Helicobacter pylori: Basic Mechanisms to Clinical Cure

Front Matter....Pages i-xix
Front Matter....Pages 1-1
 In vivo models of gastric Helicobacter infections....Pages 3-27
 H. pylori species heterogeneity....Pages 28-40
 H. pylori urease....Pages 41-58
Basic bacteriology of H. pylori : H. pylori colonization factors....Pages 59-72
Front Matter....Pages 73-73
Epidemiology of H. pylori in Western countries....Pages 75-84
 H. pylori in developing countries....Pages 85-94
Prevalence/disease correlates of H. pylori ....Pages 95-112
Reinfection with H. pylori ....Pages 113-120
Front Matter....Pages 121-121
Breakdown of the mucus layer by H. pylori ....Pages 123-138
Decreased hydrophobicity of gastroduodenal mucosa due to H. pylori infection in humans....Pages 139-147
Adherence and internalization of H. pylori by epithelial cells....Pages 148-162
Mechanisms of ammonia-induced gastric mucosal injury: role of glutathione and cysteine proteases....Pages 163-168
Lipopolysaccharide (LPS)-related damage by H. pylori ....Pages 169-179
The cpn60 heat shock protein homologue of H. pylori ....Pages 180-187
Gastric mucosal injury: interactions of mast cells, cytokines and nitric oxide....Pages 188-197
 H. pylori supernatant contains a novel chemotactic factor for monocytes different from FMLP....Pages 198-206
 H. pylori -induced neutrophil activation and production of toxic oxygen radicals....Pages 207-213
Polymorphonuclear leukocytes traffic into the gastric mucosa and through the gastric mucosal barrier in H. pylori infection: is that bad?....Pages 214-221
 H. pylori vacuolating toxin....Pages 222-231
 H. pylori alcohol dehydrogenase....Pages 232-242
Front Matter....Pages 243-243
Effect of H. pylori infection on gastrin and gastric acid secretion....Pages 245-256
 H. pylori , gastrin and somatostatin....Pages 257-266
Parietal cell responsiveness in H. pylori infections....Pages 267-272
Role of bacterial amines in H. pylori -associated hypergastrinaemia....Pages 273-280
Do gastric mucosal nerves remodel in H. pylori gastritis?....Pages 281-291
Front Matter....Pages 293-293
Overview of the immune response to H. pylori ....Pages 295-305
Specific H. pylori immune response....Pages 306-308
B cell responses in H. pylori infection....Pages 309-320
T cell subsets in H. pylori -associated gastritis....Pages 321-332
Down-regulation of the immune response to H. pylori ....Pages 333-341
The clinical value of a saliva diagnostic assay for antibody to H. pylori ....Pages 342-350
Front Matter....Pages 351-351
Spectrum and implications of inflammation with H. pylori ....Pages 353-361
‘Hypertrophic’ gastritis in H. pylori infection....Pages 362-371
Long-term consequences of H. pylori infection: time trends in H. pylori gastritis, gastric cancer and peptic ulcer disease....Pages 372-380
Determinants of gastritis phenotype in H. pylori infection....Pages 381-389
The ulcer-associated cell lineage (UACL); a newly recognized pathway of gastrointestinal differentiation of importance in the natural healing of peptic ulcer disease....Pages 390-404
Front Matter....Pages 405-405
Acute infection with H. pylori ....Pages 407-412
 H. pylori in asymptomatic people....Pages 413-420
Determinants of clinical outcome of H. pylori infection: duodenal ulcer....Pages 421-428
 H. pylori and gastric ulcer disease....Pages 429-436
Front Matter....Pages 405-405
Functional dyspepsia and H. pylori : a controversial link....Pages 437-448
 H. pylori and NSAIDs: a meta-analysis on interactions of acute gastroduodenal injury, gastric and duodenal ulcers and upper gastrointestinal symptoms....Pages 449-457
Front Matter....Pages 459-459
 H. pylori and gastric cancer: the significance of the problem....Pages 461-468
The ascorbic acid story....Pages 469-474
Role of bacterial overgrowth in gastric carcinogenesis....Pages 475-482
The role of PCR techniques in the epidemiology of H. pylori infections....Pages 483-489
Role of H. pylori in atrophic gastritis and intestinal metaplasia....Pages 490-497
 H. pylori -associated gastric lymphoma....Pages 498-503
Animal models for Helicobacter -induced gastric and hepatic cancer....Pages 504-522
Flaws in H. pylori -related carcinogenesis hypothesis....Pages 523-528
Front Matter....Pages 529-529
Determinants of antimicrobial effectiveness in H. pylori gastritis....Pages 531-537
Mucosal antibiotic levels....Pages 538-549
 H. pylori eradication....Pages 550-569
 H. pylori resistance to antibiotics....Pages 570-583
The role of acid suppression in the treatment of H. pylori infection....Pages 584-592
Prospects for vaccination against H. pylori infection....Pages 593-599
Back Matter....Pages 601-612