Epigenetics and Health: A Practical Guide

Cover
Title Page
Copyright Page
Contents
Preface
Overview
Chapter 1 How Do Genes Work?
	1.1 DNA, Genes and Proteins
	1.2 Gene Control, Homeostasis and Epigenetics
	1.3 DNA Methylation and Regulation of Gene Expression
	1.4 Post-transcriptional Regulation of Gene Expression
	1.5 Promoters and Enhancers
	1.6 Mutation Genotype, Phenotype, Epigenotype
	1.7 Conclusion
	Task
	Further Reading
Chapter 2 What is Epigenetics?
	2.1 Properties and Functions of Heterochromatin and Euchromatin
	2.2 DNA Methylation
	2.3 DNA Demethylation
	2.4 Chromatin Remodelling: Post-translational Modifications of Histone Proteins
	2.5 Non-coding RNAs
	2.6 Polycomb Proteins
	2.7 Conclusion
	Task
	Reference
	Further Reading
Chapter 3 Epigenetic Mechanisms, Homeostasis and Potential for Manipulating the Epigenome
	3.1 Pharmaceutical
	3.2 DNA Methylation and Impact on Nutrition
	3.3 Diet and Cancer Prevention
	3.4 Dietary DNMT Inhibitors
	3.5 Dietary HDAC Inhibitors
	3.6 Dietary Modulators of ncRNAs
	3.7 Precautions and Issues with Dietary Chemoprevention
	3.8 Epigenetics and Inflammation/Immune Response
	3.9 Epigenetic Inheritance Mechanisms
	3.10 X-inactivation
	3.11 Genomic Imprinting
	3.12 Transgenerational Epigenetic Inheritance
	3.13 Conclusion
	Task
	References
	Further Reading
Chapter 4 Tissues and Methods for Epigenetic Analyses
	4.1 Methods for Assessing Genome-Wide DNA Methylation-EPIGENOMICS
	4.2 Methods for Assessing Genome-Wide Histone Modifications
	4.3 Integrative Analysis – Looking at DNA Methylation and Histone Modification
	4.4 Novel Technologies
	4.5 Single-Cell Approaches
	4.6 ncRNAs
	4.7 Oxidised DNA Methylation
	4.8 Data Analysis
	4.9 Conclusion
	Task
	References
	Further Reading
Chapter 5 Normal and Abnormal Epigenetic Variation
	5.1 Epigenetics and Trained Immunity
	5.2 Epigenetics and Vascular Senescence
	5.3 Epigenetics and Obesity
	5.4 Epigenetics and Cumulative Toxin Exposure: Toxicoepigenomics
	5.5 Epigenetics, COVID-19 and Environmental Chemical Exposures
	5.6 Case Focus: Rheumatology
	5.7 Conclusion
	Task
	References
	Further Reading
Chapter 6 Cancer Epigenetics
	6.1 DNA Methylation and Role in Cancer Development
	6.2 Histone Modification and Role in Cancer Development
	6.3 Non-coding RNAs and Role in Cancer Development
	6.4 Chromatin Remodelling and Role in Cancer Development
	6.5 DNA Damage Response and Role in Cancer Development
	6.6 Epigenetics and Metabolic Programming in Cancer
	6.7 Summary
	6.8 Epigenetic Alterations in Cancer and Therapeutic Design
	6.9 Conclusion
	Task
	Further Reading
Chapter 7 Mental Health Epigenetics
	7.1 Specific Genes of Interest with Regards to Mental Health
		7.1.1 NR3C1– Glucocorticoid Nuclear Receptor Variant 1
		7.1.2 SLC6A4 – Serotonin Transporter
		7.1.3 BDNF – Brain-Derived Neurotrophic Factor
		7.1.4 OXTR – Oxytocin Receptor
	7.2 Specifically Focussing on Schizophrenia
	7.3 Transgenerational Epigenetic Influences on Predisposition to Psychiatric Disorders
	7.4 Suicide/PTSD
	7.5 Stress, Epigenetics and Transgenerational Epigenetic Inheritance: Consequences of Inequity/Deprivation
	7.6 Conclusion
	Task
	References
Chapter 8 Developing a Project
	8.1 Considerations for Epigenetic Research
		8.1.1 What Is Meaningful in Terms of Tissue Analysed?
		8.1.2 What Are the Health Promotion/Public Health Consequences?
		8.1.3 What Are the Consequences of Epigenetic Intervention?
		8.1.4 How Do We Design Epigenetic Drugs?
		8.1.5 What Does Predictive Epigenetic Testing Look Like?
	8.2 Conclusion
	8.3 Getting Started
	Why Do Epigenetic Research? What Do You Want to Achieve?
	Reference
	Further Reading
Index
EULA