Oxygen Sensing: Responses and Adaption to Hypoxia

INTRODUCTION......Page 11
FOREWORD......Page 13
PREFACE......Page 15
CONTRIBUTORS......Page 17
CONTENTS......Page 27
Part One Genomics of Oxygen Sensing......Page 40
Biochemistry and Physiological Importance of Heme Proteins as Oxygen Sensors......Page 46
A Role for the Mitochondrion and Reactive Oxygen Species in Oxygen Sensing and Adaptation to Hypoxia in Yeast......Page 62
Regulation of HIF-1 by Oxygen......Page 86
Oxygen- or Redox-Dependent Regulation......Page 106
Structure and Regulation of the Mouse Hypoxia-Inducible Factor-1a Gene......Page 122
Hypoxia-Inducible Factor-1......Page 134
Brain Microvascular and Metabolic Adaptation to Prolonged Mild Hypoxia......Page 148
Molecular Adaptation to Hypoxia......Page 162
Regulation of Tyrosine Hydroxylase Gene Expression by Hypoxia in Neuroendocrine Cells......Page 192
Genome-wide Computational Screen for Candidate HIF Target Genes in Drosophila melanogaster and Caenorhabditis elegans......Page 214
Part Two OXYGEN SENSING IN THE CAROTID BODY, AND OTHER CELLS, ORGANS, AND ORGANELLES......Page 240
Fetal Adaptations to Hypoxia......Page 248
Perinatal Transition of Oxygen Sensing in the Peripheral Chemoreceptors......Page 274
Postnatal Maturation of the Carotid Chemoreceptor O2 Sensitivity at the Cellular Level......Page 290
Maturation of Chemoreceptor O2 and CO2 Sensitivity......Page 312
Further Evidence That Oxygen Sensing in the Carotid Body Involves Iron and Heme Proteins......Page 328
O2-Sensitive K+ Channels Controlling Cell Excitability......Page 338
Carotid Body Thin Slices......Page 354
Electric and Dye Coupling Between Rat Carotid Body Cells and Between These Cells and Carotid Nerve Endings......Page 370
From Oxygen Sensing to Chemosensory Activity......Page 392
Excitation of Glomus Cells......Page 404
Some Neurotransmitter Relationships in the Carotid Body’s Response to Hypoxia......Page 420
Effects of Nitric Oxide on Carotid Body Oxygen Consumption at Low PO2......Page 434
Nitric Oxide and Carotid Body Chemoreception......Page 448
Multiple Roles of Neurotransmitters in the Carotid Body......Page 460
Mechanisms of Morphological and Functional Plasticity in the Chronically Hypoxic Carotid Body......Page 478
Neurochemical Processes Involved in Acclimatization to Long-Term Hypoxia......Page 506
Biology of Reactive Oxygen Species......Page 528
Optical Analysis of the Oxygen-Sensing Signal Pathway......Page 546
Mitochondria as Vascular Oxygen Sensors......Page 562
Roles for NAD(P)H Oxidases as Vascular Oxygen Sensors and Their In.uence on Oxidant-Regulated Signaling Mechanisms......Page 592
Oxygen Sensing in Pulmonary Neuroepithelial Bodies and Related Tumor Cell Model......Page 606
Oxygen Sensing by Neonatal Adrenal Chromaf.n Cells......Page 642
O2 Sensing in Neurons......Page 658
Oxygen Sensitivity of Central Cardiorespiratory Regions......Page 672
Oxygen Sensing by the Brainstem in Respiratory Control......Page 690
Petrosal Ganglion Responses In Vitro......Page 710
Comparative Aspects of O2 Chemoreception......Page 724
AUTHOR INDEX......Page 748
SUBJECT INDEX......Page 804