Frontiers in Clinical Drug Research: Anti-Cancer Agent

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Title
Copyright
End User License Agreement
Contents
Preface
List of Contributors
Essential Oils and Monoterpenes as Potential Anti-Cancer Agents
	Julia Pérez-Ramos1, Nimsi Campos-Xolalpa1, Roberto Serrano1, Cuauhtemoc Pérez1 and Salud Pérez1,*
	INTRODUCTION
	DISCUSSION
	CANCER CELL LINE
	ABBREVIATIONS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
A Glance at Drug Delivery Systems and Emerging Immunotherapeutic Strategies for the Treatment of Glioblastoma
	Greta Varchi1, Marzia Bruna Gariboldi2 and Claudia Ferroni2,*
	INTRODUCTION
	GLIOBLASTOMA STANDARD TREATMENT
	IMMUNOTHERAPY IN GBM
		Immunomodulator Therapy
		Passive Immunotherapy: Current State of Immune Checkpoint Inhibitors and Adoptive Therapy
			Immune Checkpoint Inhibitors (ICIs)
			Adoptive Cell Therapy
		Current Vaccine Trials in GBM
			Dendritic Cell Vaccine
			Peptide Vaccine
			Heat Shock Protein-based Vaccine
		Combination Strategies
			Checkpoint Inhibitors Combination Therapy
			Different Combination Strategies Targeting Other Immunotherapeutic Pathways
	DRUG DELIVERY-BASED APPROACH
		Pre-clinical Studies on Brain-targeted Nanocarriers
		Clinical Studies on Brain-targeted Nanocarriers
	CONCLUSION AND FUTURE ADVANCES
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
ctDNA in Solid Tumors: Role in Diagnosis, Prognosis and Treatment
	Sevgi Akaydin1,*, Ece Miser Salihoğlu1 and Dolunay Merve Fakioğlu1
	INTRODUCTION
	BREAST CANCER
		ctDNA as Diagnostic Biomarker of Breast Cancer
		ctDNA as Prognostic Biomarker of Breast Cancer
		ctDNA in the Targeted Therapy of Breast Cancer
	NON-SMALL CELL LUNG CANCER
		ctDNA as Diagnostic Biomarker of Non-Small Cell Lung Cancer
		ctDNA as Prognostic Biomarker of Non-Small Cell Lung Cancer
		ctDNA in the Targeted Therapy of Non-Small Cell Lung Cancer
	COLORECTAL CANCER
		Epigenetic Markers as a Diagnostic Biomarker in Colorectal Cancer
		ctDNA as a Diagnostic Biomarker in Colorectal Cancer
		ctDNA as Prognostic Biomarker in Colorectal Cancer
		Predictive ctDNA Markers in Colorectal Cancer
	PROSTATE CANCER
		ctDNA as Diagnostic Biomarker in Prostate Cancer
		ctDNA as Prognostic Biomarker in Prostate Cancer
		Predictive ctDNA Markers in Prostate Cancer
	OTHER TUMORS
		Gastrointestinal Stromal Tumors
		Head and Neck Cancer Squamous Cell Carcinoma
		Ovarian Cancer
	CONCLUSION
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Pitavastatin and Cancer: Current and Future Prospects
	Saeb Aliwaini1,*
	INTRODUCTION
	PITAVASTATIN: THE CHEMICAL COMPOUND
	ANTI-CANCER PROPERTIES OF PITAVASTATIN
		Antitumor Effects of Pitavastatin In Vitro
			Anti-proliferative Effect of Pitavastatin
			Induction of Cell Cycle Arrest
			Apoptosis Activation
			Activation of Autophagy
			Anti-migration Effect
			Anti-inflammatory Effect
		Antitumor Effects of Pitavastatin In Vivo
			Chemical Carcinogenesis Studies
			Tumor Xenograft Studies
	PITAVASTATIN TARGETS CELLULAR PATHWAYS
	LIMITATIONS
	CONCLUSION AND FUTURE PERSPECTIVE
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Cholesterol: A Potential Target for Intervention in Anti-Cancer Therapy
	Nimai Chand Chandra1,*, Amar Preet Kaur2,#, Ayantika Talukdar3,#, Nimisha Saxena4,# and Shrimanjunath Sankanagoudar5,#
	INTRODUCTION
	POLYCYCLIC HYDROCARBONS
		Potential Carcinogenic Effect
		Polycyclic Cholesterol: A Perspective on Cell Proliferation and Carcinogenicity
	TRANSMEMBRANE CHOLESTEROL TRANSPORTERS
		Plasma Membrane Transporter: LDLR
		Mitochondrial Membrane Transporter: StAR and PBR
		Nuclear Membrane Transporter: PBR
	INTER-CORRELATION BETWEEN CHOLESTEROL TRANSPORTERS AND CELL PROLIFERATION
	INTRACELLULAR CHOLESTEROL, CELL CYCLE ACTIVITY AND CELL PROLIFERATION
	CHOLESTEROL: A STEER TO CELL CYCLE ACTIVITY AND CELL PROLIFERATION
	CHOLESTEROL HOMEOSTASIS IN CANCER TUMOUR CELLS
		Cholesterol Homeostasis in Leukemia
		Cholesterol Homeostasis in Prostate Carcinoma
		Cholesterol Homeostasis in Breast Carcinoma
	REPROGRAMMED CHOLESTEROL METABOLISM IN CANCER CELLS
	IMMUNE CELL SUPPRESSION BY CARCINOGEN AND CARCINOMA
		Does Carcinogen Target Cholesterol to Abrogate Immune Cells?
		Effect of Carcinogen on T-Cell Immunity and the Role of Cholesterol
		Effect of Carcinogen on B-cell Immunity and the Role of Cholesterol
	BIPHASIC ROLE OF CHOLESTEROL IN PROMOTING TUMOR CELL PROLIFERATION AND TUMOR DEFENSIVE IMMUNE CELL DEATH
	ANTI-CANCER ANTI-CHOLESTEROL TARGET
	ANTI-CANCER DRUG TARGETS: PREVENTION AGAINST INIMICAL DOUBLE-EDGED REPROGRAMMED CHOLESTEROL HOMEOSTASIS
	SUMMARY AND CONCLUSION
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Subject Index
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