Guanidines: Historical, Biological, Biochemical, and Clinical Aspects of the Naturally Occurring Guanidino Compounds

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
New High-Speed Fully Automated Guanidino Compound Analyzer....Pages 3-13
Automatic Guanidine Analyzer Using Benzoin as a Fluorogenic Reagent....Pages 15-31
Simple Methods for the Determination of Methylguanidine and Guanidinosuccinic Acid in Biological Fluids....Pages 33-38
Enzymic Determination of Methylguanidine in Urine....Pages 39-46
Front Matter....Pages 47-47
Developmental Changes in Guanidino Compounds Levels in Mouse Organs....Pages 49-58
Developmental Changes of Guanidino Compounds in Chick Embryo....Pages 59-69
Metabolism of L-[Amidino- 15 N]-Arginine to Guanidino Compounds....Pages 71-81
Biosynthesis of Guanidinoacetic Acid in Isolated Rat Hepatocytes....Pages 83-92
Biosynthesis of Guanidinosuccinic Acid in Isolated Rat Hepatocytes: Evaluation of Guanidine Cycle and Acidosis....Pages 93-103
The Role of the Liver as a Significant Modulator of the Serum Guanidinoacetic Acid Level in Man....Pages 105-112
Conversion of Urea Nitrogen into Protein Nitrogen by a Freshwater Fish, Sarotherodon Mossambicus ....Pages 113-118
Topographical Distribution of Sheep Brain Arginase: Its Response to Some Guanidino Compounds....Pages 119-124
The Effect of Sodium Valproate on Blood Ammonia Levels and the Concentrations of Guanidino Compounds in Mouse Tissue....Pages 125-133
The Guanidine Cycle....Pages 135-144
Arginine Utilization in Muscle and Kidney of Frog during Ammonotoxemia....Pages 145-148
Arginine Metabolism in Citrullinemic Patients....Pages 149-158
Studies on the Occurrence of Guanidino Compounds in Serum and Urine of Patients with Epilepsy, Neuronal Ceroid-Lipofuscinosis and Uremic Patients....Pages 159-169
Determination of Guanidino Compounds in Plasma and Urine of Patients with Argininemia before and during Therapy....Pages 171-180
Hyperargininemia: Treatment with Sodium Benzoate and Phenylacetic Acid....Pages 181-193
Front Matter....Pages 195-195
Effect of Methylguanidine on Muscle Protein Synthesis....Pages 197-204
Front Matter....Pages 195-195
Effect of Methylguanidine on Erythrocyte Membranes....Pages 205-212
Taurine and the Actions of Guanidinoethane Sulfonate....Pages 213-225
Effects of Guanidinoethane Sulfonate and Taurine on Electroshock Seizures in Mice....Pages 227-234
Effect of Taurine, Taurocyamine and Anticonvulsants on Dibenzoylguanidine-Induced Convulsions and their Relation to Brain Monoamine Levels in ddY and El Mice....Pages 235-247
Effect of Chronic Alcohol Administration on the Concentrations of Guanidino Compounds in Rat Organs....Pages 249-261
Front Matter....Pages 263-263
Guandino Compounds: Implications in Uremia....Pages 265-275
A Study of Creatine Metabolism in Chronic Renal Failure Rats....Pages 277-285
Guanidino Compounds in Patients with Acute Renal Failure....Pages 287-294
Possibility of a Common Metabolic Pathway for the Production of Methylguanidine and Dimethylamine in Chronic Renal Failure....Pages 295-308
Guanidinoacetic Acid (GAA) in Patients with Chronic Renal Failure (CRF) and Diabetes Mellitus (DM)....Pages 309-316
Metabolic Changes of Guanidino Compounds in Acute Renal Failure Complicated with Hepatic Disease....Pages 317-325
Urinary Guanidinoacetic Acid Excretion in Gentamicin Nephrotoxicity....Pages 327-334
The Importance of Energy Intake for Preventing the Accumulation of Guanidino Compounds in Patients with Chronic Renal Failure....Pages 335-341
The Effect of Lactulose on the Metabolism of Guanidino Compounds in Chronic Renal Failure....Pages 343-351
Evaluation of the Efficacy of Anti-Rejection Therapy Using the Quantitative Analysis of Guanidinoacetic Acid (GAA) Urinary Excretion as a Guide....Pages 353-363
Metabolic Profiles of Guanidino Compounds in Various Tissues of Uremic Rats....Pages 365-372
Guanidinoacetic Acid (GAA) Deficiency and Supplementation in Rats with Chronic Renal Failure (CRF)....Pages 373-379
Front Matter....Pages 381-381
Natural Guanidino Compounds....Pages 383-438
Back Matter....Pages 439-479