Molecular and Cellular Pharmacology

Content: 
List of contributors
Pages xvii-xxv

Preface
Pages xxvii-xxviii
E. Edward Bittar, Neville Bittar

Chapter 1 Receptors: Topology, organization, and function Original Research Article
Pages 1-21
Michael Schachter

Chapter 2 Adrenergic and muscarinic cholinergic receptors Original Research Article
Pages 23-58
Claire M. Fraser, Norman H. Lee

Chapter 3 5-Hydroxytryptamine receptors Original Research Article
Pages 59-72
Stephen J. Peroutka, Tiffany A. Howell

Chapter 4 Dopamine receptors Original Research Article
Pages 73-94
Wouter J. Florijn, Frank I. Tarazi, Ian Creese

Chapter 5 GABAA receptors in the central nervous system Original Research Article
Pages 95-109
Leslie L. Devaud, F. Donelson Smith, A. Leslie Morrow

Chapter 6 Excitatory amino acid receptors Original Research Article
Pages 111-131
Roger Griffiths

Chapter 7 Substance P Original Research Article
Pages 133-139
Susan E. Leeman, Norman D. Boyd

Chapter 8 Pharmacology and molecular biology of opioid receptors Original Research Article
Pages 141-156
Hugh O. Pettit, Paul H.K. Lee, Kwen-Jen Chang

Chapter 9 Inositol 1,4,5-trisphosphate receptors Original Research Article
Pages 157-168
Colin W. Taylor

Chapter 10 The LDL receptor Original Research Article
Pages 169-188
Angeliki Georgopoulos

Chapter 11 Angiotensin II peptide hormone receptors: Structure/function correlates Original Research Article
Pages 189-211
Kathryn Sandberg, Hong Ji

Chapter 12 Melanocortin receptors Original Research Article
Pages 213-231
Kathleen G. Mountjoy

Chapter 13 Pharmacology in the critically III Original Research Article
Pages 233-251
L. Godsiff, G.R. Park

Chapter 14 Principles of drug metabolism Original Research Article
Pages 253-280
Jerome A. Roth

Chapter 15 Adrenergic drugs Original Research Article
Pages 281-311
A. Den Hertog

Chapter 16 Cholinergic Agents Original Research Article
Pages 313-321
Vijay C. Swamy

Chapter 17 Rational methods for site-directed drug design Original Research Article
Pages 323-343
Richard A. Lewis, Ann-Marie O'Neill

List of contributors
Pages xvii-xxv

Preface
Pages xxvii-xxviii
E. Edward Bittar, Neville Bittar

Chapter 18 The advantages of liposome-based gene therapy: A comparison of viral versus liposome-based gene delivery Original Research Article
Pages 345-362
Peter Hug, Richard G. Sleight

Chapter 19 The kallikrein-kinin-kininogen system Original Research Article
Pages 363-384
Donald H. Miller, Harry S. Margolius

Chapter 20 Cellular responses to eicosanoids: Molecular biology of eicosanoid receptors Original Research Article
Pages 385-405
Daniel J. O'Mahony, B. Therese Kinsella, Garret A. Fitzgerald

Chapter 21 Nitric oxide as a bioregulator Original Research Article
Pages 407-425
Philip K. Moore

Chapter 22 Medicinal Chemistry of steroids Original Research Article
Pages 427-463
F.J. Zeelen

Chapter 23 The influence of anabolic steroids on muscular strength Original Research Article
Pages 465-474
Glenn D. Braunstein

Chapter 24 Genomic pharmacology: From receptor internalization to nuclear translocation of third messengers Original Research Article
Pages 475-499
Pierre M. Laduron

Chapter 25 Cardiac glycosides Original Research Article
Pages 501-518
Hannes Todt, Harry A. Fozzard

Chapter 26 Antiarrhythmic drugs Original Research Article
Pages 519-527
Terence J. Campbell

Chapter 27 The tissue specificity of calcium antagonists Original Research Article
Pages 529-546
David J. Triggle

Chapter 28 Mode of action of angiotensin converting enzyme inhibitors Original Research Article
Pages 547-560
Louise M. Burrell, Paddy A. Phillips, Colin I. Johnston

Chapter 29 Mode of action of lipid-lowering drugs Original Research Article
Pages 561-575
Chris J. Packard, James Shepherd

Chapter 30 The physiologic basis of diuretic drug action and synergism Original Research Article
Pages 577-599
David H. Ellison

Chapter 31 Insulin and hypolycemic drugs Original Research Article
Pages 601-622
John A. Thomas, Michael J. Thomas

Chapter 32 Hypnotics and anti-anxiety agents Original Research Article
Pages 623-640
Arthur Raines

Chapter 33 Accurate diagnosis and drug selection in patients with chronic pain Original Research Article
Pages 641-654
Niels-Henrik Jensen, Per Sjøgren

Chapter 34 Leukotrienes Original Research Article
Pages 655-686
David S. Newcombe

Chapter 35 Anti-inflammatory drugs: Mechanisms of action Original Research Article
Pages 687-722
David S. Newcombe

List of contributors
Pages xvii-xxv

Preface
Pages xxvii-xxviii
E. Edward Bittar, Neville Bittar

Chapter 36 Treatment of gout and hyperuricemia Original Research Article
Pages 723-735
Alan N. Baer

Chapter 37 Idiosyncratic drug reactions Original Research Article
Pages 737-761
Munir Pirmohamed, B. Kevin Park

Chapter 38 Treatment of convulsive disorders Original Research Article
Pages 763-785
Brenda K. Colasanti

Chapter 39 General anesthetics Original Research Article
Pages 787-810
David J. Smith

Chapter 40 Cellular mechanisms of general anesthesia Original Research Article
Pages 811-828
K. Krnjević, E. Puil

Chapter 41 Alcohol and alcoholism Original Research Article
Pages 829-854
Peter K. Gessner

Chapter 42 The mode of action and metabolism of vitamin A Original Research Article
Pages 855-869
Jagannath Ganguly

Chapter 43 The vitamin A-binding proteins Original Research Article
Pages 871-882
George Wolf

Chapter 44 Biochemistry of the visual cycle Original Research Article
Pages 883-896
John C. Saari

Chapter 45 Vitamin B12 Original Research Article
Pages 897-917
Jenny P. Glusker

Chapter 46 Vitamin C Original Research Article
Pages 919-932
Harish Padh

Chapter 47 The prehormone vitamin D Original Research Article
Pages 933-949
Jan T. Dabek

Chapter 48 Vitamin E Original Research Article
Pages 951-963
T.K.K. Ha, M.E.J. Lean

Chapter 49 Vitamin K: Metabolic functions, mechanism of action, and human requirements Original Research Article
Pages 965-984
Lasse Uotila

Chapter 50 Selenium in nutrition and therapeutics Original Research Article
Pages 985-994
Jean Nève

Chapter 51 The dependence syndrome concept for alcohol and drug abuse Original Research Article
Pages 995-1002
Therese A. Kosten, Thomas R. Kosten

Chapter 52 Opioid tolerance and dependence Original Research Article
Pages 1003-1012
Stephen M. Johnson

Chapter 53 Activation mechanisms of chemical toxicity Original Research Article
Pages 1013-1032
Costas Ioannides

Chapter 54 Mechanisms of cell toxicity Original Research Article
Pages 1033-1049
James Kevin Chipman

Chapter 55 The blood-brain barrier as a protector against neurotoxic agents Original Research Article
Pages 1051-1063
Barbro B. Johansson

Chapter 56 Chelating agents as antidotes of metal poisoning Original Research Article
Pages 1065-1075
Mark M. Jones

Index
Pages 1077-1111