Magnesium and Pyridoxine: Fundamental Studies and Clinical Practice

MAGNESIUM AND PYRIDOXINE: FUNDAMENTAL STUDIESAND CLINICAL PRACTICE......Page 3
CONTENTS......Page 7
FOREWORD......Page 9
INTRODUCTION......Page 11
CLINICAL......Page 14
1.1. BACKGROUND......Page 17
1.2. EPIDEMIOLOGY......Page 19
1.3. BIOLOGICAL ROLES OF MAGNESIUM......Page 22
2. ABSORPTION, ELIMINATION AND THE DAILY REQUIREMENT OF MAGNESIUM......Page 35
3.1. ETIOLOGY OF MAGNESIUM DEFICIENCY......Page 39
3.2. PRIMARY AND SECONDARYMAGNESIUM DEFICIENCY......Page 41
3.3. CLINICAL SYMPTOMSOF MAGNESIUM DEFICIENCY......Page 42
3.4. CONSEQUENCES OF MAGNESIUM DEFICIENCY......Page 47
4. CONDITIONS AND DISEASES ACCOMPANIED BY MAGNESIUM DEFICIENCY......Page 49
4. 1. MAGNESIUM AND PREGNANCY......Page 51
4.1.1. Hypomagnesemia and condition of the fetus......Page 54
4.1.2. Glucose Tolerance, Metabolic Syndrome, Gestational Diabetes......Page 59
4.1.3. Recurrent Pregnancy Loss......Page 60
4.1.5. Hypermagnesemia in Pregnancy......Page 61
4.2. MAGNESIUM AND PYRIDOXINE IN PREMENSTRUAL SYNDROME; INFLUENCE OF THE STEROID-BASED DRUGS......Page 63
4.3.1. Neuromuscular Manifestations......Page 68
4.3.2. Stress, Chronic Fatigue Syndrome and Vegetative Dystonia......Page 69
4.3.3. Magnesium and Neurodegenerative Diseases......Page 73
4.3.4. Magnesium and Diseases of Dependence(Alcohol, Narcotic and Nicotine Dependence)......Page 74
4.4. MAGNESIUM AND CARDIOLOGY......Page 76
4.4.1. Molecular Effects of the Magnesiumon the Biochemistry of the Cardiac Tissue......Page 77
4.4.2. Magnesium and Myocardial Infarction (MI)......Page 82
4.4.3. Magnesium and Arrhythmia......Page 87
4.4.4. Magnesium and Arterial Hypertension......Page 90
4.4.5. Magnesium and Atherosclerosis......Page 93
4.4.6. Magnesium and Thrombus Formation......Page 94
Magnesium and Thromboxane Synthesis......Page 95
Magnesium and Coagulation......Page 97
4.5. MAGNESIUM AND UROLOGY......Page 100
4.6. MAGNESIUM AND DIABETES......Page 101
4.7.1. Undifferentiated Connective Tissue Dysplasias......Page 104
4.7.2. Magnesium and Molecular Cell Biology of the Connective Tissue......Page 105
4.7.3. Magnesium and Disorders of Skeletal System......Page 110
4.8. MAGNESIUM AND BRONCHIAL OBSTRUCTION......Page 112
4.9. MAGNESIUM AND PYRIDOXINE:IMMUNITY, ONCOLOGY AND TRANSPLANTATION......Page 113
4.10.1. Cadmium and Magnesium......Page 116
4.10.2. Beryllium and Magnesium......Page 117
4.10.4. Lead and Magnesium......Page 118
4.10.5. Nickel and Magnesium......Page 119
4.10.6. Radiation and Magnesium......Page 120
4.11. MAGNESIUM AND SPORTS......Page 121
5.1. MAGNESIUM DIET......Page 125
5.2. SOURCES OF MAGNESIUM IN THE ENVIRONMENT......Page 126
5.3. PHARMACOLOGICAL CORRECTION OF MAGNESIUM DEFICIENCY......Page 127
5.5. MAGNESIUM-PRESERVING DIURETICS......Page 130
5.6. MAGNESIUM FIXATION......Page 131
6.1. PARTIAL MAGNESIUM ANALOGUES......Page 133
6.3. MAGNESIUM-DEPLETING DRUGS......Page 134
7. TOXICOLOGY OF MAGNESIUM: HYPERMAGNESEMIA......Page 135
8.1. METABOLISM, ABSORPTION AND ELIMINATION OF PYRIDOXINE......Page 139
8.2. PYRIDOXINE DEFICIENCY......Page 140
8.3. DIETARY PYRIDOXINE REQUIREMENTS......Page 144
8.4. TREATMENT OF PYRIDOXINE DEFICIENCY......Page 145
9.1. THE MAJOR METHODS FOR DETERMINATIONOF THE MAGNESIUM DEFICIENCY......Page 149
9.3. DETERMINATION OF PYRIDOXINE......Page 151
CONCLUSION......Page 153
APPENDIX I. THE CONTENTS OF MINERAL SUBSTANCES AND PYRIDOXINE IN DIFFERENT FOODS......Page 155
APPENDIX II. REFERENCE VALUES OF MINERAL AND TRIGLYCERIDE LEVELS (GROMOVA, 2001)......Page 157
APPENDIX III. TESTING GLYCOSYLATED HEMOGLOBIN-C (HBA1C)......Page 161
APPENDIX IV. GENES IMPLICATED IN MAGNESIUM HOMEOSTASIS......Page 163
APPENDIX V. POLYMORPHISMS ASSOCIATED WITH CONNECTIVE TISSUE DISPLASIAS (CTD)......Page 165
INDICATIONS......Page 167
SPECIAL PRECAUTIONS......Page 168
OVERDOSE......Page 169
REFERENCES......Page 171
INDEX......Page 191