Peptide Science - Present and Future

Front Matter....Pages i-xxxxvi
From big molecules to smaller ones....Pages 1-5
Directions for solving the remaining problems in the synthesis of large peptides....Pages 6-14
Peptide science: past, present and future....Pages 15-20
Quo vadis? Where is peptide chemistry headed?....Pages 21-25
Designing peptidomimetic antagonists for peptide receptors: topochemical differences of agonists and antagonists....Pages 26-29
Self-assembling homopolymeric peptide tapes in aqueous solution....Pages 30-33
Peptides containing nonnatural amino acids with functional side groups....Pages 34-38
Active carbonates of N -protected amino alcohols for synthesis of carbamate pseudopeptides....Pages 39-40
Convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins and its application to the synthesis of bifunctional anti-HIV compounds....Pages 41-43
Stereoselective synthesis of two type ( E )-alkene dipeptide isosteres from a single substrate of β-aziridinyl- α,β-enoate....Pages 44-46
Design and synthesis of conformationally constrained dipeptide containing the α-fluoroglycine residue....Pages 47-48
Screening of peptidomimetic tyrosine kinase inhibitors for inducing programmed cell death....Pages 49-51
Molecular assembly of helix peptides vertically oriented on gold surface....Pages 52-53
Gramicidin vesicles — self-assembly in water composed of gramicidin A as hydrophobic core of membrane....Pages 54-56
Design, synthesis, and characterization of a dimeric analog of small globular protein (SGP) in solution and its biological and channel-forming activities....Pages 57-58
Molecular design of cyclic peptides containing a non-natural amino acid: novel synthetic approach to artificial ion channels....Pages 59-60
Structure based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor....Pages 61-63
A three-helix bundle metallopeptide destabilized at an acidic condition....Pages 64-66
The alamethicin-leucine zipper hybrid peptide: modulation of the assembling of transmembrane peptides through the extramembrane peptide segments....Pages 67-69
BCvir: backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in non-dividing cells....Pages 70-72
Self-assembling homopolymeric peptide tapes in moderately polar organic solvents....Pages 73-75
Substrate specificities of artificial flavo-enzymes....Pages 76-77
Catalytic activities of an artificial protein with designed loops....Pages 78-79
Catalytic activities of an artificial heme enzyme....Pages 80-81
A novel dioxopiperazine suitable as a β-turn constraint....Pages 82-84
Amphiphilic β-structure formed by oligopeptides composed of alternating hydrophic and hydrophobic residues....Pages 85-87
Design of cyclic antimicrobial peptides with low hemolytic activity....Pages 88-91
Synthesis and characterization of linear and cyclic oligopeptides of 5-alkyl-substituted 3-aminobenzoic acids....Pages 92-94
Theoretical analysis of βββββ-type packing motifs formed by alternate intramolecular arrangements of three β-helices and three β-strands....Pages 95-97
Theoretical analysis of β-type packing motifs formed by intramolecular arrangements of β- strands....Pages 98-100
Theoretical analysis of βββ-type packing motifs formed by intramolecular arrangements of two β-helices and two β-strands....Pages 101-103
Self-catalytic conversion of peptides from β-helix to β-structural amyloid....Pages 104-106
Design, synthesis and characterization of heme-conjugated two-β-helix peptides....Pages 107-109
Self-assembly of heme-conjugated two-β-helix peptides....Pages 110-112
Construction of porphyrin-binding peptides mimicking anti-heme monoclonal antibody....Pages 113-114
Construction of cyclodextrin-peptide conjugates and their molecular sensing properties....Pages 115-116
Interaction of bundled Ser-rich peptides with phospholipid bilayer....Pages 117-118
Topographically designed analogues of c[ d -Pen 2 , Pen 5 , Nle 6 ] deltorphin I with stereoisomers of β-MePhe or β-iPrPhe in position 3....Pages 119-120
Engineering novel mini-proteins by the transfer of active sites to small disulfide stabilized natural scaffolds....Pages 121-122
Preparation of heterocyclic positional scanning combinatorial libraries from peptides....Pages 123-127
Design and synthesis of a lactam bridge stabilized coiled-coil template for library display....Pages 128-131
Diversity of synthetic peptides....Pages 132-133
Manual construction of combinatorial resin bound tripeptide library (one peptide on one bead) and screening to find antioxidative peptides....Pages 134-135
Selection of peptides that bind to β-lactalbumin from phage display library....Pages 136-138
Identification of a novel analgesic peptide including an unnatural amino acid from peptide libraries synthesized with a multipeptide synthesizer....Pages 139-140
Artificial proteins screened from combinatorial chemical libraries with strong binding to double-stranded oligodeoxyribonucleotides: towards repressors to long terminal repeat controlled viral transcription....Pages 141-143
Synthesis, conformational analysis and application of tropane-based Fmoc-amino acid derivatives: novel antagonists of fibrinogen receptor, GPIIb/IIIa....Pages 144-145
Accurate peptide sequencing by mass spectrometry....Pages 146-151
Characterization of sulfhydryl compounds attached to the cysteinyl residue of proteins or peptides by on-line post-column derivatization....Pages 152-153
Regioselective hydrolytic cleavage of N -terminal myristoyl-peptide....Pages 154-156
Selective removal of pyroglutamic acid residue from biologically active pyroglutamyl-peptides by aqueous methanesulfonic acid....Pages 157-159
Hydrolytic removal of acetyl-amino acid from acetyl- peptide in methanesulfonic acid....Pages 160-162
Determination of the binding-site structure of the atrial natriuretic peptide receptor by stepwise-affinity alkylation....Pages 163-165
Structure of glycoside of Bombyx mori prothoracicotropic hormone....Pages 166-167
Photophysics of sterically constrained phenylalanines....Pages 168-170
Addressing combinatorial and peptide analysis by using overpressured layer chromatography in comparison with high-performance liquid chromatography and capillary electrophoresis....Pages 171-173
AVP(4–8)-induced branching signaling pathway was mediated by a putative GPCR in rat brain....Pages 174-178
The mechanisms of exocytosis induced by neurokinin peptides in mast cells....Pages 179-182
Effects of dynorphins on free cytoplasmic calcium concentration and insulin release in ob/ob mouse pancreatic β-cells....Pages 183-184
The effect of magnesium ions on the uterotonic activity of oxytocin analogs....Pages 185-187
Human thymopoietin beta-fragments: synthesis and antibody studies....Pages 188-189
Cholecystokinin receptor parameters responsible for specific cellular signalling....Pages 190-192
Sweetness-suppressing activities of gurmarin analogues missing one disulfide bond....Pages 193-194
Modeling of the somatostatin receptor (hsst3)-ligand complex....Pages 195-197
Structural requirements of hyperalgesic nociceptin in receptor binding and activation....Pages 198-199
Activation of phosphatidylinositol 3-kinase via epidermal growth factor receptor in isolated rat hepatocytes....Pages 200-201
Agonist-antagonist structure-activity relationships of thrombin receptor tethered ligand peptide....Pages 202-204
The first extracellular loop of the rat glucagon receptor contains determinants of glucagon binding....Pages 205-206
A novel type of rat brain β opioid receptors differenciated by cyclopropylphenylalanine-containing enkephalin analog....Pages 207-209
Synthesis of dimeric novobiocins as chemical inducers of dimerization for DNA gyrase-fused proteins....Pages 210-211
Computer biochemistry and molecular physiology of the natural peptide ligands: different functional groups....Pages 212-214
Bacterial peptide pheromone is imported where it directly binds to an intracellular receptor....Pages 215-217
Grb2 SH2 domain targeted inhibitors functioning in cellular signaling....Pages 218-220
74]Interaction between heat-stable enterotoxin and its receptor (guanylyl cyclase C): Influence of mutation at N -linked glycosylation sites on its ligand binding....Pages 221-222
Receptor studies with novel insulin analogues and photoaffinity labelling techniques....Pages 223-225
Radioligands for the receptor of mammalian melanin-concentrating hormone (MCH)....Pages 226-227
Using peptides to study the folding of a predominantly β-sheet protein....Pages 228-231
β-Helical propensity of Ala-based peptides in organic solvents....Pages 232-234
Effects on folding properties of endothelin/apamin by incorporation of selenocysteine into their cysteine framework....Pages 235-239
Peptide conformational behaviour studied by high and low temperature reversed phase HPLC....Pages 240-244
Three-dimensional structure and receptor-recognition sites of bombyxin-II, an insulin-like brain-secretory peptide of the silkmoth....Pages 245-248
C β -Methyl, C β -phenylglycine peptides....Pages 249-250
Graphite-mimetic peptides....Pages 251-252
The E. Fischer’s octadecapeptide revisited after 90 years....Pages 253-254
Conformational analysis of peptide fragments corresponding to domains of potassium ion-channel proteins....Pages 255-256
Conformation and sweet taste of l -Asp- d -Xaa-OMe dipeptides....Pages 257-259
Conformations of four cyclic tetrapeptides containing two Pro residues....Pages 260-262
Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with dodecylphosphocholine micelles....Pages 263-265
Formation of native disulphide bonds in endothelin-1: evidence for the involvement of a highly specific salt-bridge between the pro-sequence of endothelin-1 and mature sequence....Pages 266-268
Structure-biological activity relationships of cecropin A (1–8)-magainin 2 (1–12) hybrid and its analogues....Pages 269-270
Structure-activity relationship of βagatoxin-TK, a peptide blocker of P/Q-type calcium channels....Pages 271-273
Peptide scanning in structural -functional mapping of hemeproteins....Pages 274-276
Structure analysis of the second transmembrane segment of the rat bradykinin receptor in solution and in micelles by CD and fluorescence spectroscopies....Pages 277-279
Conformational analysis of antimicrobial peptide tachystatin A isolated from horseshoe crab hemocytes by two dimensional 1 H NMR spectroscopy....Pages 280-281
Solution structure of β-conotoxin MI determined by 1 H-NMR spectroscopy and molecular dynamics simulation with the explicit solvent water....Pages 282-283
Study of depsipeptide Boc-(Leu-Leu-Ala) 2 -(Leu-Leu- Lac) 3 -OEt forming 3 1 0 -helix....Pages 284-285
 1 H Nuclear Magnetic Resonance analysis of [Ser 6 , Ser 20 ]-human-Epidermal Growth Factor as a model for the intermediate of the disulfide folding pathway....Pages 286-287
p K a shift by NH⋯S hydrogen bond in the hair-pin turn structure of Cys-containing oligopeptides....Pages 288-290
Effect of environment on the stability of helical Aib-model peptides....Pages 291-293
Structural analysis of mastoparan by solid-state nuclear magnetic resonance....Pages 294-296
Four-helix bundle formation only through special pathway via micelle state....Pages 297-299
Synthesis of peptides containing 9-aminofluorene- 9-carboxylic acid by the modified Ugi reaction....Pages 300-302
Effects of mutations on tetramer formation of tumor suppressor protein p53....Pages 303-305
Disulfide-coupled folding of the circulating form of uroguanylin....Pages 306-308
Solution structure of the extracellular domain of type-I receptor for bone morphogenetic protein-2/4 as studied by nuclear magnetic resonance spectroscopy....Pages 309-310
Comparison of three-dimensional solution structures of dendrotoxin I, a potassium channel blocker, and calucicludine, a calcium channel blocker, determined by nuclear magnetic resonance spectroscopy....Pages 311-312
Sequence, conformation, and function of peptides, retro peptides and sense and antisense gene products....Pages 313-315
Ion conductance in a gramicidin channel: the right-handed double-stranded double-helical dimer....Pages 316-318
Protein folding intermediates and Alzheimer’s disease....Pages 319-321
Topological isomers of human uroguanylin: function and conversion....Pages 322-323
Topological isomers of human uroguanylin: structure determination by nuclear magnetic resonance....Pages 324-325
Homology modelling of the glycoprotein hormones: examination of the receptor recognition characteristics....Pages 326-329
Prion protein structure and pathology of transmissible spongiform encephalopathies (TSE)....Pages 330-334
Peptide nucleic acid (PNA)....Pages 335-341
Receptor based design, synthesis and biology of novel somatostatin analogs....Pages 342-345
NMR structure of mastoparan-X bound to G protein β subunit....Pages 346-350
Peptides and molecular recognition: head-to-tail self-assembly, formation of amphipathic surfaces and recognition of anionic superhelices....Pages 351-356
Non-immobilised ligand interaction assay (NILIA) — the CD approach....Pages 357-359
Characterization and evolutionary aspect of a Trimeresurus flavoviridis serum inhibitor, PLI-I, against its venom basic phospholipase A 2 isozymes....Pages 360-361
A 24 mer peptide with activities of discrimination and recombination of nucleic acids....Pages 362-363
Phosphorylation of synthetic peptides containing proline homologs by cdc2 kinase or cdk5....Pages 364-366
Synthesis of oligomerization domain of p53 and its analogs and their association properties in buffer solution....Pages 367-369
Stabilization of tyrosine- O -sulfate residues through the formation of a conjugate acid-base pair....Pages 370-372
Circular dichroism and fluorescence study of the interaction of synthetic J protein from bacteriophage βK with DNA....Pages 373-375
Unusual collagen assembly induced by acidic biopolymers in vitro ....Pages 376-378
The role of nucleoplasmin — molecular chaperone protein — in the fertilization process....Pages 379-380
Conformation of chick DNA topoisomerase I as determined by limited proteolysis....Pages 381-382
The two adenosine triphosphate and nucleic acid binding sites of the calf thymus single-strand DNA-dependent adenosine triphosphatase....Pages 383-384
Induced helical structure in highly charged peptides....Pages 385-387
Nociceptin, a novel neuropeptide with multiple functions....Pages 388-397
An anti-HIV peptide T22 is confirmed to be a selective CXCR4/fusin inhibitor by comparative inhibition study of a chemokine SDF-1, synthesized by regioselective disulfide bond formation....Pages 398-402
Isolation of the nucleoplasmin-like molecular chaperone protein from salmon egg....Pages 403-406
Study of neurotoxic peptides from Chinese scorpion Buthus martensi Karsch....Pages 407-410
Impervious peptides as growth hormone secretagogues....Pages 411-412
Effect of carnosine and its natural derivatives on apoptosis of neurons induced by excitotoxic compounds....Pages 413-415
Morphological differences observed by the different modes of action of the antibacterial peptides, cecropin B and its analogs CB-1, CB-2 and CB-3 on bacterium and cancer cell....Pages 416-418
Isolation and characterization of bioactive peptides from the sea cucumber, Stichopus japonicus ....Pages 419-420
Purification of peptide fractions with anticomplementary activity from red ginseng ( Panax ginseng , C.A. Meyer)....Pages 421-423
HIV-cell fusion inhibitor, T22 ([Tyr 5,12 , Lys 7 ]-polyphemusin II), and its related compounds....Pages 424-426
Efficient analogs of an anti-HIV peptide, T22 ([Tyr 5,12 , Lys 7 ]-polyphemusin II), having low cytotoxicity....Pages 427-429
Cyclic RGD peptides with a novel mimetic....Pages 430-431
Isolation and cDNA cloning of oryctin, a novel cysteine-rich antibacterial peptide, from the coconut rhinoceros beetle, Oryctes rhinoceros ....Pages 432-433
Eumenine mastoparans. A new class of mast cell degranulating peptides in the eumenine wasp venom....Pages 434-435
Direct evidence of the generation of lactoferricin from ingested lactoferrin....Pages 436-438
Human immunodeficiency virus type 1 Vif-derived peptides inhibit the viral protease and arrest virus production....Pages 439-441
A novel cardioactive peptide of Aplysia contains a d -amino acid residue....Pages 442-443
Purification and primary structure of four novel neuropeptides in Aplysia kwrodai ....Pages 444-445
Structure and function of fragments of antibiotic bactenecin 5....Pages 446-447
Production of adrenomedullin in macrophages....Pages 448-449
Adrenomedullin production in fibroblast cell lines....Pages 450-452
Chemical and biological characterization of neuropeptides in the sinus glands of the kuruma prawn, Penaeus japonicus ....Pages 453-454
Preparation of a poly(ethylene glycol) hybrid containing two active fragments of laminin....Pages 455-456
Modification of an anti-fungal peptide (ESF-1) for enhanced inhibitory activity and resistance to proteolysis....Pages 457-459
Structure determination and cDNA cloning of paralytic peptide in Bombyx mori ....Pages 460-461
Isolation and characterization of a bacteriocin-like peptide produced by Brevibacterium linens ATCC 9172, an orange cheese coryneform bacterium....Pages 462-464
Synthesis, conformational analysis, and biological activity of opioid peptide analogs containing side chain fluorinated amino acids....Pages 465-466
Structural requirement tryptophan 1,3 of tridecapeptide mating pheromone of Saccharomyces cerevisiae ....Pages 467-469
Synthesis and in vitro effects of short analogues of β-amyloid peptide on resting transmembrane potential....Pages 470-471
Macrotorials: synthesis and characterization of model compounds related to PTH (1–34)....Pages 472-474
Developments in peptide synthesis and peptidomimetic chemistry: HIV protease analogs and substrate-based inhibitors....Pages 475-479
Thia zip reaction for the facile synthesis of large cyclic peptides....Pages 480-484
Synthesis of disulfide-bridged heterotrimeric collagen peptides. Conformational properties and digestion by matrix metalloproteinases....Pages 485-489
Combined solid-phase and solution approach to protein synthesis....Pages 490-494
A simple linker for the attachment of aldehydes to the solid phase. Application to solid phase synthesis by the Multipin™ method....Pages 495-497
Stereoselective synthesis of dehydroaminobutyric acid....Pages 498-499
Efficient preparation of dehydroalanine derivatives....Pages 500-501
Totally stereocontrolled synthetic routes for ( E )-alkene dipeptide isosteres....Pages 502-503
Synthesis of protected 2,3-epoxy amines utilizing aza-Payne rearrangement of activated 2-aziridinemethanols under basic conditions....Pages 504-506
Convenient preparation of phosphopeptide fragments using High TFMSA system and its application to synthesis of long chain phosphopeptides....Pages 507-509
An efficient synthesis of tryptophan-containing cystine peptide using the silyl chloride-sulfoxide system....Pages 510-511
Synthesis of an HIV-1 protease dimer analog covalently linked by a disulfide bridge....Pages 512-513
Enzymatic peptide synthesis using activated esters as acyl donors in organic media....Pages 514-515
Facile synthesis of the acid-labile peptide amide linker containing the 10, 11-dihydro-5 H -dibenzo [ a, d ] cyclohepten-5-yl group....Pages 516-518
Synthetic approach to microsclerodermins....Pages 519-520
Synthetic approach to caledonin, a natural bolaphile....Pages 521-522
Synthetic approach to antillatoxin, an exceptionally ichthyotoxic cyclic lipodepsipeptide....Pages 523-524
Desulfation vs. deprotection: direct solid-phase synthesis of Tyr(SO 3 H)-containing peptides using the S n 1-type deprotection procedure....Pages 525-526
Enzymatic syntheses of oligopeptides in organic solvents....Pages 527-529
Studies of racemization in peptide synthesis for a phosphoryloxy-benzotriazin-one coupling reagent (DEPBT)....Pages 530-533
Effect of polyethylene glycol on the synthesis of oligopeptides by proteases in an organic medium....Pages 534-535
Synthesis of a cyclic tetrapeptide related to trapoxin B....Pages 536-538
Highly efficient solid phase cyclization of peptides by methylenedithioether or disulfide bond formation....Pages 539-541
4-(2-(1-Hydroxyethyl)-1,3-dithiacyclohex-2-yl)-phenoxyacetic acid (HETPA): photolabile linker for Fmoc solid phase synthesis....Pages 542-544
Kinetic study of the pseudolysin-catalyzed synthesis of Z-Ala-Phe-NH2....Pages 545-546
Solid phase peptide synthesis using 2-(4-Nitrophenyl)-sulfonylethoxycarbonyl (NSC) amino acids for Luteinizing hormone-releasing hormone (LHRH)....Pages 547-549
Novel synthesis through repeated S -cyanocysteine mediated segment condensations....Pages 550-551
Total synthesis of human pleiotrophin, a 136-residue heparin-binding neurotrophic factor having five disulfide bonds....Pages 552-554
Engineering of snake venom cardiotoxin by chemical synthesis approach....Pages 555-577
Specificity of Cardosins A and B in peptide synthesis....Pages 558-559
A facile preparation of 2,2-difluoro-1,3,2-oxazaborolidin- 5-ones(I) and their application to side-chain protection of Asp, Glu, Ser and Thr....Pages 560-562
ESR-resin solvation approach for the investigation of the highly peptide-loaded synthesis protocol....Pages 563-565
Synthesis of β-amino phosphonic acids by catalytic asymmetric hydrogenation....Pages 566-568
Process impurity identification in MSI-78....Pages 568-570
Identification of unknown intermediate during methanolysis of Z-Lys (Boc)—OSu....Pages 571-573
Synthesis of phosphorylated polypeptide by a thioester method....Pages 574-575
Synthesis of reaper protein by a thioester method using silver chloride as an activator....Pages 576-578
Preparation of a peptide thioester by a 9-fluorenylmethoxycarbonyl solid phase method....Pages 579-580
Chemical synthesis of barnase which possesses phosphoserine residue in place of the catalytic glutamic acid at position 73....Pages 581-583
Disulfide oxidation in water: investigation of CLEAR supports for on-resin cyclization....Pages 584-586
Non-natural peptide modifications using sugars and lipophilic side chains....Pages 587-594
Diastereoselective synthesis of glycosyl-β-aminoacids and glycopeptide derivatives....Pages 595-599
Influence of glycation on cis/trans isomerization and tautomerization in novel morphiceptin-related Amadori compounds....Pages 600-602
Chemoenzymatic synthesis of glycophosphopeptides....Pages 603-604
Design and synthesis of novel Src homology-2 domain inhibitors....Pages 605-606
Chemo-enzymatic syntheses of eel calcitonin analogs having natural N -linked oligosaccharides....Pages 607-609
Chemo-enzymatic synthesis of bioactive peptide derivatives containing N -linked oligosaccharides....Pages 610-612
Optimization of N,N ′-dialkyldiamide-type phosphate protecting group for phosphopeptide synthesis....Pages 613-614
Solid phase synthesis of O -glycopeptide — Preparation of O -( N -acetylgalactosaminyl)-threonine derivative and its application to peptide synthesis....Pages 615-617
Design of novel, nonpeptide oxytocin receptor antagonists....Pages 618-622
Development of potent non-peptide GPIIb/IIIa antagonists with tri-substituted β-amino acid derivatives as a new conformational restriction unit....Pages 623-627
Design and synthesis of potent and selective inhibitors of the osteoclast-specific cysteine protease, cathepsin K....Pages 628-630
Difference of structural requisite in design of inhibitor of cathepsin B and papain: X-ray crystal structures of complexes....Pages 631-633
Synthesis of peptides with aziridine-2,3-dicarboxylic acid as an β-amino acid equivalent building block....Pages 634-636
Isolation and characterization of prolyl endopeptidase-inhibiting peptides from bovine brain....Pages 637-638
Structure based design and synthesis of novel orally active thrombin inhibitors....Pages 639-641
Design of bivalent plasmin inhibitors....Pages 642-643
Suicide-inhibition of human immunodeficiency virus type-1 protease by the gag precursor processing product (p2 gag peptide)....Pages 644-645
Design of plasma kallikrein selective inhibitor and its application to affinity chromatography....Pages 646-648
Structural essentials for novel inhibition of serine protease chymotrypsin....Pages 649-651
KNI-764, A novel dipeptide-based HIV protease inhibitor containing allophenylnorstatine....Pages 652-653
Self-association of cystatin....Pages 654-656
The substrate specificity of microbial carboxyl proteinases....Pages 657-659
Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 and P2′ ligands....Pages 660-661
Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 ligands....Pages 662-664
Opioid peptide analogs with novel activity profiles as potential therapeutic agents for use in analgesia....Pages 665-669
Peptide radiopharmaceuticals: studies of somatostatin receptors and ligands for tumor targeting....Pages 670-673
Fatty acid acylated insulins display protracted action due to binding to serum albumin....Pages 674-677
Melanotropin fragments containing difluoromethylornithine: synthesis and cytotoxicity....Pages 678-680
Synthesis of RANTES-related peptides and their effect on human immunodeficiency virus-1 infection....Pages 681-683
The influence of structural motifs of amphipathic peptides on the permeabilization of lipid bilayers and the antibacterial and hemolytic activity....Pages 684-686
Proline at position 14 of alamethicin is essential for the hemolytic activity, catecholamine secretion from chromaffin cells and enhanced metabolic activity in endothelial cells....Pages 687-688
Enkephalin metabolism in rat brain after bestatin administration....Pages 689-690
Synthetic antibacterial peptides derived from insect defensin isolated from a beetle, Allomyrina dichotoma ....Pages 691-692
Do peptide antioxidants increase neuron viability by direct antioxidant effect?....Pages 693-694
Synthesis and characterization of β-conotoxin TxVII....Pages 695-696
Design and synthesis of antifungal lactoferricin derivatives....Pages 697-698
Incorporation of the nuclear localization signal (NLS) peptide-albumin conjugate to macrophages using pH-sensitive liposomes....Pages 699-700
Dermorphin-dynorphin hybrid analogs: Opioid receptor selection and enzymatic stability....Pages 701-703
Selective cytotoxicity of dermaseptins....Pages 704-706
Synergism of antimicrobial peptides, magainin 2 and PGLa, in liposomes....Pages 707-708
Cell specific gene transfer using galactose-modified peptide....Pages 709-710
Synthesis and biological activities of hPTH)1—34) analogues: modification of the middle part and C -terminal alkylamides....Pages 711-713
Absolute importance of arginine residue at position 7 of dog neuromedin U-8 for contractile activity....Pages 714-715
Cyclic peptides having inhibitory site of β-amylase inhibitor tendamistat....Pages 716-718
Doxorubicin liposomal preparations coated with Laminin related peptides....Pages 719-721
Importance of hydrophobic region in cationic peptides on gene transfer into cells and enhance effect of lysosome-disruptive peptide....Pages 722-723
Synthesis and pharmacological properties of oxytocin antagonists containing conformationally constrained amino acids....Pages 724-725
Identification of the structural elements responsible for high biological activity of dimeric opioid peptide biphalin....Pages 726-727
Orally active memory-enhancing peptides obtained by designing bioactive peptides derived from food proteins....Pages 728-730
Dimers of bradykinin and substance P antagonists as potential anti-cancer drugs....Pages 731-732
Ovine Leydig cell insulin-like peptide: a sheep relaxin?....Pages 733-736
Self-assembling peptides in biology, materials science and engineering....Pages 737-744
Hybridization properties of nucleic acid analogs bearing peptide backbone....Pages 745-747
Copper(II) complexes of the modified ACTH active center analogue hexapeptides — investigation by means of CD spectroscopy....Pages 748-749
The structure—activity relationships of the sweet protein brazzein — roles of acidic amino acids....Pages 750-751
Asymmetric synthesis of β-amino acids: Dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary....Pages 752-754
The function and insertion of a d -Serine residue in β- agatoxin-TK....Pages 755-756
Physiological role of the delta sleep-inducing peptide (DSIP)....Pages 757-758
Comparison of secondary structure and antibacterial activity of bactericidal peptides derived from bovine and Korean native goat lactoferrin....Pages 759-760
Synthesis of enantiomerically pure non proteinogenic β-amino acids....Pages 761-763
Improvements of activity and stability against proteases of biologically active peptides by coupling of a cyclic peptide derived from an endothelin antagonist RES-701-1....Pages 764-766
Structure-activity relationship of cyclic depsipeptides, AM-toxin analogs....Pages 767-769
Effects of chemical modification of Ca 2+ -dependent lectin CEL-III on its hemolytic and carbohydrate-binding activities....Pages 770-771
Coacervation of elastomeric polypeptides: microscopic observations and light scattering measurements....Pages 772-774
Preparation and properties of novel gramicidin S analogs possessing a polymethylene bridge between ornithine side chains....Pages 775-776
Effect of nitroprusside on amyloid peptide induced inhibition of MTT reduction in pheochromocytoma PC12h and C1300 neuroblastoma cells....Pages 777-778
Practical approach to enzymatic resolution of Fmoc- and Boc-protected amino acid racemates....Pages 779-781
Rapid translocation of amphipathic βhelical and β-sheet-forming peptides through plasma membranes of endothelial cells....Pages 782-783
Peptide analogues as vaccines and immunomodulators....Pages 784-787
Combinatorial peptide libraries and molecular recognition in T-cell mediated immune response....Pages 788-791
On the puzzle of the acute phase reactants C-reactive protein and serum amyloid A....Pages 792-796
Design of peptidic and non-peptidic CD4 inhibitors as novel immunotherapeutic agents [1–5]....Pages 797-800
Molecular design of T cell-costimulatory peptides for vaccine development....Pages 801-802
The identification of dominant epitopes of h-FKBP-12 recognized by monoclonal antibodies, 3F4 and 2C1, against h-FK-506 binding protein 12(h-FKBP-12)....Pages 803-804
Contribution of peptide backbone atoms to binding of an antigenic peptide to class I major histocompatibility complex molecule....Pages 805-807
B cell and T cell epitopes of Der f 2, a house dust mite major allergen of the Dermatophagoides farinae ....Pages 808-809
Conformational and binding studies of the peptide isolated from phage display library by anti-mouse CTLA-4 monoclonal antibody....Pages 810-812
Formation of DNA-anti-DNA antibody immune complex on collagen matrix....Pages 813-815
Natural IgM antibodies against human endogenous retroviruses HERV-H demonstrated by means of synthetic peptides....Pages 816-817
Evaluation of region-specific antibodies for rat and human Chromogranin A with use of synthetic peptide....Pages 818-819
Design of synthetic antigen containing non-immunogenic T cell epitope core and simple non-native flanking regions....Pages 820-822
Immune response to newly exposed regions of Band 3 protein of the red blood cell membrane during malaria infections....Pages 823-824
Peptide-induced antibodies as a tool to link genomes and proteomes....Pages 825-827
Porphyrin-peptide conjugates with stabilized helices and sheets....Pages 828-830
Molecular recognition of cyclic HIV protease inhibitors: highly orally-bioavailable DMP851....Pages 831-832
Back Matter....Pages 833-842