Lipid Mediators in the Immunology of Shock

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Burns and Sepsis: Immunological Overview....Pages 3-20
Burns: Clinical and Biological Overview....Pages 21-30
Infection: Cause or Effect of Pathophysiologic Change in Burn and Trauma patients....Pages 31-42
Biochemical Mediators in Acute Respiratory Distress Syndrome (ARDS) after Burning Injury....Pages 43-55
“Sepsis Parameters” in Patients with Lethal Burn....Pages 57-61
Computer Assisted 10 MHZ Sonography of Burn Depth in Man - a Quantitative Guide for the Surgical Strategy of Sepsis Prevention....Pages 63-66
Pharmacological Control of Hemorrhagic Shock : Does Hypertonic Resuscitation Qualify?....Pages 67-76
Front Matter....Pages 77-77
Oxygen, Free Radicals, Shock and Trauma....Pages 79-86
Role of Free Radical Lipid Peroxidation in Burn and Endotoxin Shock....Pages 87-95
The Significance of Pentane Measurements in Man....Pages 97-102
Detection of Pentane as a Measurement of Lipid Peroxidation in Humans Using Gas Chromatography With a Photoionization Detector....Pages 103-108
Eicosanoids and The Pathophysiology of Sepsis and Trauma....Pages 109-123
Lipid Metabolism during Starvation and Sepsis in Relation to Fatty Acid Profile in Liver and α-Linolenic- and γ-Linolenic Acid-Enriched Diets....Pages 125-128
Pathophysiology of Renal Failure in Shock: Role of Lipid Mediators....Pages 129-137
Multiple Organ Failure, Liver Failure and Polyunsaturated Fat Metabolism....Pages 139-150
Leukotrienes in Endotoxin Shock....Pages 151-158
Time-Dependent Appearance of LTB 4 in Human Burn Blisters....Pages 159-162
Platelet-Activating Factor: An Inflammatory Mediator Involved in the Pathophysiology of Shock....Pages 163-176
Mechanisms of Circulatory Collapse Induced by PAF-Acether....Pages 177-185
Lipid Mediators in Lung Anaphylaxis: Kinetics of Their Release and Modulation by Selected Drugs....Pages 187-196
Front Matter....Pages 77-77
A Role For Platelet Activating Factor In Shock And Acute Lung Injury....Pages 197-207
Morphological and Pharmacological Evidences for the Participation of PAF-Acether in Anaphylactic Shock in the Guinea-Pig....Pages 209-215
Biogenic Amines: Microcirculatory Aspects in Shock, Sepsis and Trauma....Pages 217-226
Trypsin-like Activity in Burn and Sepsis....Pages 227-235
Significance of the Activation of the Kinin System Following Thermal Injury....Pages 237-240
The Role of Lipid Mediators in Blood Fibrinolysis....Pages 241-248
Fibrinolysis in Endotoxemia....Pages 249-254
Front Matter....Pages 255-255
Origins of Immunological Impairments in Burns....Pages 257-264
Importance of Immune Function in Trauma for Survival....Pages 265-275
Anergy in Critically Ill Patients....Pages 277-283
Neural Release Mechanisms of the Injury Response....Pages 285-288
Surgery and the Immune Response....Pages 289-303
Immune Function and Severe Infection....Pages 305-307
Front Matter....Pages 309-309
Interleukins: An Overview....Pages 311-319
Cellular Immune Function and Injury....Pages 321-328
Metabolic Mediators in Injury....Pages 329-335
Mediators Affecting IL 2 Function in Burn Immunosuppression....Pages 337-347
T Cell Subpopulations Following Thermal Injury Effect of the Acute Stress Response....Pages 349-360
Natural Killer Cell Activity and Lymphocyte Function During and after Open-Heart Surgery in Relation to the Endocrine Stress Response....Pages 361-364
Natural Killer Cell Activity during Epinephrine and Cortisol Infusion in Healthy Volunteers....Pages 365-368
Front Matter....Pages 309-309
A Longitudinal Study of the Influence of Acute Myocardial Infarction on Natural Killer Cells....Pages 369-371
Immune Depression and Sepsis Following Injury: The Role and Identity of Circulating Mediators....Pages 373-381
Elective Immunosuppression....Pages 383-393
Characterization of the Induction of Human Interleukin 1 by Endotoxins....Pages 395-407
Human Endothelial Cells Produce Platelet Activating Factor in Response to Interleukin 1....Pages 409-416
Interleukin-1 Stimulation of Vascular Endothelial Cell Adhesiveness for Leucocytes: In Vitro And In Vivo Studies....Pages 417-427
Systemic Alteration of Endothelial Cells in Shock....Pages 429-435
Arterial Wall Reaction Following Electrical Local De-Endothelialization....Pages 437-444
Front Matter....Pages 445-445
The Role of Platelet Activating Factor in the Immune Response....Pages 447-458
Leukotrienes in Lymphocyte Activation: Leukotriene B 4 Enhances Interleukin 2 and Interferon-Gamma Production by Mitogen and Alloantigen-Stimulated Human T Cells....Pages 459-468
Regulation of T-Cell Activation by Leukotriene B 4 ....Pages 469-481
A Role for Platelet-Activating Factor (PAF) in Human T-Lymphocyte Proliferation....Pages 483-493
Front Matter....Pages 495-495
Lack of Effect of Cyclosporine a on Endogenous Arachidonic Acid Metabolism in Human Neutrophils....Pages 497-499
Sulotroban (BM 13.177) and BM 13.505, Two TX-Receptor Blockers, are Effective in Experimental Models of Ischaemia and Shock....Pages 501-505
Ginkgo Biloba Extracts Inhibits Oxygen Species Production Generated by Phorbol Myristate Acetate Stimulated Human Leukocytes....Pages 507-511
The Coronary, Inotropic, Chronotropic and Arrhythmogenic Effects of Paf-Acether on Isolated Guinea-Pig Heart and their Selective Inhibition by BN 52021....Pages 513-517
The Effect of BW 755C on Wound Healing in a Scald Burn Injury Pig Model-Morphological and Biochemical Findings....Pages 519-522
A New Sonographic Model for Effective Quantification of Antiedematous And AntiInflammatory Drugs in Burns....Pages 523-526
Back Matter....Pages 527-530