Peptide Synthesis: Methods and Protocols

Front Matter ....Pages i-xi
 Solution Phase Peptide Synthesis: The Case of Biphalin  (Dagmara Tymecka, Aleksandra Misicka)....Pages 1-11
 Application of Fmoc-SPPS, Thiol-Maleimide Conjugation, and Copper(I)-Catalyzed Alkyne-Azide Cycloaddition “Click” Reaction in the Synthesis of a Complex Peptide-Based Vaccine Candidate Against Group A Streptococcus  (Chuankai Dai, Rachel J. Stephenson, Mariusz Skwarczynski, Istvan Toth)....Pages 13-27
 In Situ Neutralization Protocols for Boc-SPPS  (Ramkrishna Adhikary, Philip E. Dawson)....Pages 29-40
 Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis  (Kirtikumar B. Jadhav, Katrina J. Woolcock, Markus Muttenthaler)....Pages 41-57
 Automated Solid-Phase Peptide Synthesis  (Dirk F. H. Winkler)....Pages 59-94
 New Developments in Microwave–Assisted Solid Phase Peptide Synthesis  (Sandeep K. Singh, Jonathan M. Collins)....Pages 95-109
 Protecting Groups in Peptide Synthesis  (Martin Conda-Sheridan, Maddeboina Krishnaiah)....Pages 111-128
 Synthesis of O-Acyl Isopeptides: Stepwise and Convergent Solid-Phase Synthesis  (Taku Yoshiya)....Pages 129-138
 An Isodipeptide Building Block for Microwave-Assisted Solid-Phase Synthesis of Difficult Sequence-Containing Peptides  (Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth)....Pages 139-150
 SPOT Synthesis: The Solid-Phase Peptide Synthesis on Planar Surfaces  (Dirk F. H. Winkler)....Pages 151-173
 Solid-Phase Synthesis of Wollamide Cyclohexapeptide Analogs  (Allan M. Prior, Dianqing Sun)....Pages 175-187
 Synthesis of Branched Peptides via a Side-Chain Benzyl Ester  (Junjie Liu, Jian Li, Xiaobo Tian, Feng Tang, Wei Huang)....Pages 189-198
 Solid-Phase Synthesis of Octapeptin Lipopeptides  (Karl A. Hansford, Zyta M. Ziora, Matthew A. Cooper, Mark A. T. Blaskovich)....Pages 199-213
 Peptidomimetic Synthesis: Drug Discovery for Alzheimer’s Disease  (Yoshio Hamada, Zyta M. Ziora)....Pages 215-223
 Synthesis of Amide Backbone-Modified Peptides  (Abu-Baker M. Abdel-Aal, Richard Raz, George Papageorgiou, John Offer)....Pages 225-237
 Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis  (Piret Arukuusk, Ülo Langel)....Pages 239-247
 Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens  (Guanghui Zong, Chao Li, Lai-Xi Wang)....Pages 249-262
 Synthesis of Antimicrobial Lipopeptides Using the “CLipPA” Thiol-Ene Reaction  (Yann O. Hermant, Alan J. Cameron, Paul W. R. Harris, Margaret A. Brimble)....Pages 263-274
 Decarboxylative Couplings for Late-Stage Peptide Modifications  (Meng Yao Zhang, Lara R. Malins)....Pages 275-285
 Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs  (Artur Mucha, Paweł Kafarski)....Pages 287-301
 Microbioreactor Techniques for the Production and Spectroscopic Characterization of Microbial Peptides  (Zeinab G. Khalil, Angela A. Salim, Robert J. Capon)....Pages 303-322
 Metal–Peptide Complexes to Study Neurodegenerative Diseases  (Mariusz Mital, Jakub P. Sęk, Zyta M. Ziora)....Pages 323-336
Back Matter ....Pages 337-338