interactions of transmembrane peptides and proteins with lipid membranes

Jeroen Adrianus Antonius Demmers......Page 3
Prof. dr. J. A. Killian......Page 4
Aan mijn ouders......Page 5
Dw.pdf......Page 0
Dankwoord134......Page 7
General introduction......Page 9
Building blocks of membranes......Page 11
Integral membrane proteins......Page 13
Three-dimensional structures of integral membrane proteins in detail......Page 15
Structural characteristics of membrane-spanning (-helices......Page 16
Structural characteristics of membrane spanning domains in the membrane-water interfacial region......Page 18
In Chapter 4, I shall move from biophysical chemistry towards a physical chemistry related subject, which is about possible complications in H/D exchange studies that might result from gas-phase migration of deuterium atoms incorporated in the peptides......Page 30
In Chapter 6, the results presented in this thesis are summarized and discussed in the context of the present literature.......Page 31
Introduction......Page 43
Introduction......Page 59
Introduction......Page 79
Summarizing discussion......Page 109
Global hydrogen/deuterium exchange kinetics and mass spectrometry in studying peptide-membrane interactions......Page 111
General remarks on H/D exchange combined with nano-flow ESI-MS......Page 114
Dependence of exchange kinetics in membrane-associated peptides on the lipid environment......Page 119
Non-covalent interactions in a membrane environment......Page 120
Nederlandse samenvatting......Page 127
Curriculum vitae......Page 132
List of publications......Page 133
Dankwoord......Page 134