Clinical Aspects of Neutron Capture Therapy

Front Matter....Pages i-xiii
Dose Rate and Therapeutic Gain....Pages 1-7
Swine Skin: A Model to Evaluate Dose Recovery from Different Radiations....Pages 9-20
Neutron Capture Therapy in Support of Other Radiation Treatment....Pages 21-26
Research on Neutron Capture Therapy in the USSR....Pages 27-38
BNCT Project in Czechoslovakia....Pages 39-48
Proposed Clinical Trial Studying the Pharmacokinetics of B.S.H.....Pages 49-51
Fractionation in Boron Neutron Capture Therapy....Pages 53-61
Dose Fractionation in Neutron Capture Therapy for Malignant Melanoma....Pages 63-67
Thermal Neutron Capture Therapy: The Japanese-Australian Clinical Trial for Malignant Melanoma....Pages 69-73
BNCT and Dose Fractionation....Pages 75-79
Some Thoughts on Tolerance, Dose, and Fractionation in Boron Neutron Capture Therapy....Pages 81-85
Delayed Effects of Neutron Irradiation on Central Nervous System Microvasculature in the Rat....Pages 87-93
Pre-Clinical Studies on Boron Neutron Capture Therapy....Pages 95-105
Boron Compounds for Neutron Capture Therapy....Pages 107-111
Fractionation Considerations for Boron Neutron Capture Therapy: The Perspective of a Clinician....Pages 113-114
Vascular Factors Affecting Drug Delivery to Brain Tumors....Pages 115-120
Clinical Considerations in the Use of Thermal and Epithermal Neutron Beams for Neutron Capture Therapy....Pages 121-134
A Proposed Protocol for Clinical Trials of Boron Neutron Capture Therapy in Glioblastoma Multiforme....Pages 135-144
The Effect of Ionizing Radiation on the Blood-Brain-Barrier (BBB): Considerations for the Application of Boron Neutron Capture Therapy (BNCT) of Brain Tumors....Pages 145-152
Computerized Axial Tomographic and Magnetic Resonance Imaging Scan Follow-up of Two Patients after Boron Neutron Capture Therapy for Glioblastoma Multiforme....Pages 153-163
A Stochastic Model for High-Let Response for Boron Neutron Capture Therapy (BNCT)....Pages 165-178
Distributions of Sulfhydryl Borane Monomer and Dimer in Rodents and Monomer in Humans: Boron Neutron Capture Therapy of Melanoma and Glioma in Boronated Rodents....Pages 179-191
A Carboranyl Porphyrin for Boron Neutron Capture Therapy of Brain Tumors....Pages 193-203
Distribution of a Boronated Porphyrin in Murine Tumors....Pages 205-212
Survival Assays with a Boronated Porphyrin as Measured with Hamster V-79 Cells in Culture....Pages 213-218
Neutron Capture Therapy for Melanoma....Pages 219-232
Tumor-Seeking Compounds for Boron Neutron Capture Therapy: Synthesis and Biodistribution....Pages 233-241
Boron-11 Magnetic Resonance Imaging and Spectroscopy; Tools for Investigating Pharmacokinetics for Boron Neutron Capture Therapy....Pages 243-249
Selective Thermal Neutron Capture Therapy and Diagnosis of Malignant Melanoma: From Basic Studies to First Clinical Treatment....Pages 251-260
Workshop Summary of Moderators’ Reports....Pages 261-262
Moderators’ Report and Discussions....Pages 263-276
Working Group on Optimization of Radiation Dose Delivery....Pages 277-297
Blood-Brain-Barrier Impairment after Irradiation: Implication in Boron Neutron Capture Therapy....Pages 299-309
Implications of Genotypic and Microenvironmental Heterogeneity for the Cure of Solid Tumors by Neutron Capture Therapy....Pages 311-317
Status Report on the Development of a Spallation Neutron Source for Neutron Capture Therapy (NCT)....Pages 319-323
Uptake of Boron into Human Gliomas of Athymic Mice and into Syngeneic Cerebral Gliomas of Rats after Intracarotid Infusion of Sulfhydryl Boranes....Pages 325-332
Toxicities of Na 2 B 12 H 11 SH and Na 4 B 24 H 22 S 2 in Mice....Pages 333-351
Back Matter....Pages 353-370