Molecular Recognition: Biotechnology, Chemical Engineering and Materials Applications

MOLECULAR RECOGNITION: BIOTECHNOLOGY, CHEMICAL ENGINEERING AND MATERIALS APPLICATIONS......Page 3
MOLECULAR RECOGNITION: BIOTECHNOLOGY, CHEMICAL ENGINEERING AND MATERIALS APPLICATIONS......Page 5
CONTENTS......Page 7
PREFACE......Page 9
ABSTRACT......Page 15
1. INTRODUCTION......Page 16
2.1. MACROCYCLIC POLYAMINES......Page 18
2.2. PROTONATED HETEROCYCLES......Page 22
2.3. RECEPTORS WITH GUANIDINE AND AMIDINE FUNCTIONS......Page 25
2.4. RECEPTORS CONTAINING UREA AND THIOUREA MOIETIES......Page 27
2.5. RECEPTORS CONTAINING AMIDE GROUP......Page 30
2.6. RECEPTOR WITH AMIDOPYRIDINE FRAGMENT......Page 32
2.7. METAL-BASED RECEPTORS......Page 34
2.8. RECEPTORS BASED ON CYCLODEXTRINS AND CALIXARENES......Page 38
ACKNOWLEDGMENTS......Page 47
REFERENCES......Page 48
ABSTRACT......Page 59
INTRODUCTION......Page 60
1. LIQUID CRYSTAL MIPS......Page 62
I.1. CHIRAL RECOGNITION IN LC-MIPS......Page 63
I.2. CATALYTIC LC-MIPS......Page 67
I.3. APPLICATION TO THE RECOGNITION OF PESTICIDES......Page 70
II. HYDROGEL MIPS FOR PROTEIN RECOGNITION......Page 73
II.1. RECENT ACCOMPLISHMENTS......Page 74
II.2. PATTERNING OF MIPS FOR MICRO- AND NANOSYSTEMS APPLICATIONS......Page 81
CONCLUSION......Page 86
REFERENCES......Page 87
1. INTRODUCTION: SUPRAMOLECULAR CHEMISTRY  AND MOLECULAR RECOGNITION......Page 93
2.1. DRUG ACTION MECHANISM......Page 99
2.2. SWEETNESS PERCEPTION......Page 100
3.1. GENERAL FEATURES OF HYDROGEN BONDING......Page 102
3.2. INFRARED SPECTROSCOPY AND HYDROGEN BONDING......Page 105
4. CO-CRYSTALS......Page 108
5. POLYMORPHISM......Page 111
6. MOLECULAR RECOGNITION IN SOLUTION  AND  CRYSTAL STRUCTURE......Page 115
7. CONFORMATIONAL RECOGNITION IN SOLUTION  AND CRYSTAL STRUCTURE......Page 119
8.1. CRYSTAL GROWTH IN THE PRESENCE OF TAYLOR-MADE ADDITIVES......Page 121
8.2. EFFECT OF THE SOLVENT ON THE CRYSTALLINE HABIT......Page 123
8.3. CONFORMATIONAL MIMICRY......Page 124
8.4. SEEDING CRYSTALLIZATION......Page 125
CONCLUDING REMARKS......Page 126
REFERENCES......Page 127
ABSTRACT......Page 133
INTRODUCTION......Page 134
INFRARED......Page 135
RAMAN......Page 136
AFM......Page 138
CHIRAL SURFACES AND THEIR INVESTIGATION BY STM AND AFM......Page 139
CHIRAL RECOGNITION AND IR AND SERS......Page 145
CHIRAL SURFACES AND OTHERS METHODS......Page 154
CONCLUSION......Page 160
REFERENCES......Page 161
1.1. GENERAL INTRODUCTION......Page 165
1.2. MOLECULAR IMPRINTING UNDERLYING PRINCIPLE......Page 166
1.3.1. COVALENT IMPRINTING......Page 167
1.3.2. NON-COVALENT IMPRINTING......Page 168
1.4.1. MONOMER SELECTION......Page 169
1.4.2.TEMPLATE, FUNCTIONAL MONOMER AND CROSS-LINKER  MOLAR RATIO......Page 170
I.4.3. ROLE OF CROSS-LINKERS......Page 171
1.5.5. RECOGNITION MEDIA AND PROGEN......Page 172
1.4.6. PH OF THE IMPRINTING SOLUTION......Page 173
1.4.7. PH OF THE REBINDING MIXTURE......Page 174
1.5.1. REBINDING EFFICIENCY AND TEMPLATE RECOVERY......Page 176
1.5.2. MOLECULAR SELECTIVITY OF THE IMPRINTED MATERIALS......Page 177
1.5.3. REPEATABILITY OF REBINDING PROCESS......Page 178
1.6.2. IMPRINTING IN INORGANIC MATERIALS......Page 179
1.7. COMPUTATIONAL APPROACHES TO MIPS......Page 181
1.8. THE POTENTIAL APPLICATIONS OF MOLECULARLY  IMPRINTED MATERIALS......Page 182
1.8.2. PREPARATION OF ANTIBODY ANALOGUES......Page 183
1.8.4. MOLECULARLY IMPRINTED MATERIALS FOR SENSORY APPLICATIONS......Page 184
REFERENCES......Page 185
ABSTRACT......Page 189
2. MONODENTATE INTERACTIONS AND BIDENTATE INTERACTIONS......Page 190
3. DNA-SMALL LIGAND MOLECULAR RECOGNITION  IN THE MINOR GROOVE......Page 193
4. DNA-LIGAND ALLOSTERIC INTERACTIONS......Page 195
6. DNA-PEPTIDE ALLOSTERIC INTERACTION NETWORKS......Page 205
REFERENCES......Page 207
ABSTRACT......Page 213
INTRODUCTION......Page 214
THREE DIMENSIONAL STRUCTURES AND BINDING SITES OF OBPS......Page 215
PH-DEPENDENT CONFORMATIONAL CHANGE AND LIGAND RELEASE IN OBPS......Page 216
BINDING PREFERENCE AND INITIAL RECOGNITION OF OBPS......Page 217
OBP/ODORANT COMPLEXES MAY ACT AS SIGNAL TRIGGERS......Page 219
CONCLUSION......Page 220
REFERENCES......Page 221
ABBREVIATIONS......Page 225
INTRODUCTION......Page 226
PEOPLE FROM THE PAST......Page 227
MEKLER......Page 228
BIRO......Page 229
BLALOCK-SMITH......Page 230
SIEMION......Page 231
THE PROTEOMIC CODE AND THE 3D STRUCTURE OF PROTEINS......Page 232
EXPERIMENTAL EVIDENCE......Page 233
CONTROVERSIES REGARDING THE ORIGINAL PROTEOMIC CODES......Page 236
DEVELOPMENT OF THE SECOND GENERATION PROTEOMIC CODE......Page 237
CONSTRUCTION OF A COMMON PERIODIC TABLE OF CODONS  AND AMINO ACIDS......Page 238
THE PHYSICO-CHEMICAL COMPATIBILITY OF AMINO ACIDS  IN THE PROTEOMIC CODE......Page 241
SEQX......Page 243
AMINO ACID SIZE, CHARGE, HYDROPATHY INDICES AND MATRICES FOR PROTEIN STRUCTURE ANALYSIS......Page 244
ANFINSEN’S THERMODYNAMIC PRINCIPLE AND THE PROTEOMIC CODE......Page 246
PROTEIN STRUCTURE AND THE FUNCTIONAL ASYMMETRY  OF THE CODONS......Page 247
COMPARISON OF THE PROTEIN AND MRNA SECONDARY STRUCTURES......Page 256
COMPLEMENTARY CODES VS AMINO ACID CO-LOCATIONS......Page 258
THEORY OF NUCLEIC ACID (CHAPERONS) ASSISTED PROTEIN FOLDING......Page 263
DEFINITION OF THE 2ND GENERATION PROTEOMIC CODE......Page 265
SYSTEM AND METHOD TO OBTAIN OLIGO-PEPTIDES WITH SPECIFIC HIGH AFFINITY TO QUERY PROTEINS......Page 272
EXAMPLE 1......Page 277
EXAMPLE 2. EXAMPLE FOR DESIGNING AND CHARACTERIZATION  OF A SPECIFIC PROTEIN–PROTEIN INTERACTION......Page 279
DEFINITIONS......Page 280
THE EXPERIMENT......Page 281
Scientific Potential......Page 283
THE VISION OF A PROTEOME-SENSOR CHIP......Page 284
THE VISION OF A NEW PHYSIOLOGY......Page 285
SOFTWARE......Page 286
REFERENCES......Page 287
REFERENCES TO TABLE I......Page 292
1. INTRODUCTION......Page 297
2.1. PREPARATION OF IMPRINTED POLYMERS......Page 299
2.4. SORPTION TEST......Page 300
3.1. FTIR AND SEM ANALYSIS OF MOLECULAR IMPRINTING......Page 301
3.2. SPECIFIC INTERACTION BETWEEN IMPRINTED POLYMERS AND SUBSTRATE......Page 303
3.3. PHASE TRANSITION BEHAVIOR......Page 304
3.4. SWITCHED MOLECULAR RECOGNITION......Page 305
3.5. TRACK OF KINETICS......Page 306
3.6. DYNAMIC BINDING BEHAVIOR......Page 308
ACKNOWLEDGMENTS......Page 309
REFERENCES......Page 310
INDEX......Page 311