Diversity of Selenium Functions in Health and Disease

Content: INTRODUCTIONWho Can Benefit from Selenium?Gerald F. Combs, JrSE COMPOUNDS AS A SOURCE FOR SELENOPROTEIN BIOSYNTHESISSelenium MetabolismYasumitsu OgraThe Molecular Regulation of Selenocysteine Incorporation into Proteins in EukaryotesAditi Dubey and Paul R. CopelandSelenocysteine tRNA[Ser]Sec: The Central Component of Selenoprotein BiosynthesisBradley A. Carlson, Ryuta Tobe, Petra A. Tsuji, Min- Hyuk Yoo, Lionel Feigenbaum, Lino Tessarollo, Byeong J. Lee, Ulrich Schweizer, Vadim N. Gladyshev, and Dolph L. HatfieldSE COMPOUNDS WITH SPECIFIC FUNCTIONSRedox Cycling and the Toxicity of Selenium Compounds: A Historical ViewJulian E. SpallholzSelenite in Cancer TherapySougat Misra, Marita Wallenberg, Ola Brodin, and Mikael BjornstedtForms of Selenium in Cancer PreventionKaram El-Bayoumy, Raghu Sinha, and John P. Richie, JrDUAL FUNCTIONS OF SELENOPROTEINS IN CANCERThioredoxin ReductaseBradley A. CarlsonGlutathione PeroxidaseAnna P. Kipp and Mike F. MullerThe 15-kDa Selenoprotein (Sep15)Petra A. Tsuji and Cindy D. DavisUNEXPECTED LINKSMultifaceted and Intriguing Effects of Selenium and Selenoproteins on Glucose Metabolism and DiabetesJi-Chang Zhou, Holger Steinbrenner, Margaret P. Rayman, and Xin Gen LeiSelenoproteins and the Metabolic SyndromeLucia A. Seale, Ann Marie Zavacki, and Marla J. BerryThioredoxin Reductase: A Coordinator in Metabolic ActivitiesSofi Eriksson and Edward E. SchmidtSelenium Mediates a Switch in Macrophage PolarizationK. Sandeep Prabhu, Avinash K. Kudva, and Shakira M. NelsonSELENOPROTEIN POLYMORPHISMS AND MUTATIONSGenetic Polymorphisms in Selenoprotein Genes: Functionality and Disease RiskCatherine Meplan, Janaina Lombello Santos Donadio, and John HeskethMutations in SECISBPErik Schoenmakers, Carla Moran, Nadia Schoenmakers, and Krishna Chatterjee