Pluripotent Stem Cells (Stem Cells - Laboratory and Clinical Research)

PLURIPOTENT STEM CELLS......Page 6
CONTENTS......Page 8
PREFACE......Page 10
Abstract......Page 16
Introduction......Page 17
Conclusion......Page 44
References......Page 45
Abstract......Page 62
Signal Transduction Pathways that Maintain\rPluripotency\r......Page 63
Transcriptional Network Governing Pluripotency in\rMouse and hESC\r......Page 73
Conclusion......Page 81
References......Page 82
Abstract......Page 96
1. Introduction: Generation of Induced Pluripotent Stem\r(iPS) Cells\r......Page 97
2. Explored / Proposed Alternative Strategies to Viral\rDelivery of Key Factors\r......Page 106
3. Experimental Application of iPS Cells for Therapy\r......Page 115
4. Applicability of iPS in Therapeutic Setting......Page 116
References......Page 121
Abstract......Page 128
Amniotic Fluid and Placenta in Developmental Biology......Page 129
Isolation and Characterization of Progenitor Cells......Page 131
In Vitro Differentiation of Amniotic Fluid and Placenta\rDerived Progenitor Cells\r......Page 134
Preclinical Studies in Animal Models......Page 140
Conclusion......Page 145
References......Page 146
Abstract......Page 152
Traditional Views on Tumorigenesis......Page 153
Ambiguity about the Origin of Cancer Stem Cells......Page 154
The Relevance of Epithelial-to-Mesenchymal Transitionin Cancer Biology......Page 155
Tumor-Initiating Cells of the Breast......Page 157
Stemness Properties in Other Epithelial Malignancies......Page 159
The CD133 Phenotype: Growing Evidence among Central\rNervous System Tumors\r......Page 160
Evidence for Side Populations in Cancer......Page 161
Future Insights......Page 162
References......Page 164
Abstract......Page 170
1. Introduction to iPS Technology......Page 171
2. Some Essential Questions Surrounding iPS......Page 174
3. Conclusions......Page 180
References......Page 182
Abstract......Page 188
References......Page 196
Abstract......Page 200
References......Page 205
Abstract......Page 206
1. Introduction\r......Page 207
2. Materials and Methods\r......Page 209
3. Results\r......Page 213
4. Conclusion\r......Page 220
References......Page 222
Abstract......Page 228
Immunogenicity of Human Embryonic Stem Cells and\rDifferentiated Cells\r......Page 229
Strategies for Immune Protection of Differentiated\rHuman Embryonic Stem Cells\r......Page 231
Parthenogenetically Activated Oocytes Give Rise to\rSyngeneic ES Cell Lines\r......Page 232
Derivation of Embryonic Stem Cells from Somatic Cell\rNuclear Transferred Oocytes and Zygotes\r......Page 234
Reprogramming of Somatic Cells by Fusion with\rEmbryonic Stem Cells\r......Page 235
Reprogramming Somatic Cells by Defined Factors......Page 236
Conclusion......Page 237
References......Page 238
Abstract......Page 242
Introduction......Page 243
Spontaneous and Experimental Teratomas and\rTeratocarcinomas\r......Page 250
Conclusion......Page 255
References......Page 256
INDEX......Page 262