Glycosaminoglycans in Development, Health and Disease

Content: 
Copyright
Page iv

Contributors
Pages xiii-xv

Preface
Pages xvii-xviii
Lijuan Zhang

Glycosaminoglycan (GAG) Biosynthesis and GAG-Binding Proteins
Pages 1-17
Lijuan Zhang

Mice Deficient in Glucuronyltransferase-I
Pages 19-34
Tomomi Izumikawa, Hiroshi Kitagawa

Mice Deficient in Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1
Pages 35-58
Maria Ringvall, Lena Kjellén

Glucuronyl C5-Epimerase: An Enzyme Converting Glucuronic Acid to Iduronic Acid in Heparan Sulfate/Heparin Biosynthesis
Pages 59-78
Jin-ping Li

Mice Deficient in Heparan Sulfate 6-O-Sulfotransferase-1
Pages 79-111
Hiroko Habuchi, Koji Kimata

The Roles of Chondroitin-4-Sulfotransferase-1 in Development and Disease
Pages 113-132
Michael Klüppel

Roles of Heparan Sulfate in Mammalian Brain Development: Current Views Based on the Findings from Ext1 Conditional Knockout Studies
Pages 133-152
Yu Yamaguchi, Masaru Inatani, Yoshihiro Matsumoto, Junko Ogawa, Fumitoshi Irie

Anticoagulant Heparan Sulfate: To Not Clot—Or Not?
Pages 153-178
Nicholas W. Shworak, Takashi Kobayashi, Ariane de Agostini, Nicole C. Smits

Endothelial Heparan Sulfate in Angiogenesis
Pages 179-212
Mark M. Fuster, Lianchun Wang

Hepatic Heparan Sulfate Proteoglycans and Endocytic Clearance of Triglyceride-Rich Lipoproteins
Pages 213-233
Erin M. Foley, Jeffrey D. Esko

Serglycin Proteoglycan Deletion in Mouse Platelets: Physiological Effects and Their Implications for Platelet Contributions to Thrombosis, Inflammation, Atherosclerosis, and Metastasis
Pages 235-287
Barbara P. Schick

Congenital Disorders of Glycosylation with Emphasis on loss of Dermatan-4-Sulfotransferase
Pages 289-307
Lijuan Zhang, Thomas Müller, Jacques U. Baenziger, Andreas R. Janecke

Heparan Sulfate Proteoglycans in Amyloidosis
Pages 309-334
Xiao Zhang, Jin-Ping Li

Heparin as an Inhibitor of Cancer Progression
Pages 335-349
Lubor Borsig

Vascular Dermatan Sulfate and Heparin Cofactor II
Pages 351-372
Douglas M. Tollefsen

Diverse Functions of Glycosaminoglycans in Infectious Diseases
Pages 373-394
Rafael S. Aquino, Eui Seung Lee, Pyong Woo Park

Molecular Mechanism Underlines Heparin-Induced Thrombocytopenia and Thrombosis
Pages 395-421
Yi Qian, Jing Pan, Xiaodong Zhou, Peter Weiser, Hong Lu, Lijuan Zhang

Chondroitin Sulfate and Abnormal Contact System in Rheumatoid Arthritis
Pages 423-442
Xiaodong Zhou, Peter Weiser, Jing Pan, Yi Qian, Hong Lu, Lijuan Zhang

Activated Contact System and Abnormal Glycosaminoglycans in Lupus and other Auto- and Non-Autoimmune Diseases
Pages 443-472
Peter Weiser, Yi Qian, Jing Pan, Xiaodong Zhou, Hong Lu, Daniel R. Studelska, Fei F. Shih, Lijuan Zhang

Glycosaminoglycans and Activated Contact System in Cancer Patient Plasmas
Pages 473-495
Jing Pan, Yi Qian, Peter Weiser, Xiaodong Zhou, Hong Lu, Daniel R. Studelska, Lijuan Zhang

Index
Pages 497-510