Computer Applications in Fermentation Technology: Modelling and Control of Biotechnological Processes

Front Matter....Pages i-xix
Introduction....Pages 1-2
Front Matter....Pages 3-3
Integrated Fermentor Sampling and Analysis....Pages 5-13
Measurement of Biological Reaction Rates Using Advanced pH Control Systems....Pages 15-22
Morphological Measurements on Filamentous Microorganisms by Image Analysis....Pages 23-35
Reconciliation of Measurement Data in Fermentation Using On-line Expert System....Pages 37-46
Glucose Biosensors for the Study and Control of Bakers Compressed Yeast Production....Pages 47-51
Computer Controlled System for On-line Monitoring of a Fermentation Process....Pages 53-57
Front Matter....Pages 59-59
Structured Modelling of Bioreactor Systems....Pages 61-67
Mathematical Simulation of Anaerobic Stratified Biofilm Processes....Pages 69-77
A New Approach for Development of Structured Growth Models....Pages 79-91
Modelling Secondary Metabolite production - Case Pleuromulin....Pages 93-103
Modelling of Kinetics, Mass Transfer and Mixing Phenomena in 45, 450 and 4500 L Tank Fermenters....Pages 105-109
A Software Tool for Fermentation Modelling....Pages 111-114
Hydrodynamic and Kinetic Modelling of a Flocculating Bioreactor with Cell Recycle....Pages 115-119
Modelling and Simulation of Naphthalene to Salicylic Acid Fermentation Process....Pages 121-125
Front Matter....Pages 127-127
An Introduction to System Identification, Parameter and State Estimation....Pages 129-158
Expert System Approach to Recognized the State of Fermentation and to Diagnose Faults in Bioreactors....Pages 159-168
Toward a Systematic Method for the Generalization of Fermentation Data....Pages 169-178
Adaptive Inferential Estimation and its Application to Biomass Control....Pages 179-186
Experimental Validation of a Methodology for On Line State Estimation in Bioreactors....Pages 187-194
Front Matter....Pages 127-127
Optimal Feeding Strategy for Identification of Monod-Type Models by Fed-Batch Experiments....Pages 195-204
Identification of a Simulated Continuous Yeast Fermentation....Pages 205-209
Structured Modeling and Parameter Identification of Budding Yeast Populations....Pages 211-216
Parameter Estimation of Kinetics and Modelling in Methanogenic Fermentation of Methanosarcina Barkeri ....Pages 217-220
On-Line Estimation of Cell Mass Using an Extended Kalman Filter....Pages 221-225
Observability by pH in Bioprocesses....Pages 227-231
Front Matter....Pages 233-233
Process Controlled Temperature Induction During Batch Fermentations for Recombinant DNA Products....Pages 235-251
Application of Expert System to the Operation and Control of Industrial Antibiotic Fermentation Process....Pages 253-261
IBE Fernentation Control....Pages 263-275
Improvement of the Penicillin Production in Bench-Scale Reactors by On-Line Measurement, Data Evaluation and Parameter-Adaptive Control....Pages 277-290
Online Parameter Identification and Computer Control of an Anaerobic Waste Water Treatment Process....Pages 291-295
On Experiences with Expert Systems in the Control of Bioreactors....Pages 297-302
Intelligent Purification of Monoclonal Antibodies....Pages 303-307
Front Matter....Pages 309-309
A Fed-Batch Process for Pullulanase Production....Pages 311-320
A New Approach for the Control of Baker’s Yeast Fed-Batch Fermentation....Pages 321-329
Lyapunov Design of Convergent Adaptive Controllers for a Class of Multilinear Systems Arising from Biotechnological Applications....Pages 331-339
A New Nonlinear Adaptive Approach to Automatic Control of Bioprocesses....Pages 341-348
Adaptive Algorithm for Estimation and Control of Fedbatch Bioprocesses....Pages 349-353
Nonlinear Estimation and Adaptive Control of a Fed-Batch Fermentor....Pages 355-359
Front Matter....Pages 361-365
Sensitivity Analysis in Static Optimization of Fermentation Plants....Pages 309-309
Maximum Production of Glutathione in Fed-batch Culture of Saccharomyces cerevisiae ....Pages 367-371
Front Matter....Pages 373-377
Management of Process Control Data For Bio-Process Analysis....Pages 379-379
Data Handling for Fermentation Development - An Industrial Approach....Pages 381-391
On-Line Monitoring of the Response of a Fermentation Process to Nutrient Additions....Pages 393-400
A Modelling Approach to Trouble Diagnosis by Multilevel Fuzzy Functions and its Application....Pages 401-410
Model Based Optimization of a SCP Fermentation Process....Pages 411-420
Adaptive Monitoring of Bioreactor Contamination....Pages 421-430
PC-Based On-Line Estimation of Derived Variables....Pages 431-435
The Use of Carbon Dioxide Evolution Rate in Consistency Checking Other Fermenter Sensor Outputs....Pages 437-441
Using the Downhill Simplex Method to Fit Complex Rate Equations to Data....Pages 443-447
Fermentation Fault Diagnosis Using Analytical Redundancy....Pages 449-453
Back Matter....Pages 455-459
....Pages 461-471