Mechanisms and Functions of Brain and Behavioural Asymmetries (Philosophical Transactions of the Royal Society series B)

Contents......Page 3
Mechanisms and functions of brain and behavioural asymmetries......Page 4
References......Page 7
Introduction......Page 9
Model......Page 10
Results......Page 11
Existence of partially lateralized populations......Page 12
References......Page 13
Introduction......Page 15
Handedness......Page 16
Cerebral and behavioural asymmetries......Page 17
Single-gene models......Page 18
Where is the gene?......Page 19
Why asymmetry?......Page 20
Why the variation in lateralization?......Page 21
Symmetrical oddity?......Page 22
References......Page 23
Hand preference assessment......Page 28
Geographical variation......Page 29
Genetic models of handedness......Page 30
Developmental factors......Page 31
Developmental instability in early foetal development......Page 32
Cultural influence......Page 33
Left-handedness as a costly trait......Page 34
Left-handedness as a beneficial trait......Page 35
References......Page 36
Introduction......Page 42
Auditory modality: lateralization of voice perception......Page 43
Visual modality: lateralization of face and gaze perception......Page 46
Visual modality: lateralization of biological motion perception......Page 50
Lateralization of the olfactory modality and pheromones......Page 51
Conclusions......Page 53
References......Page 54
Introduction......Page 62
The twin paradox......Page 63
Sex differences......Page 64
Experimental evidence......Page 65
Early development of handedness......Page 66
Asymmetric light input in birds......Page 67
Changes with age......Page 68
Evidence for other animal species......Page 69
Discussion......Page 70
References......Page 71
Introduction......Page 75
Literature search: keywords and selection criteria......Page 77
Direction of lateralization......Page 78
Humans......Page 83
Discussion......Page 85
References......Page 86
Introduction......Page 89
Sensory lateralization before hand/paw preferences......Page 90
Stability of hand preferences for simple reaching across the lifespan......Page 91
Response to novelty related to hand preference......Page 92
Hand preference and temperament or ‘personality’......Page 93
Stress hormone levels associated with hand preference......Page 94
Brain structure and hand preference......Page 95
References......Page 96
Birds as an asymmetry model......Page 101
Asymmetries of ascending, descending and commissural systems......Page 102
Testing the processing of unihemispheric information......Page 104
Asymmetric transfer of interhemispheric information and ascending systems......Page 105
Descending asymmetric modulation......Page 106
References......Page 107
Introduction......Page 110
Lateralization of response to ‘tidbitting’......Page 112
Passive avoidance learning......Page 113
Lateralization of fear responses (gaze cues)......Page 115
Lateralization of preference for face-like configurations......Page 116
Transitive inference learning......Page 118
Lateralization of social behaviours......Page 120
The effect of light and hormones on lateralization of social interactions......Page 121
References......Page 122
Introduction......Page 127
Material and methods......Page 128
Light fry......Page 129
Dark fry......Page 130
Functions of lateralization......Page 131
References......Page 132
Introduction......Page 134
Rationale and methodology for normalization of developmental time......Page 137
Laterality of epithalamic asymmetries and its correspondence to organ laterality......Page 138
Overall conservation of asymmetry in the parapineal-habenular-IPN system of teleosts......Page 139
Heterotopic parapineal efferent connectivity suggests divergent principles of development between zebrafish and medaka......Page 141
Is the laterality of asymmetry canalized in medaka?......Page 142
Conclusions: zebrafish and medaka as models for comparative developmental biology of vertebrate brain asymmetry......Page 143
References......Page 144
Medial habenula......Page 147
Lateral habenula......Page 148
Afferent connectivity......Page 149
Control of dopaminergic circuitry: motor activity and reward prediction......Page 150
Circadian rhythms......Page 151
Involvement in psychosis......Page 152
Size......Page 153
Pineal complex asymmetry......Page 154
Lateralization in circuit microarchitecture......Page 155
Nodal signalling specifies the laterality of neural asymmetry......Page 156
Symmetry breaking and the parapineal......Page 157
References......Page 158
Introduction......Page 163
The zebrafish as a model of epithalamic l-r asymmetry......Page 164
Epithalamic reversal does not affect motor responses......Page 165
Motor responses to directional stimuli......Page 166
Discussion......Page 167
Protocols for use of zebrafish were approved by the Institutional Animal Care and Use Committee of the Carnegie Institution Department of Embryology.......Page 171
References......Page 172