Glutathione

Content: ContentsSeries Preface.............................................................................................................xiEditor\'s Preface....................................................................................................... xiiiEditor Biography......................................................................................................xixList of Contributors .................................................................................................xxiPart I Biosynthesis, Compartmentation,and Transport of GlutathioneChapter 1 Biosynthesis of Glutathione and Its Regulation....................................3Henry J. Forman, Hongqiao Zhang, and Terrance J. KavanaghChapter 2 Renal Glutathione Transport Systems: Roles in RedoxHomeostasis, Cytoprotection, and Bioactivation................................ 35Lawrence H. LashPart II Glutathione-DependentHydroperoxide MetabolismChapter 3 The Catalytic Mechanism of Glutathione Peroxidases....................... 53Laura Orian, Giorgio Cozza, Matilde Maiorino, StefanoToppo, and Fulvio UrsiniChapter 4 GPx1-Dependent Regulatory Processes in Health and Disease......... 67Diane E. Handy and Joseph LoscalzoChapter 5 Glutathione Peroxidase 1 as a Modulator of Insulin Productionand Signaling: Implications for Its Dual Role in Diabetes................. 81Holger Steinbrenner and Lars-Oliver KlotzChapter 6 GPx2 Role in Physiology and Carcinogenesis....................................95Anna P. KippChapter 7 GPx4: From Prevention of Lipid Peroxidation toSpermatogenesis and Back................................................................ 111Matilde Maiorino, Antonella Roveri, and Fulvio UrsiniChapter 8 Thiols, Glutathione, GPx4, and Lipid Metabolism at theCrossroads of Cell Death and Survival............................................. 129Jose Pedro Friedmann Angeli, Valerian E. Kagan, and MarcusConradChapter 9 Peroxiredoxin 6 as Glutathione Peroxidase...................................... 143Yefim ManevichChapter 10 Glutathione Peroxidases and the Thyroid Gland.............................. 161Lutz SchomburgPart III Conjugations and IsomerizationsChapter 11 Glutathione Transferases: From the Test Tube to the Cell................ 175Bengt Mannervik and Birgitta SjoedinChapter 12 Protein S-Glutathionylation and Glutathione S-Transferase P.......... 201Kenneth D. TewChapter 13 The Role of Glutathione in Biosynthetic Pathways andRegulation of the Eicosanoid Metabolism........................................ 215Ralf Morgenstern, Leopold Flohe, Jesper Z. Haeggstroem, andPer-Johan JakobssonChapter 14 Nitric Oxide and S-Nitrosoglutathione..............................................227Iain L. O. Buxton and Scott D. BarnettPart IV The GlutaredoxinsChapter 15 The Catalytic Mechanism of Glutaredoxins..................................... 251Linda Liedgens and Marcel DeponteChapter 16 The Role of Glutaredoxins in the Brain............................................263Carsten Berndt, Anna Dorothee Engelke, Klaudia Lepka, andLars BrautigamPart V Glutathione Derivatives andSubstitutes in Pathogenic MicroorganismsChapter 17 Biosynthesis of Polyamine Glutathione Derivatives inEnterobacteria and Kinetoplastida...................................................285Marcelo A. CominiChapter 18 Trypanothione Functions in Kinetoplastida......................................307Martin Hugo, Madia Trujillo, Lucia Piacenza, and Rafael RadiChapter 19 Mycothiol, a Low-Molecular-Weight Thiol Drafted forOxidative Stress Defense Duty......................................................... 331Leonardo Astolfi Rosado, Brandan Pedre, and Joris MessensChapter 20 Biosynthesis and Functions of Bacillithiol in Firmicutes................. 357Quach Ngoc Tung, Nico Linzner, Vu Van Loi,and Haike AntelmannIndex....................................................................................................................... 379