Progress in Polyamine Research: Novel Biochemical, Pharmacological, and Clinical Aspects

Front Matter....Pages i-xiv
Front Matter....Pages xv-xv
Androgen Regulation of Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase Gene Expression....Pages 1-11
Regulation of Polyamine Biosynthesis in Escherichia Coli by the Acidic Antizyme and the Ribosomal Proteins S20 and L34....Pages 13-24
Studies on Ornithine Decarboxylase Antizyme....Pages 25-35
Ornithine Decarboxylase Antizyme in Mammalian Tissues....Pages 37-43
Phosphorylation by Casein Kinase-2 and Reversible Alteration of Thiol Groups: Mechanisms of Control of Ornithine Decarboxylase?....Pages 45-53
Modifications of Ornithine Decarboxylase Induced by Phosphatases....Pages 55-70
Front Matter....Pages 71-71
 S -Adenosylmethionine Decarboxylase from Escherichia Coli and from Saccharomyces Cerevisiae : Cloning and Overexpression of the Genes....Pages 73-79
Structural and Mechanistic Properties of E. Coli Adenosylmethionine Decarboxylase....Pages 81-89
S-Adenosylmethionine Decarboxylase from the Thermophilic Archaebacterium Sulfolobus Solfataricus ....Pages 91-100
Properties of Human and Rodent S-Adenosylmethionine Decarboxylase....Pages 101-109
Aminopropyltransferases: Mechanistic Studies and the Synthesis of Specific Inhibitors....Pages 111-115
Approaching the Structures of Mammalian Propylamine Transferases and their Genes....Pages 117-126
Potential Roles of Polyamine Interconversion in the Mammalian Organism....Pages 127-145
The Biological Functions of Amine Oxidases and their Reaction Products: An Overview....Pages 147-161
Front Matter....Pages 163-163
Human 5′-Deoxy-5′-Methylthioadenosine Phosphorylase: Kinetic Studies and Catalytic Mechanism....Pages 165-177
Methylthioadenosine (MeSAdo) Phosphorylase Deficiency in Malignancy....Pages 179-185
Physico-Chemical and Immunological Properties of Bovine Liver 5′-Deoxy-5′-Methylthioadenosine Phosphorylase....Pages 187-197
Exploitation of Methylthioribose Kinase in the Development of Antiprotozoal Drugs....Pages 199-210
MTA Phosphorylase in Protozoa: A Potential Target for Chemotherapeutic Attack....Pages 211-218
Characterization and Biogenesis of 5′-Methylthioxylofuranosyl Adenine, a New Natural Analog of 5′-Methylthioadenosine....Pages 219-228
Front Matter....Pages 163-163
Studies on Human Serum 5′ -Deoxy-5′ -Methylthioadenosine Phosphorylase: Molecular Properties and Clinical Perspectives....Pages 229-238
Front Matter....Pages 239-239
Growth-Regulation of the Cellular Levels and Expression of the mRNA Molecules Coding for Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase....Pages 241-252
Structure, Amplification and Methylation of Ornithine Decarboxylase Genes in Human Malignant Cells....Pages 253-260
Regulation of Polyamine Synthesis in Mammalian Cells....Pages 261-271
Mechanisms Involved in Ornithine Decarboxylase Induction by 12-O-Tetradecanoylphorbol-13-Acetate, a Potent Mouse Skin Tumor Promoter and an Activator of Protein Kinase C....Pages 273-290
Polyamines, DNA Methylation and Cell Differentiation....Pages 291-299
Two Phases of Ornithine Decarboxylase Activation During Lymphocyte Mitogenesis....Pages 301-313
Regulation of Protein Synthesis by Polyamines....Pages 315-330
Polyamine Recycling Enzymes in Human Cancer Cells....Pages 331-344
Estrogenic Control of Spermidine/Spermine N 1 -Acetyltransferase Activity in Rat Uterus....Pages 345-351
Erythrocyte Polyamines: Their Diagnostic and Therapeutic Importance in Human Neuro-Oncology....Pages 353-363
Abnormalities of Polyamine Biosynthesis in Spinal Cord of Totally Gastrectomized Rats....Pages 365-378
Ornithine Decarboxylase and Polyamine Biosynthesis in Pancreatic Adaptation....Pages 379-388
Front Matter....Pages 389-389
Transglutaminases and Their Regulation: Implications for Polyamine Metabolism....Pages 391-401
Purification and Structural Characterization of In Vitro Synthesized (γ-Glutamyl) Spermidine Conjugates of a Major Protein Secreted from the Rat Seminal Vesicles....Pages 403-409
Covalent Polyamine-Protein Conjugates: Analysis and Distribution....Pages 411-422
Spermidine in Mammalian Lymphocytes and Sea Urchin Embryos: Uptake and Labeling of Macromolecules....Pages 423-434
Biosynthesis of Hypusine in eIF-4D Precursors....Pages 435-447
Hypusine Biosynthesis in Protein and its Biological Consequences....Pages 449-458
Deoxyhypusine Hydroxylase....Pages 459-466
Front Matter....Pages 467-467
Effect of Polyamines on Protein Kinase C Activation Process....Pages 469-480
Interaction of Polyamines with Phospholipids: Spermine and Ca 2+ Competition for Phosphatidylserine Containing Liposomes....Pages 481-490
Bidirectional Transport of Spermine Across the Inner Membrane of Liver Mitochondria....Pages 491-496
Polyamines Stimulate the “In Vitro” Transport of the Precursor of Ornithine Carbamoyltransferase into Rat Liver Mitochondria....Pages 497-508
Uptake of Polyamines by Human Lymphocytes and Their Effect on Lactate Formation from Glucose....Pages 509-516
Theoretical and Experimental Characterization of Polyamine/DNA Interactions....Pages 517-523
Effect of Spermine on Transfer RNA and Transfer RNA-Ribosome Interactions....Pages 525-533
Spermine Inhibition of Basal and Stimulated Adenylate Cyclase is Mediated by the Inhibitory GTP-Binding Protein (G i )....Pages 535-543
Front Matter....Pages 545-545
Polyamines as Growth Substances in Higher Plants....Pages 547-558
Polyamines in Growth and Differentiation of Plant Cell Cultures: The Effect of Nitrogen Nutrition, Salt Stress and Embryogenic Media....Pages 559-572
The Di- and Polyamine Oxidases of Plants....Pages 573-587
Control of Phytopathogens by Inhibitors of Polyamine Biosynthesis....Pages 589-599
Relationship Between Polyamine and Ethylene Biosynthesis in Plants and its Significance for Morphogenesis in Cell Cultures....Pages 601-616
Purification of Polyamine Oxidase from Maize Seedlings by Immunoadsorbent Column....Pages 617-623
Front Matter....Pages 625-625
Polyamine Pools and the Control of Ornithine Decarboxylase Activity....Pages 627-632
Biochemical Properties of Unusual Polyamines Found in an Extreme Thermophile, Thermus thermophilus ....Pages 633-642
Polyamines in the Cell Cycle of the Malarial Parasite Plasmodium Falciparum ....Pages 643-650
The Role of Polyamines in the Growth and Transformation of the African Trypanosome....Pages 651-665
The Role of Glutathionylspermidine and Trypanothione in Regulation of Intracellular Spermidine Levels During Growth of Crithidia Fasciculata ....Pages 667-674
Front Matter....Pages 675-675
Regulation of Polyamine Biosynthetic Activity by Spermidine and Spermine Analogs — A Novel Antiproliferative Strategy....Pages 677-690
Front Matter....Pages 675-675
Fluorine-Containing Polyamines: Biochemistry and Potential Applications....Pages 691-706
Mechanism of Antitumor Activity of Norspermidine, a Structural Homologue of Spermidine....Pages 707-716
The Effects of Polyamine Analogues on Malaria Parasites In Vitro and In Vivo ....Pages 717-726
Inhibition of Ornithine or Arginine Decarboxylase as an Experimental Approach to African or American Trypanosomiasis....Pages 727-735
The Polyamine Metabolism of Filarial Worms as Chemotherapeutic Target....Pages 737-743
Large Bowel Tumor Promotion by Diamine Oxidase Inhibition: Animal Model and Clinical Aspects....Pages 745-752
Closing Remarks: Changing Perspectives in Polyamine Research....Pages 753-757
Back Matter....Pages 759-779