Investigation and Exploitation of Antibody Combining Sites

Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Antibody Combining Sites — Past, Present and Future....Pages 3-22
Variability, Modelling and Prediction of β-Hairpins with Reference to the Immunoglobulin Fold....Pages 23-31
Probing the Binding Sites in Crystals of Immunoglobulins....Pages 33-50
Comparative Structures of Mouse Antibody Combining Sites....Pages 51-60
An Approach to the Study of Anti-Protein Antibody Combining Sites....Pages 63-68
Front Matter....Pages 73-73
Investigating the Specificity of Monoclonal Antibodies to Protein Antigens Using β-Galactosidase Fusion Proteins....Pages 75-82
Antibody-Screening cDNA Libraries....Pages 83-90
Anti-Receptor Antibodies by the Auto-Anti-Idiotypic Route....Pages 91-107
Production and Characterization of Anti-Morphine Anti-Idiotypic Antibodies....Pages 109-114
Anti-Idiotype Antibodies for the Study of Membrane Receptors: The Double Monoclonal Antibody Approach....Pages 115-122
Characterization of Idiotypes and V H Genes of Various Members of A48-Idiotypic Network Pathway....Pages 125-126
Monoclonal Internal Image Anti-Idiotypic Antibodies of Hepatitis B Surface Antigen....Pages 127-128
Structure and Expression of Genes Encoding IgA Heavy Chains....Pages 129-130
Human:Mouse Antibody-Producing Transfectoma Cell Lines....Pages 131-132
Different Ways to Modify Monoclonal Antibodies....Pages 133-138
Restructuring Enzymes and Antibodies....Pages 139-140
Dideoxy mRNA Sequencing as a Method to Analyze Antibody Diversity....Pages 141-142
Effect of Multivalent Binding on Dissociation of Monoclonal Antibodies from Cell Surface Antigens....Pages 143-143
Front Matter....Pages 151-151
Immunological Approaches and Techniques Employed in Tubulin and Microtubule Research....Pages 153-166
Cell-Surface Events during Myogenesis: Immunofluorescence Analysis using Monoclonal Antibodies....Pages 167-176
Front Matter....Pages 151-151
Differential Expression of Cell-Surface Antigens on Muscle Satellite Cells and Myoblasts....Pages 177-188
Cholinergic-Specific Nerve Terminal Antigens....Pages 189-206
Use of Antibodies to Purify Cholinergic Nerve Terminals....Pages 207-214
An Immunological Approach to the Cell Lineage Problem in the Mammalian CNS....Pages 217-218
An Enzyme-Linked Immunosorbent Assay for Calmodulin....Pages 219-222
Intermediate Filament Diversity as Detected by Antibodies....Pages 223-226
Front Matter....Pages 229-229
Exploitation of Antibodies in the Study of Cell Membranes....Pages 231-246
Use of Polyclonal and Monoclonal Antibodies in Studying Complement Component C9 as a Trans-Membrane Protein....Pages 247-253
Ca 2+ -Binding Proteins Located on the Cytoplasmic Face of the Lymphocyte Plasma Membrane....Pages 255-265
The T-Cell Receptor....Pages 267-274
New Light on the T-Cell Receptor in Relation to Antibody Binding Sites....Pages 277-278
Molecular Nature of the T3 Antigen of Human T Lymphocytes....Pages 279-280
Organization and Expression of the Murine T-Cell Receptor β-Chain Gene Complex....Pages 281-282
Antigen-Specific T-Cell Activation....Pages 283-286
Front Matter....Pages 291-291
Requirements by Cancer Cells for Polypeptide Growth Factors Suggest New Therapeutic Strategies....Pages 293-298
Monoclonal Antibodies to Human Tumours for Targeting Cytotoxic Drugs....Pages 299-305
Antigenic Modulation as a Limiting Factor in the Treatment of B-Cell Lymphoma with Anti-Idiotype Antibody....Pages 307-315
Tumour-Associated Carbohydrate Antigens of Glycoproteins....Pages 317-322
Glycolipid Antigens: Potential in Cancer Detection and Diagnosis....Pages 323-332
Immune Surveillance....Pages 335-335
Front Matter....Pages 291-291
Workshop Discussion focused on #E-4, #E-5 & #E-3....Pages 337-340
Guidance for ‘Uninitiated’ Readers....Pages 345-348
Back Matter....Pages 349-359