695-699
Radioimaging of Melanoma and CEA Secreting Tumours by Monoclonal Antibodies Performed by Different Routes of Administration....Pages 701-714
A Monoclonal Antibody (Po66-2) Reactive with Human Lung Squamous Cell Carcinoma — Cell Reactivity In Vitro and Preliminary Scintigraphic Trials....Pages 715-722
Monoclonal Antibodies Against Human Osteosarcoma: Preliminary Studies....Pages 723-728
Front Matter....Pages 737-737
Radioimmunotherapy of Cancer: Historical Perspectives and Prospects for the Future....Pages 739-768
Recent Perspectives on the Use of Radiolabeled Monoclonal Antibodies for Immunotherapy....Pages 769-779
Intraperitoneal Therapy of Ovarian Cancer with Radiolabeled Monoclonal Antibodies....Pages 781-791
Front Matter....Pages 793-793
Radioactive Monoclonal Antibodies Against Cell Surface Antigens for Labeling Leukocyte Subpopulations....Pages 795-805
Monoclonal Antibody Against Human Fibrin for Imaging Thrombi....Pages 807-815
Radiolabeled Antiplatelet Monoclonal Antibodies for the Scintigraphic Localization of In-vivo Thrombi and Vascular Lesions....Pages 817-830
Potential of Radiolabeled Antiplatelet Antibodies in the Detection of Vascular Thrombi....Pages 831-845
Back Matter....Pages 847-876