Mouse Liver Tumors: Relevance to Human Cancer Risk Symposium of the European Society of Toxicology Held in Rome, February 2–5, 1986

Front Matter....Pages i-vi
Front Matter....Pages 1-1
The Mouse in Safety Evaluation....Pages 3-9
Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position....Pages 10-26
Front Matter....Pages 27-27
Invasiveness, Metastasis, and Transplantability of Mouse Liver Nodules....Pages 29-42
Xenobiotic-Induced Peroxisome Proliferation: Role of Tissue Specificity and Species Differences in Response in the Evaluation of the Implications for Human Health....Pages 43-53
The Role of Necrosis in Hepatocellular Proliferation and Liver Tumors....Pages 54-67
Biological Markers Characterizing the Development of Preneoplastic and Neoplastic Lesions in Rodent Liver....Pages 68-80
Relationship Among Histochemically Distinguishable Early Lesions in Multistep-Multistage Hepatocarcinogenesis....Pages 81-94
The Histopathology and Biochemistry of Phenobarbitone-Induced Liver Nodules in C3H Mice....Pages 95-107
Front Matter....Pages 109-109
Species Differences in Enzymes Controlling Reactive Epoxides....Pages 111-124
Species Differences of Glucuronidation and Sulfation in Relation to Hepatocarcinogenesis....Pages 125-135
Glutathione S-Transferase Subunits in the Mouse and Their Catalytic Activities Towards Reactive Electrophiles....Pages 136-146
Species Differences in Biotransformation of and Peroxisome Proliferation Due to Trichloroethylene....Pages 147-147
The Distribution of Carcinogen Metabolizing Enzymes in the Mouse Liver: Comparison of Parenchymal and Non-Parenchymal Cell Populations....Pages 148-156
Investigations on the Mechanism of Liver Tumour Induction by Peroxisome Proliferators....Pages 157-161
DNA Damage and Repair in Mouse Liver....Pages 162-171
Individual Differences in DNA Repair Capacities in Man....Pages 172-179
Variables Influencing DNA-Binding in Mouse Liver....Pages 180-189
Pharmacokinetic Factors and Their Implication in the Induction of Mouse Liver Tumors by Halogenated Hydrocarbons....Pages 190-203
Comparative Study on the Indirect Methylation of Liver DNA Guanine by the 1-Carbon Pool in Hepatotoxicity....Pages 204-216
Activation of a Cellular Proto-Oncogene in Spontaneous Liver Tumor Tissue of the B6C3F1 Mouse....Pages 217-227
Front Matter....Pages 229-229
Nutritional and Dietary Influences on Liver Tumorigenesis in Mice and Rats....Pages 231-243
Anatomy, Function and Aging in the Mouse Liver....Pages 244-250
Sex Hormones and Neoplasia: Liver Tumors in Rodents....Pages 251-263
Sex Hormones and Neoplasia: Genotoxic Effects in Short Term Assays....Pages 264-278
Front Matter....Pages 279-279
Pathogenesis of Experimental Liver Cancer: Comparison with Humans....Pages 281-288
Back Matter....Pages 289-295