Complete accounts of integrated drug discovery and development : recent examples from the pharmaceutical industry

Content: ForewordPreface1. Discovery and Development of GDC-0994: A Selective and Efficacious Small Molecule Inhibitor of ERK1/22. Preclinical Identification and Development of AM-6138: An Inhibitor of BACE1 for the Treatment of Alzheimer's Disease3. Discovery and Chemical Development of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer's Disease4. Discovery and Chemical Development of JNJ-50138803, a Clinical Candidate BACE1 Inhibitor5. Discovery and Development of Ruzasvir: An Investigational Next Generation Pan-Genotype HCV Nonstructural Protein 5A (NS5A) Inhibitor for the Cure of Hepatitis C Virus Infections6. AZD6564, Discovery of a Potent 5-Substituted Isoxazol-3-ol Fibrinolysis Inhibitor and Development of an Enantioselective Large-Scale Route for Its Preparation7. Design and Development of the Glucokinase Activator AZD16568. Development of a Reversible P2Y12R Antagonist, AZD1283-Discovery Research and Large-Scale Chemistry9. Discovery, Process Development, and Scale-Up of a Benzoxazepine-Containing mTor InhibitorEditors' BiographiesAuthor IndexSubject Index