Clinical Management of Melanoma

Front Matter....Pages I-XXXIV
The Significance of Metastases to the Surgeon....Pages 1-2
The Spread of Rectal Cancer into Veins and the Mechanism of Distant Embolism....Pages 3-8
Squamous Carcinomas of the Head and Neck: Patterns and Mechanisms of Local Invasion and Metastasis....Pages 9-12
The Relationship Between Malignant Melanoma Morphology, Metastases and Patient Survival....Pages 13-17
Animal Tumour Models: The Intrusion of Artefacts....Pages 18-22
Models of Prostate, Breast, Lung, and Intestinal Carcinomas Which Metastasize in Rats....Pages 23-27
A New In-Vitro Model to Study Tumour Cell Invasion....Pages 28-32
Invasiveness and the ‘Metastatic Potential’ of Tumour Cells....Pages 33-37
A Possibility of Predicting the Metastatic Potential of Tumours by Implantation into Chick Embryo Blastoderms....Pages 38-44
An Experimental Study on the Barrier Function of Lymph Nodes to Tumor Cells....Pages 45-49
Metastases from DMBA-Induced Carcinomas in Hamster Cheek Pouch....Pages 50-54
Quantitation and Cellular Growth of Occult Metastases of a Rat Mammary Carcinoma....Pages 55-59
Comparison of Natural and Artificial Lung Metastases from a Murine Tumour of Spontaneous Origin....Pages 60-64
Growth Inhibition of Simulated Metastases by a Large Primary Tumor....Pages 65-68
Quantitative Studies on Metastasis Using Yoshida Rat Ascites Hepatomas, with Special Reference to the Biological Characteristics in Metastasizability and Drug Sensitivity....Pages 69-74
Canine Osteosarcoma and Canine Mammary Carcinoma....Pages 75-79
Selection of a Human Malignant Melanoma X Hamster Hybrid Cell Line by Metastasis....Pages 80-84
Morphological Aspects of the Interaction of Blood Coagulation and Tumour Dissemination....Pages 85-89
Cancer Cell Procoagulant Activity, Warfarin and Experimental Metastases....Pages 90-94
Molecular Mechanism of Fibrinolysis and Its Potential Role in Metastasis....Pages 95-99
Fibrinolysis and Anticoagulation in Colo-Rectal Cancer — The Way Ahead....Pages 100-104
Studies on Factors Influencing the Lodgement of Circulating Tumour Cells....Pages 105-108
Critical Analysis of Experimental Models for the Antimetastatic Effects of Anticoagulants....Pages 109-115
Effect of Fibrinolysis Inhibition on the Growth and Hematogenous Dissemination of Cancer....Pages 116-121
Mechanisms Behind the Inhibiting Effect of Tranexamic Acid on Tumour Growth and Spread....Pages 122-126
The Inhibitory Effect of Sulfated Polysaccharides, Ancrod or Tranexamic Acid on Pulmonary Metastases in Animals....Pages 127-131
Prostacyclin as a Marker for Diagnosing and Staging Carcinoma of the Prostate....Pages 132-135
Prostaglandins and Metastasis....Pages 136-141
The Application of a Defibrinogenating Snake Venom Enzyme in Experimental Tumor Metastasis....Pages 142-146
Effect of Ticlopidine on Blood-Borne Metastasis....Pages 147-152
Failure of RA233 to Affect the Growth of Intravenously Injected Murine Lymphoma Cells....Pages 153-158
Failure of Flurbiprofen to Affect the Metastasis of Rodent Sarcomas....Pages 159-162
In Vivo and in Vitro Selection of Experimental Metastatic Variants of Rodent Melanoma, Mammary Carcinoma and Lymphosarcoma....Pages 163-168
The Role of Tumor Cell-Basement Membrane Interactions in the Metastatic Process....Pages 169-173
Morphological and Biochemical Differences of Primary and Metastatic Human Melanoma Cells....Pages 174-178
Lewis Lung Carcinoma: Selecting Metastatic Variants....Pages 179-183
Malignant Properties of Clones Isolated from a Mouse Fibrosarcoma....Pages 184-188
Characteristics of Tumor Cell Clones with Varying Malignant Potential....Pages 189-193
Invasion of Lung and Liver Tissue by Different Types of Tumour Cells....Pages 194-200
Interactions of Tumor Cells with Isolated Hepatocytes. A Model for the Infiltration of Blood-Borne Tumor Cells in the Liver....Pages 200-203
Ultrastructural Features of Intravascular and Extravascular Migration of Cancer Cells....Pages 204-209
Characteristics of Metastasizing and Non-Metastasizing Tumors and Their Interaction with the Host Immune System in the Development of Metastasis....Pages 210-214
Metastatic Potential of Tumor Cells from Spontaneous Metastasis....Pages 215-221
Cell Surface Changes Associated with the Selection of Spontaneous Metastases....Pages 222-226
Intrinsic and Extrinsic Factors Governing the Expression of Metastatic Potential....Pages 227-231
Metastatic Potential of SK-Br-3 Cells Treated with L-Cysteine or Ascorbic Acid....Pages 232-236
Effect of Pre-Treatment with Antisera Against Choriogonadotropin on the Metastatic Potential of a Rat Adenocarcinoma....Pages 237-241
Metastases of Mammary Tumours in BR6 Mice....Pages 242-245
Fixation of α -Melanocyte Stimulating Hormone ( α -MSH) to Human Metastatic Melanoma Cells in Vitro and in Vivo....Pages 246-251
Metastases of Human Tumours in the Nude Mouse: The Behaviour of Colon Carcinoma Xenografts....Pages 252-259
Immune Regression of Metastases Following Hyperthermic Treatment of Primary Tumours....Pages 260-265
Clonal Tumor Cell Variants Arising by Adaptation....Pages 266-271
Reversibility of Immunological and Antitumoral Effects Produced in Vivo by Particulate β1–3 Glucans....Pages 272-277
Modulation of Tumor Growth and Metastasis by an Acute Inflammation....Pages 278-283
Enhancement of Pulmonary Metastases Induced in Mice by Cyclophosphamide: Role of the Immune System....Pages 284-288
Antimetastatic Effects of Intrapleurally Injected Corynebacterium Parvum....Pages 289-293
Does C. Parvum Treatment Affect Tumour Blood Flow and Hence Metastasis?....Pages 294-298
Reticuloendothelial System Function in Cancer Patients Treated with C. Parvum....Pages 299-303
Inhibition of Pulmonary Metastasis of Lewis Lung Tumor by Nocardia Rubra-Cell Wall Skeleton or Schizophyllan....Pages 304-309
Minimal Residual Disease May be Treated by Chessboard Vaccination with Vibrio Cholerae Neuraminidase (VCN) and Tumor Cellss....Pages 310-314
Application of the Leukocyte Migration Test (LMT) to Patients with Metastases: Evidence in Favour of a Change in Host Response....Pages 315-319
Computed Tomography in the Staging of Malignancy....Pages 320-325
Serial Quantitative Skeletal Scintigraphy in Breast Cancer....Pages 326-330
Further Studies on the Effect of Prostaglandin Synthesis Inhibitors and Diphosphonates on Tumour-Mediated Osteolysis....Pages 331-335
Potential Clinical use of Diphosphonates Against Bone Metastases and Hypercalcaemia of Malignancy....Pages 336-340
Multiparametric Biochemical Study in the Diagnosis of Bone Metastasis of Breast Cancer....Pages 341-345
Acute Changes in Calcitonin Levels in Lung Cancer Patients Treated with C. Parvum: Do These Reflect in Vivo Killing of Tumour Cells?....Pages 346-350
Serial Quantitative Bone Scanning of Metastatic Tumour in Rats....Pages 351-355
Experimental Study on Characteristics of Microcirculation in Tumor Tissue, with Reference to Cancer Chemotherapy....Pages 356-360
Development of Severe Radiation Pheumonitis in Patients with Oat Cell Carcinoma During Combined Modality Therapy....Pages 361-367
Effect of Hemithorax Irradiation of Young Mice on Pulmonary Metastatic Deposits from Subsequently Developing Spontaneous Mammary Tumours....Pages 368-368
The Chemotherapy of Micrometastases — An Overview of Current Status....Pages 369-374
Adjuvant Razoxane in Resectable Colorectal Cancer....Pages 375-380
Changing Aspects in the Surgical Approach to Metastatic Disease; Influence of Chemotherapy on Indications for and Results of Metastasectomies....Pages 381-387
Clinical Study on Selective Enhancement of Drug Delivery by Angiotensin II in Cancer Chemotherapy....Pages 388-394
Differences and Similarities in Adjuvant Chemotherapy in Mouse and Man....Pages 395-395
Drug Response of Two Different in Vitro Tumour Lines Derived from Lung Metastases of 3LL....Pages 396-400
Therapeutic Implications of Heterogeneous Tumor Cell Populations....Pages 401-405
Effect of Bleomycin Scheduling on Lung Metastases of 3LL and a Subline of Different Metastatic Potential....Pages 406-410
Metastasis of Lewis Lung Carcinoma (LL) Regrowing after Cytotoxic Treatments....Pages 411-415
Adjuvant Chemotherapy Following Surgery for Small-Cell Carcinoma of the Lung....Pages 416-421
Cell Surface Sialylation of Metastatic Variant Murine Tumor Cell Lines....Pages 422-426
Potential for Selective Inhibition of Metastasis....Pages 427-431
Tumour Load Dependent Effectiveness of Cyclophosphamide in Lewis Lung Carcinoma....Pages 432-435
Prophylactic Antimetastatic Agents: Dimethyltriazenes, N-Diazoacetylglicine Derivatives and other Neutral Proteinase Inhibitors....Pages 436-440
Selective Chemotherapy of Metastasis By Drug Carrying Fat Emulsion or Tumor Specific Antibody....Pages 441-445
Treatment of Metastases in Long Bones....Pages 446-449
Immunotherapy as Adjuvant Treatment for Residual Tumors....Pages 450-450
Back Matter....Pages 451-456