Inflammatory Bowel Disease: From Bench to Bedside

Front Matter....Pages 1-1
Introduction: Inflammatory bowel disease: from bench to bedside....Pages 3-4
The changing faces of Crohn’s disease and ulcerative colitis....Pages 5-20
Genetics of inflammatory bowel disease....Pages 21-65
Experimental mouse models of inflammatory bowel disease: new insights into pathogenic mechanisms....Pages 67-99
The normal intestinal mucosa: a state of ‘controlled inflammation’....Pages 101-120
The lymphocyte-epithelial-bacterial interface....Pages 121-146
The mucosal inflammatory response. Cytokines and chemokines....Pages 147-176
Role of the microcirculation in chronic gut inflammation....Pages 177-196
Remission, relapse, intestinal healing and repair....Pages 197-209
Antibodies in the exploration of inflammatory bowel disease pathogenesis and disease stratification....Pages 211-222
Pathophysiology of inflammatory bowel disease: the effect of inflammation on intestinal function....Pages 223-234
Systemic consequences of intestinal inflammation....Pages 235-250
Front Matter....Pages 251-251
Understanding symptoms and signs in inflammatory bowel disease....Pages 253-267
Clinical course and complications of ulcerative colitis and ulcerative proctitis....Pages 269-290
Clinical features and complications of Crohn’s disease....Pages 291-304
Mechanisms of systemic inflammation associated with intestinal injury....Pages 305-335
Pathology of inflammatory bowel disease: a critical appraisal in diagnosis and management....Pages 337-355
An endoscopic and histologic perspective of diagnosis: when, where, and what to do....Pages 357-370
Radiologic (radiographic) and imaging features of ulcerative colitis and Crohn’s disease....Pages 371-407
New diagnostic approaches in inflammatory bowel disease....Pages 409-429
Front Matter....Pages 251-251
Differential diagnosis of colitis....Pages 431-455
‘Disease management’ in chronic medical conditions....Pages 457-470
Pharmacoeconomics and inflammatory bowel disease....Pages 471-480
Measuring quality of life in inflammatory bowel disease....Pages 481-494
Clinical pharmacology in inflammatory bowel disease: optimizing current medical therapy....Pages 495-521
Multi-site therapeutic modalities for inflammatory bowel diseases — mechanisms of action....Pages 523-551
Targeted therapies for inflammatory bowel disease....Pages 553-571
Role of antibiotics and probiotics in the management of inflammatory bowel disease....Pages 573-585
Nutrition in inflammatory bowel disease....Pages 587-604
Medical management of ulcerative colitis....Pages 605-629
Surgical management of ulcerative colitis....Pages 631-641
Pouchitis: clinical characteristics and management....Pages 643-658
Medical therapy for Crohn’s disease....Pages 659-680
Surgery for Crohn’s disease....Pages 681-696
Postoperative prevention of recurrence of Crohn’s disease....Pages 697-709
The molecular pathology of inflammatory bowel disease-associated neoplasia and preneoplasia....Pages 711-718
Dysplasia in inflammatory bowel disease: clinical pathology and current surveillance methods....Pages 719-729
Hepatobiliary disorders....Pages 731-745
Articular and ocular complications of inflammatory bowel disease....Pages 747-756
Cutaneous manifestations of inflammatory bowel disease....Pages 757-762
Front Matter....Pages 251-251
Fertility and pregnancy in inflammatory bowel disease....Pages 763-771
Special considerations in the diagnosis and management of inflammatory bowel disease in the pediatric age group....Pages 773-790
Microscopic colitis: collagenous and lymphocytic colitis....Pages 791-798
Colon ischemia....Pages 799-810
Diversion colitis....Pages 811-821
Pseudomembranous colitis and Clostridium difficile infection....Pages 823-844
Infectious colitis....Pages 845-861
Human Immunodeficiency virus and inflammatory bowel disease....Pages 863-873
Bone metabolism and inflammatory bowel disease....Pages 875-883
Front Matter....Pages 885-885
Epilogue: Bench to bedside and back to bench....Pages 887-891