Chromosomal Aberrations: Basic and Applied Aspects

Front Matter....Pages I-XIII
Quantitative Detection of Chromosome Structures by Computerized Microphotometric Scanning....Pages 1-12
Heterogeneity of DNA Repair in Relation to Chromatin Structure....Pages 13-21
The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?....Pages 22-30
DNA Lesions, DNA Repair, and Chromosomal Aberrations....Pages 31-40
Is It Misrepair or Lack of Repair Which Kills Cells Irradiated in G 2 ?....Pages 41-49
Inhibitors of DNA Topoisomerases and Chromosome Aberrations....Pages 50-60
Restriction Endonuclease- and Radiation-Induced DNA Double-Strand Breaks and Chromosomal Aberrations: Similarities and Differences....Pages 61-69
The Use of Restriction Endonucleases to Study the Mechanisms of Chromosome Damage....Pages 70-78
Induction of Chromosomal Aberrations by the Restriction Endonuclease AluI in Chinese Hamster Ovary (CHO) Cells: Influence of Glycerol on Aberration Frequencies....Pages 79-85
Patterns of Chromosome Variation in Neoplasia....Pages 86-100
Tumorigenesis and Tumor Response: View from the (Prematurely Condensed) Chromosome....Pages 101-112
Detection of Cancer-Prone Individuals Using Cytogenetic Response to X-Rays....Pages 113-120
Human Disorders with Increased Spontaneous and Induced Chromosomal Instability....Pages 121-129
Possible Causes of Variability of the Adaptive Response in Human Lymphocytes....Pages 130-139
Adaptation of Human Lymphocytes to Radiation or Chemical Mutagens: Differences in Cytogenetic Repair....Pages 140-150
Radio-Adaptive Response: A Novel Chromosomal Response in Chinese Hamster Cells in Vitro....Pages 151-162
On Adaptive Responses of Plant Meristem Cells in Vivo - Protection Against Induction of Chromatid Aberrations....Pages 163-179
Chromosome Aberrations in A-Bomb Survivors, Hiroshima and Nagasaki....Pages 180-190
Biological Dosimetry of Absorbed Radiation Dose: Considerations of Low-Level Radiations....Pages 191-201
Use of Micronuclei in Biological Dosimetry of Absorbed Radiation Dose....Pages 202-211
Biological Dosimetry After Radiation Accidents....Pages 212-223
Dose Estimates and the Fate of Chromosomal Aberrations in Cesium-137 Exposed Individuals in the Goiania Radiation Accident....Pages 224-230
Cytogenetic Studies in Male Germ Cells, Their Relevance for the Prediction of Heritable Effects and Their Role in Screening Protocols....Pages 231-241
Use of in Vivo Micronucleus Tests with Mammalian Cells for Clastogenicity and Carcinogenicity Studies....Pages 242-259
In Vitro Chromosomal Aberration Test — Current Status....Pages 260-272
Clastogenesis in Vitro Under Extreme Culture Conditions....Pages 273-286
Life-Style and Genetic Factors that Determine the Susceptibility to the Production of Chromosome Damage....Pages 287-301
Back Matter....Pages 303-319